Effects of Acth in Patients With Mental Disease

Altschule, Mark D.

doi:10.1001/archneurpsyc.1950.02310290037004

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1951

1954

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Cited by 27 publications

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“…A number of reports exist which also suggest a greater disturbance in carbohydrate metabolism after ACTH or cortisone under conditions of "stress" as compared with normals, notably in schizophrenia (36), liver disease (37) and pregnancy (38), although in none of these reports are there really adequate control studies. Appel and associates (39) described impaired insulin tolerance after four hours intravenous infusion of ACTH in patients who previously had normal insulin and glucose tolerance tests.…”

Section: Discussionmentioning

confidence: 99%

Studies on the Interdependent Effects of Stress and the Adrenal Cortex on Carbohydrate Metabolism in Man 1

Burns¹,

Engel²,

Viau³

et al. 1953

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

Studies on the Interdependent Effects of Stress and the Adrenal Cortex on Carbohydrate Metabolism in Man 1

Burns¹,

Engel²,

Viau³

et al. 1953

J. Clin. Invest.

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Observations on Effect of Corticotrophin in Schizophrenia

Glaser¹

1951

AMA Arch NeurPsych

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RECENT investigations by Hoagland and Pincus 1 have emphasized the defective physiological responses of the schizophrenic patient to adrenocortical stimulation. Altschule and co-workers 2 have reported essentially normal physiological responses to corticotrophin in schizophrenic patients, with the exception of suggestive greater-than-normal changes in glucose tolerance. In an attempt to evaluate the relationship between adrenocortical activity and the psychological state, we administered corticotrophin in large doses to six patients (three men and three women) with schizophrenia. Significant data concerning these patients are presented in the accompanying table.All the patients were observed in a control period varying from two to four weeks before the administration of the corticotrophin. The influence of placebos and other drugs, such as amobarbital (amytal\s=r\),d-desoxyephedrine hydrochloride (per-vitin\s=r\),amphetamine, and mescaline, was studied during the control period, or after From the

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