Pathogenetic therapy of rhinosinusites in the practice of otorhinolaryngologist

Рязанцев, С. В.; Fanta, I. V.; Pavlova, S. S.

doi:10.21518/2079-701x-2019-6-68-73

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Специально разрабо- танные устройства для ирригационной терапии позволяют осуществлять равномерное орошение (увлажнение) слизистой оболочки и промывание полости носа под разным давлением и с различной интенсивностью. Накоплен достаточный опыт использования указанных растворов в комплексном лечении острого риносинусита у взрослых и детей, при сочетании риносинусита с тубарной дисфункцией и аденоидитом, в качестве профилактики заболеваемости в сезон ОРВИ [36][37][38][39]. С помощью элиминационно-ирригационной терапии происходит механическое удаление из носовых ходов и со слизистой оболочки полости носа частиц пыли, сгустков слизи, корок, патогенов и аллергенов, продуктов воспаления.…”

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New active elimination-irrigation intranasal therapy as a pathogenetically substantiated method for the prevention and treatment of recurrent and chronic rhinosinusitis

Артюшкин

Еремина

2020

Ross. vestn. perinatol. pediatr.

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Распространенность синусита/риносинусита составляет 10-30% в общей популяции, хронические формы диагностируются у 5-15% взрослого населения и у 5% детей. В патогенезе важную роль играют образующиеся биопленки, затрудняющие лечение больных, особенно рецидивирующим и хроническим риносинуситом. Новая активная элиминационно-ирригационная интраназальная терапия с применением средства «Аквалор ® Актив софт», содержащего газированный изотонический раствор стерильной морской воды (концентрация NaCl 0,9%; концентрация СО 2 0,4%) обеспечивает разрушение биопленок и значительное снижение микробной нагрузки, что целесообразно использовать при лечении больных риносинуситом, особенно рецидивирующего и хронического течения.Ключевые слова: дети, хронический риносинусит, рецидивирующий риносинусит, ирригационно-элиминационная терапия, газированный изотонический раствор стерильной морской воды, «Аквалор ® Актив софт».

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New active elimination-irrigation intranasal therapy as a pathogenetically substantiated method for the prevention and treatment of recurrent and chronic rhinosinusitis

Артюшкин

Еремина

2020

Ross. vestn. perinatol. pediatr.

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Improvement of Bacterial Rhinosinusitis Diagnostic Procedures

2020

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The research included evaluation of express-diagnosis capability of immunochromatographic assay (ICA) Binax NOW (Alere, Inc., USA) for diagnosis of the rhinosinusitis caused by to detect the Streptococcus pneumoniae antigen directly in clinical samples. The unique feature of the method included obtaining samples with an electric suction machine in order to evaluate aspirate from deep parts of the nasal cavity. Diagnostic capability of the Binax NOW was determined in a comparative study using classical bacteriological method in 100 clinical samples. Pneumococcus was isolated in 16 patients (16±3,7%) via bacteriological method. ICA utilization allowed to reveal pneumococcal antigen in 20 cases (20±4,0%). ICA test sensitivity equaled 87,5%, specificity - 92,9%. Obtained results allow us to recommend ICA for identification of pneumococcal infection in patients with sinusitis for practicing physicians. The advantages of the evaluated method were fast results (for up to 15 min) and possibility of non-invasive sampling technique of clinical specimens.

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Local treatment of acute rhinosinusitis in the era of COVID-19

2022

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Introduction. Acute rhinosinusitis accounts for 40 % to 60 % of the morbidity in the structure of ENT pathology. COVID-19 pathogen, similarly to other respiratory viruses, can cause acute rhinosinusitis, which is the most relevant at the present time due to the ongoing pandemic. Viral etiology accounts for 90–98 % of all cases of acute rhinosinusitis. Accordingly, the choice of treatment tactics with antibacterial drugs in a number of cases is unreasonable and leads to the growth of antibiotic resistance. Local antiseptics containing sodium hypochlorite with a high safety profile that do not cause pathogen resistance are used to increase the effectiveness of therapy for acute rhinosinusitis. Objective. To evaluate the effectiveness of nasal spray containing sodium hypochlorite on the duration of the course of exacerbation and severity of acute rhinosinusitis during the epidemiological season. Materials and methods. The study involved 50 patients who were divided into 3 groups: 10 patients (group 1) with acute viral rhinosinusitis (therapy: sodium hypochlorite + decongestants); 20 patients (group 2) with acute bacterial rhinosinusitis (therapy: sodium hypochlorite + systemic antibacterial therapy); 20 patients (group 3) with acute bacterial rhinosinusitis (therapy: nasal lavage with isotonic sea salt solution + systemic antibacterial therapy). Results and discussion. Pathogen eradication – the absence of the original pathogen at the locus of the inflammatory process during dynamic microbiological examination – was found in 14 (35 %) clinical cases: in Group 2 (sodium hypochlorite) – 10 (25 %) and in Group 3 (nasal irrigation with isotonic sea water solution) – 4 (10 %). Conclusions. The results of microbiological studies showed effective antimicrobial properties of sodium hypochlorite when applied to the inflamed mucous membranes, expressed in a statistically significant reduction of bacterial semination of the nasal cavity epithelium.

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Pathogenetic therapy of rhinosinusites in the practice of otorhinolaryngologist

Cited by 4 publications

References 8 publications

New active elimination-irrigation intranasal therapy as a pathogenetically substantiated method for the prevention and treatment of recurrent and chronic rhinosinusitis

New active elimination-irrigation intranasal therapy as a pathogenetically substantiated method for the prevention and treatment of recurrent and chronic rhinosinusitis

Improvement of Bacterial Rhinosinusitis Diagnostic Procedures

Local treatment of acute rhinosinusitis in the era of COVID-19

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