Pathologic changes in muscle in primary fibromyalgia syndrome

Yunus, Muhammad B.; Kalyan‐Raman, Uma P.; Kalyan-Raman, Krishna; Masi, Alfonse T.

doi:10.1016/0002-9343(86)90872-7

Cited by 71 publications

(31 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Muscle biopsies from the trapezius muscle have revealed a consistent finding of so-called moth-eaten fibers Bengtsson et al, 1986;Yunus et al, 1986;Larsson et al, 1988). We recently found that in the trapezius muscle of males such fibers seemed to be located only in the descending portion of the muscle.…”

Section: Discussionmentioning

confidence: 69%

Fiber type composition of the human female trapezius muscle: Enzyme‐histochemical characteristics

1991

View full text Add to dashboard Cite

Tne anatomy of the human trapezius muscle is complex, with an extensive origin and fibers running in different directions. The muscle is commonly divided into three different muscle portions according to the fiber direction: the descending, transverse, and ascending portions. In a previous study in males, the structure of the muscle differed between different portions with respect to the enzyme-histochemical fiber-type profile. The lower regions of the descending portion and the transverse and the ascending portions had a predominance of type I fibers. The type II fibers were more frequent in the upper regions of the descending portion, and the cross-sectional fiber area in this region of the muscle was smaller. In this study, we have investigated the trapezius muscle in females and compared the results with those from males. The different portions of the female muscle had a relatively even fiber-type composition. However, there tended to be fewer type I fibers and more type IIB fibers in the descending portion of the muscle, and the fibers of the lower regions of the descending portion were somewhat larger. The fiber-type distribution pattern was similar to that of the male trapezius muscle, but the mean cross-sectional area of the fibers in the female muscle was considerably smaller. Thus, our conclusion is that the trapezius muscle of females has a similar activity pattern as that of males. The significantly smaller cross-sectional fiber area, however, may indicate a lower functional capacity which may be of importance in the development of neck and shoulder dysfunction in females.

show abstract

Section: Discussionmentioning

confidence: 69%

Fiber type composition of the human female trapezius muscle: Enzyme‐histochemical characteristics

1991

View full text Add to dashboard Cite

show abstract

“…8,29 Moreover, since mitochondria supply energy to the cell thorough oxidative phosphorylation, the lower level of ATP that results from a low mitochondrial activity may explain the low exercise capacity and fatigue reported in patients with fibromyalgia. 30 Vitamin A and b-carotene are fat-soluble vitamins and appear to protect cells against inflammatory disease, perhaps by their antioxidant properties. 31 Although their protective role inflammatory diseases in humans is not completely understood, the available evidence suggests that vitamin A and b-carotene metabolism are linked to vitamin E as an antioxidant in the stability of biological membranes.…”

mentioning

confidence: 99%

Levels of lipid peroxidation, nitric oxide, and antioxidant vitamins in plasma of patients with fibromyalgia

Akkuş

Nazıroğlu

Eriş

et al. 2009

Cell Biochemistry & Function

View full text Add to dashboard Cite

The etiology of fibromyalgia is not clearly understood. In recent years, a few studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of fibromyalgia. The aim of this study was to investigate plasma antioxidant vitamins, lipid peroxidation (LP), and nitric oxide (NO) levels in patients with fibromyalgia and controls. The study was performed on the blood plasma of 30 female patients and 30 age-matched controls. After a fast of 12 h, blood samples were taken, and plasma samples were obtained for measurement of vitamins A, C, E, and beta-carotene concentrations and levels of LP and NO. Concentrations of vitamins A (p < 0.01) and E (p < 0.001) were significantly lower in patients with fibromyalgia than in controls, and LP levels were significantly (p < 0.05) higher in the plasma of the patients than in controls. Concentrations of vitamin C and beta-carotene and levels of NO did not change significantly. These results provide some evidence for a potential role of LP and fat-soluble antioxidants in the patients with fibromyalgia.

show abstract

“…However, one of the suggested mechanisms for the pathogenesis of FMS is the influence of local hypoxia due to disturbed microcirculation leading to vasoconstriction in the skin of tender points [37]. It's well known that hypoxia may result in both ROS production and decreased antioxidant levels and efficacy, which may contribute to the signs and symptoms of FMS related to oxidative stress [38]. There are numerous studies indicating that ROS-induced muscle and neuron damages have an important role in the pathophysiology of muscular disorders.…”

Section: Discussionmentioning

confidence: 99%