Tissue Bioaccumulation and Toxicopathological Effects of Cadmium and Its Dietary Amelioration in Poultry—a Review

Kar, Indrajit; Patra, Amlan Kumar

doi:10.1007/s12011-020-02503-2

Cited by 44 publications

(34 citation statements)

References 124 publications

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“…The main harm of cadmium to the human body is kidney damage. Nearly 50% of the cadmium is accumulated in the kidney, especially in the proximal convoluted tubule, leading to kidney damage and chronic kidney disease [5][6][7][8]. Previous studies revealed that up to 7% of the global population suffers from chronic kidney disease caused by cadmium [9].…”

Section: Introductionmentioning

confidence: 99%

Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities

et al. 2021

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Kidney damages caused by cadmium are considered to be one of the most dangerous consequences for the human body. This study aimed to investigate the protective effects of fucoxanthin supplementation on mice models subjected to cadmium-induced kidney damage. The mice treated with cadmium chloride (CdCl 2 ) were observed to have significantly reduced the crosssection area of glomeruli. Cadmium exposure has also caused the damage of the structural integrity of mitochondria and increased blood urea nitrogen (BUN), kidney injury molecule 1 (KIM1), and neutrophil gelatinase associated lipocalin (NGAL) levels. Peroxidase (POD), superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) levels in cadmium-exposed mice were markedly declined. Caspase3, caspase8, and caspase9 gene expressions in association with apoptosis were dramatically elevated in renal tissues. The CdCl 2 treated mice were orally administered with 50 mg/kg Shenfukang, 10 mg/kg, 25 mg/kg, and 50 mg/kg fucoxanthin for 14 days. The results revealed that high doses of fucoxanthin administration significantly decreased BUN, KIM1, NGAL levels, increasing POD, SOD, CAT, and ascorbate APX levels. Fucoxanthin administration also promoted recovery of the renal functions, micro-structural organization, and ultrastructural organization in the renal cells. In summary, the ameliorative effects of fucoxanthin supplementation against cadmium-induced kidney damage were mediated via inhibiting oxidative stress and apoptosis, promoting the recovery of structural integrity of mitochondria.

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Section: Introductionmentioning

confidence: 99%

Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities

et al. 2021

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“…Czech Journal of Animal Science, 66, 2021 (09): 339-348 https://doi.org/10.17221/86/2021-CJAS 2005) and transferred from soil to plant with relatively high bioavailability (Lu et al 2017;Zhu et al 2018). Therefore, from these natural and anthropogenic sources, once released into the environment, Cd can easily move to water and soil and accumulate in crops and enter the food chain, adversely affecting poultry health (Kar and Patra 2021).…”

Section: Reviewmentioning

confidence: 99%

“…A recently published review by Olgun et al (2020) indicated that 10-20 mg of Cd/kg of feed is sufficient to observe toxicity symptoms. These contrast reports estimating the toxic level of Cd might be reasoned by concentrations in feeds, different species of the birds, sex, age, systems of bird rearing and the duration of intake (Olgun et al 2020;Kar and Patra 2021). Additionally, an interaction between Cd and some dietary elements like zinc and copper could be the main reason for a non-precise estimation of minimum and maximum levels of Cd for safe dietary concentrations.…”

Section: Toxic Levels Of Cadmiummentioning

confidence: 99%

“…Liver is the first targeted organ by Cd after absorption from gastrointestinal tracts (DelRaso et al 2003;Rani et al 2014). Whereas the kidneys are the second most affected organs by Cd toxicity as they function for excretion of toxic compounds (Kar and Patra 2021). In broiler chickens, Cinar et al (2011) reported severe hydropic degeneration in liver tissues with Cd administration (60 mg of Cd/kg of feed) for 42 days.…”

Section: Adverse Effects Of CD On Poultry Performancementioning

confidence: 99%

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2022

Czech J. Anim. Sci.

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Cadmium (Cd) is a toxic heavy metal, discharged into environments naturally or anthropogenically, where industrial and agricultural revolutions have led to serious Cd pollution into the environment. Poultry feed may be contaminated by Cd due to its presence in concentrates and supplements, and also in the machinery and equipment used in the feed production and processing. After absorption in the digestive system, Cd largely accumulates in kidneys, liver, bones and other organs and causes irreversible damage to these organs. Higher doses of Cd in poultry diet reduced feed intake, body weight, bone mineral density, egg production and eggshell quality. Selenium (Se) is an essential micronutrient and important component of a variety of antioxidant enzymes, with the ability to antagonize metal toxicity including Cd. Hence, in the current review, we try to summarize recent information about the toxicological effects of Cd and provide updated information about the role of Se as an effective strategy in reducing Cd toxicity in poultry.

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“…Czech Journal of Animal Science https://doi.org/10.17221/86/2021-CJAS 2005) and transferred from soil to plant with relatively high bioavailability (Lu et al 2017;Zhu et al 2018). Therefore, from these natural and anthropogenic sources, once released into the environment, Cd can easily move to water and soil and accumulate in crops and enter the food chain, adversely affecting poultry health (Kar and Patra 2021).…”

Section: Reviewmentioning

confidence: 99%

Adverse effects of cadmium on poultry and role of selenium against it: An updated review

Ketta¹,

Tůmová²,

Stupka³

et al. 2021

CZECH J ANIM SCI

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Cadmium (Cd) is a toxic heavy metal, discharged into environments naturally or anthropogenically, where industrial and agricultural revolutions have led to serious Cd pollution into the environment. Poultry feed may be contaminated by Cd due to its presence in concentrates and supplements, and also in the machinery and equipment used in feed production and processing. After absorption in the digestive system, Cd largely accumulates in kidneys, liver, bones and other organs and causes irreversible damage to these organs. Higher doses of Cd in the poultry diet reduced feed intake, body weight, bone mineral density, egg production and eggshell quality. Selenium (Se) is an essential micronutrient and important component of a variety of antioxidant enzymes, with the ability to antagonize metal toxicity including Cd. Hence, in the current review, we try to summarize recent information about the toxicological effects of Cd and provide updated information about the role of Se as an effective strategy in reducing Cd toxicity in poultry.

show abstract

Tissue Bioaccumulation and Toxicopathological Effects of Cadmium and Its Dietary Amelioration in Poultry—a Review

Cited by 44 publications

References 124 publications

Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities

Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities

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Adverse effects of cadmium on poultry and role of selenium against it: An updated review

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