Pathogenesis of So-Called Diffuse Vascular or Collagen Disease

Rheumatoid Arthritis with Lung Lesions

“…In nine of these cases (Ellman and Ball, 1948 ;Eliman, 1947;Rubin, 1955;Katz and Auerbach, 1951 ;Yardumian and Kleinerman, 1949;Ellman, 1956) the histological changes consisted of a non-specific fibrosing pneumonitis of the same general pattern as we have described in our two cases. In one case described by Price and Skelton (1956) the lesions appear to have been confined to the blood vessels, whilst the remaining 12 cases (Ellman and others, 1954;Raven and others, 1948;Christie, 1954;Bevans and others, 1954;Skogrand, 1956;Gruenwald, 1948;Bennett and others, 1940) have been characterized by the appearance of nodular necrobiotic foci of rheumatoid type, showing a close histological resemblance to the more commonly encountered subcutaneous lesions frequently seen in the region of the elbow joints of patients with rheumatoid arthritis.…”

“…Including the present two cases, 43 cases of nonpneumoconiotic rheumatoid lung disease have now been described; in six of these the diagnosis was established by biopsy (Rubin, 1955 ;Ellman, 1956) and in a further 18 cases by necropsy (Ellman and Ball, 1948;Ellman, Cudkowicz, and Elwood, 1954;Ellman, 1947;Price and Skelton, 1956;Raven, Parkes Weber, and Price, 1948;Christie, 1954;Bevans, Nadell, Demartini, and Ragan, 1954;Katz and Auerbach, 1951 ;Skogrand, 1956;Yardumian and Kleinerman, 1949;Gruenwald, 1948 ;Bennett, Zeller and Bauer, 1940). In nine of these cases (Ellman and Ball, 1948 ;Eliman, 1947;Rubin, 1955;Katz and Auerbach, 1951 ;Yardumian and Kleinerman, 1949;Ellman, 1956) the histological changes consisted of a non-specific fibrosing pneumonitis of the same general pattern as we have described in our two cases.…”

A Review of Cases of Polyarteritis Nodosa : With Special Reference to the Pathology

“…In the case of J.P., whose history of the acute attack was of only two months, but who on the two preceding winters had had pneumonia treated with sulphonamide, it is conjectured that the presence of many fibrosed and hyalized glomeruli, and of apparently arteriosclerotic change would be, in fact, the result of a very slow process of the polyarteritis type. Attempts have been made to classify the lesions into grades of severity by Y ardumian and Kleinermann (1949). They consider that the hyalinization, fibrosis and deposition of collagenous substance represent a type of repair, replacing the damaged tissue, and where the process is slow and insidious, with exacerbations, damage progresses slowly with healing between exacerbations.…”

Case of Rheumatoid Lung with Cavity Formation

“…Necropsies were performed in about 20 cases. Histological changes of non-specific pulmonary fibrosis were described in the cases reported by Yardumian and Kleinerman (1949), Bevans et al (1954), Ellman and Ball (1948), Christie (1954( ), Ellman (1956, Price andSkelton (1956), Brinkman andChaikof (1959), Gardner et al (1957), Edge andRickards (1957), Smith andRothermich (1957), Dixon and Ball (1957), Horler and Thompson (1959), and Ognibene (1960).…”