bletween small and large, but not between small and medium dogs. No sex difference was found within any single weight group of adult animals. Although the number of senile animals was smalI, their relative hypophysis size was distinctly (33 3 % ) and significantly less than that of adults. No significant differences were found in water content of the hypophysis (range, 82.25% to 83.88%).Discussion. The observations of relative hypophysis weights in pups and in adults, as far as SEX difference is concerned, confirm those of other workers. Hypophysis weight seems subject to gonadal influence, being increased in the female by estrus( l l ) , pregnancy( l o ) , and the injection of chorionic gonadotr
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