Pathology of Synovial Lipomatosis and its Clinical Significance

Rao, Shalinee; Rajkumar, Aarthi; Elizabeth, Mintu Joyce; GANESAN, VAISHNAVI; Kuruvilla, Sarah

doi:10.4103/0974-2727.86839

Cited by 23 publications

(69 citation statements)

References 13 publications

(18 reference statements)

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“…Rao et al reported that among the eight patients studied in their series, four had high BMI and one had low BMI. 23 The mean BMI was 28.3 AE 3.38 in our study. None of the patients was underweight.…”

Section: Discussionsupporting

confidence: 41%

Results of Arthroscopic Synovectomy for Treatment of Synovial Lipomatosis (Lipoma Arborescens) of the Knee

Malkoç

Korkmaz

2017

J Knee Surg

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Synovial lipomatosis (SL; lipoma arborescens) is a tumor-like condition with villous proliferation of the synovium. The exact etiology of SL is still unknown. The knee is the most commonly involved part. The goal of this retrospective study was to report the results of arthroscopic synovectomy in patients with SL in their knee joints as well as to emphasize the importance of considering this pathology when treating patients with recurrent knee joint effusions. In total, 21 patients (8 females and 13 males) were evaluated retrospectively from May 2009 to July 2014. The mean follow-up period was 29.13 (range, 12-61) months. The mean duration of compliance was 22.76 (range, 7-61) months. All patients were evaluated by Knee Society score pre- and postoperatively. The mean preoperative and last follow-up Knee Society scores were 67.82 and 88.23 points, respectively. There was a significant difference between the preoperative and postoperative Knee Society scores ( = 0.0001). Histopathological examinations showed that the subsynovial layer exhibited diffuse replacement by mature fat cells that had formed villous projections. In addition, infiltration of mononuclear inflammatory cells was observed at different stages. SL is a nondestructive and benign tumor pathology of the knee joint without a clearly identified etiology. The main difficulty in diagnosis is lack of clinical practice.

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Section: Discussionsupporting

confidence: 41%

Results of Arthroscopic Synovectomy for Treatment of Synovial Lipomatosis (Lipoma Arborescens) of the Knee

Malkoç

Korkmaz

2017

J Knee Surg

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“…The histomorphology of synovial lipomatosis is associated with adipocyte metaplasia and inflammation, and fibrosis (16); thus, synovial lipomatosis can be more accurately described as the process of overgrowth and infiltration of mature adipose tissue within the synovium. Occasionally, fibrous septa may be visible between the vascular channels and adipose tissue within the lesion (17).…”

Section: Discussionmentioning

confidence: 99%

Synovial lipomatosis of the metatarsophalangeal joint: A case report

et al. 2016

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Abstract. Synovial lipomatosis, also termed lipoma arborescens, is an extremely rare disorder of the synovium that causes joint pain, swelling and effusion. To date, only a small number of cases have been reported in the literature. The current study presents the case of a 44-year-old male with repeated swelling of the metatarsophalangeal joints of the left hallux, which had persisted for ~3 years. The main clinical manifestations on presentation included multiple osseous lumps and limited activity of the left hallux without pain. Magnetic resonance imaging of the left hallux revealed a mass surrounding the left metatarsophalangeal joints. Subsequently, the lesion was resected. Pathological examination revealed well-defined lobules of mature adipocytes separated by thin fibrous septa, which indicated a diagnosis of synovial lipomatosis of the metatarsophalangeal joint of the left foot. The aim of this study was to evaluate synovial lipomatosis of the metatarsophalangeal joint, with an analysis of the clinical parameters and pathological features of the disorder.

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“…11 Al ismail et al 12 and Hubscher et al 13 had also proposed inflammation and mechanical factors in etiopathogenesis of osteoarthritis secondary to lipoma arborescens. Rao et al 14 had proposed that LA could result from inappropriate fat deposition and degenerative disease of the joints. Moreover, the cases described in literature were of older age group in which the osteoarthritis is as such common.…”

Section: Discussionmentioning

confidence: 99%