Pathology of sub-chronic cadmium and chlorpyrifos toxicity in broilers

Singh, Rajendra K.; Srivastava, Arun; Gangwar, Neeraj Kumar; Giri, Devesh Kumar; Singh, R. A.; Kumar, Rahul

doi:10.5958/0973-970x.2016.00076.6

Cited by 8 publications

(11 citation statements)

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“…The increased levels could be due to severe degeneration and necrosis of hepatocytes that result in release of transaminases in the blood. These findings can be correlated with the histological changes in the present study and are in agreement with the reports of Prabu et al (2012) and Singh et al (2016).…”

Section: Histopathological Findings In Liversupporting

confidence: 94%

“…The histopathological changes are further corroborated by the decreased levels of GSH and SOD in rats exposed to CPF that might have caused membrane damage of cells resulting into degenerative to necrotic changes in liver. Similar changes were also reported by Savithri et al (2010) and Singh et al (2016). Irregular hepatic cords were observed.…”

Section: Histopathological Findings In Liversupporting

confidence: 91%

“…Irregular hepatic cords were observed. Similar observations were also noticed by Singh et al (2016) and might be due to synergistic action of CdCl 2 and CPF.…”

Section: Histopathological Findings In Liversupporting

confidence: 85%

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Changes in Biochemical Parameters, Antioxidative Enzymes and Histopathology of Liver Induced by Cadmium (Cd) and Chlorpyrifos (CPF) in Wistar Rats

Ravikumar

Madhuri

Lakshman

et al. 2021

IJAR

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Background: Cd and CPF intoxication may occur directly through drinking water. Since the population tend to receive combination of multiple intoxicants through environment contamination, there is need for conducting studies to assess the impact of individual and combined environmental pollutants. The present research work was designed to study hepatotoxicity induced by Cd, CPF and their combination.Methods: The experiment was carried out for 28 days in Wistar rats. G1: Control. G-2:CdCl2 @ 22.5mg/ kg b.wt / oral. G3: CPF @ 25 mg/ kg b.wt /per oral. G4:CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Biochemical parameters ware estimated from serum and liver samples were processed for tissue antioxidative parameters and histopathological examination. Result: Higher mean values of AST, ALT, ALP and lower liver GSH and SOD were observed in G2, 3 and 4 on 15th and 29th day when compared with G1. Liver in G2 and 3 showed mild degenerative changes, areas of necrosis and loss of architecture. In G4, lesions were moderate in severity. In addition, moderate perivascular fibrosis of portal triad was observed. The effects in combined group were severe than individual groups due to synergistic action of the combined pollutants.

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Section: Histopathological Findings In Liversupporting

confidence: 94%

Section: Histopathological Findings In Liversupporting

confidence: 91%

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Changes in Biochemical Parameters, Antioxidative Enzymes and Histopathology of Liver Induced by Cadmium (Cd) and Chlorpyrifos (CPF) in Wistar Rats

Ravikumar

Madhuri

Lakshman

et al. 2021

IJAR

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“…The observed clinical signs of chickens treated with cadmium showed feed refusal, loss of appetite, dullness, restlessness, depression, gasping, difficult breathing, ruffled feather, inability to stand and move, weakness, recumbancy, imbalance gait which may progress to lameness and diarrhea. In some cases which may be due to Cd toxic immunosuppressive effect, increased the susceptibility of the birds to stress and disease was observed [32,33]. Mortality rate of groups 2, 3, 4 and 5 were 32, 20, 15 and 5%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding to proteinogram of birds exposed to cadmium toxicity in the 2 nd Group, a significant decrease in the values of serum total proteins, albumin and globulins was observed. It could be attributed to hepatic and renal tubular dysfunction, change in protein synthesis and/or metabolism or decrease in feed consumption [33,[43][44][45][46]. Meanwhile, the protective mechanism of Se, vitamin E and/or both in supplemented chickens may be attributed to their ability to scavenge ROS and enhancement of antioxidant system in Cd induced tissue damage as the interactions between Se and high level of Cd resulted in partial amelioration of Cd toxicity in different system [42].…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Studies on the Ameliorative Effects of Selenium and Vitamin E against Cadmium Toxicity in Chickens

Hashem

El-Dein

ELgelil

2019

Zagazig Veterinary Journal

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Cadmium (Cd) is one of the most dangerous environmental bioaccumulative heavy metals that concern a vital interest due to its injurious to animal and public health. An experimental trial was conducted for six weeks to evaluate the protective effect of selenium and /or vitamin E against the adverse effect of cadmium. One hundred and five, one day old broiler chicks were divided into five random groups. Group1 (negative control) was fed on basal diet; Group 2 was supplemented with 100 mg of cadmium /kg diet; Group 3 was supplied with 0.5 mg/kg diet of selenium; Group 4 was fed on 100 mg/kg diet of vitamin E and Group 5 was supplemented with Cd, Se and vitamin E combinations. The results revealed that cadmium group showed a highly significant increase in serum alanine amino transferase (ALT) and aspartate amino transferase (AST) (36±1.1and 220±3.53, respectively) activities, serum uric acid and creatinine (25.68±1.01 and 4.38±0.15, respectively) and a significant decrease in serum total proteins, albumin and globulins values (2.34±0.09, 1.14±0.05 and1.20±0.05, respectively) particularly at the end of the sixth week in comparable to the control group. In addition, a significant increase in serum malondialdehyde (MDA) and nitric oxide (NO) (3.9±0.09 and 51.33±0.88, respectively), a significant decrease in glutathione peroxidase (GSH-PX) values (0.05±0.005) associated with a significant reduction in interleukin 2 (IL2) and interleukin 10 (IL10) (1.8±0.30 and 7.4±0.43, respectively) values were reported specially at the end of the sixth week compared with the control group. Overall, our results showed an improvement in groups supplied with either Se or vitamin E when compared with cadmium group. In conclusion, supplementation of selenium or vitamin E alone didn't recover the depressive effect of Cd but their combination could improve its deleterious effect due to their antioxidant activity.

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Tissue Bioaccumulation and Toxicopathological Effects of Cadmium and Its Dietary Amelioration in Poultry—a Review

Kar

Patra

2021

Biol Trace Elem Res

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Pathology of sub-chronic cadmium and chlorpyrifos toxicity in broilers

Cited by 8 publications

References 0 publications

Changes in Biochemical Parameters, Antioxidative Enzymes and Histopathology of Liver Induced by Cadmium (Cd) and Chlorpyrifos (CPF) in Wistar Rats

Changes in Biochemical Parameters, Antioxidative Enzymes and Histopathology of Liver Induced by Cadmium (Cd) and Chlorpyrifos (CPF) in Wistar Rats

Clinicopathological Studies on the Ameliorative Effects of Selenium and Vitamin E against Cadmium Toxicity in Chickens

Tissue Bioaccumulation and Toxicopathological Effects of Cadmium and Its Dietary Amelioration in Poultry—a Review

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