Effect of Insulin Hypoglycemia on Eosinophiles and Lymphocytes of Psychotics.

Abstract

bletween small and large, but not between small and medium dogs. No sex difference was found within any single weight group of adult animals. Although the number of senile animals was smalI, their relative hypophysis size was distinctly (33 3 % ) and significantly less than that of adults. No significant differences were found in water content of the hypophysis (range, 82.25% to 83.88%).Discussion. The observations of relative hypophysis weights in pups and in adults, as far as SEX difference is concerned, confirm those of other workers. Hypophysis weight seems subject to gonadal influence, being increased in the female by estrus( l l ) , pregnancy( l o ) , and the injection of chorionic gonadotr<ophin, theelin and theeIol ( 1 2 ) . The hypophysis of the male is not influenced, however, by the ad ministration of testosterone. 11. Aiidersen, D. H., PROC. SOC. EXP. BIOL. AND 12. Leiby, G. M.. P R O P . SOC. E-xP. BIOL. AND MED., 1933, v30, 657. MED., 1933, 1-31, 14.I t would be expected, therefore, that the female hypophysis would be heavier.Constancy of water content of the hypophysis in the several groups suggests that fluid shifts into and out of the gland are not important effects upon its relative weight. It would be of interest to study water content of the hypophysis in (estrous females.1. I t is confirmed in the dog, as has been shown for other species, that the relative weight of the hypophysis is greater in adult females than in adult mal'es, and that this difference does not exist before maturity. 2. The hypophysis weight-body weight ratio of puppies is greater than that of adult dogs, and in adult dogs decreases significantly with increase in body size. 3. Relative hypophysis weight was smaller in senile than in adult animals. 4. 50 sex difference in hypophysis weight existed within any weight-group of adult animals. 5. No differences between groups could be detected with respect to water content of the hypophysis.

A Metabolic Study of a Diabetic Patient: The Effect of Variations in the Dosage of Insulin Upon Adrenal Cortical Activity and Upon Water, Electrolyte and Nitrogen Excretion 1

“…Of the various metabolic abnormalities which might produce hyperfunction and ultimate attrition of the adrenal cortex in diabetic patients, instability in the control of the blood sugar level appeared to us to merit primary consideration inasmuch as hypoglycemia and hyperglycemia, states between which the diabetic patient oscillates continuously, are both capable of stimulating the adrenal cortex (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). The present study was designed to determine whether there was any relation between the degree of control of blood sugar and the level of adrenal cortical activity.…”