Paternal drug use: before and during pregnancy

Crijns, Ineke; Bos, Jens; Knol, Mariska; Straus, Sabine M. J. M.; Berg, Lolkje Theodora Wilhelmina de Jong-van den

doi:10.1517/14740338.2012.674109

Cited by 10 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding medications, there is a scarce knowledge of the effects of paternal preconception medication use on the offspring. Mercaptopurine and azatiopurine, anti-inflammatories, antihypertensives, antipsychotics and drugs for acid-related disorders, when used in the preconception period, are associated with the onset of pregnancy complications and birth defects, including hypospadias [ 32 , 39 ]. Contradictory results have emerged from other studies [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users

et al. 2016

View full text Add to dashboard Cite

BackgroundPaternal preconception risk factors such as smoking, exposure to environmental substances, medication use, overweight and advanced age correlate with the occurrence of malformations and birth defects in the offspring. Nonetheless, the prevalence of risk factors for adverse pregnancy outcomes in the male population has been scarcely investigated and no report on preconception interventions targeting prospective fathers is available. We conducted a web-based survey to measure the prevalence of paternal preconception risk factors for adverse pregnancy outcomes in an Italian population of Internet users.MethodsProspective or expectant fathers were enrolled during a four-week period through two of the main Italian web-sites dedicated to preconception, pregnancy, childhood and family care. Participants filled in a web questionnaire regarding preconception risk factors for adverse pregnancy outcomes. Logistic regression analysis was used to explore the predictors of paternal preconception risk factors.ResultsWe enrolled 131 prospective and 205 expectant fathers. More than half of the total participants used medications during the preconception period, 35 % were smokers and 8 % were obese. Exposure to environmental substances was declared by almost 20 % of the participants, with the group including pesticides/herbicides/professional paints being the most prevalent. More than a half of the study sample included men aged over 35 years.According to the multivariate analysis, smoking and exposure to environmental toxics were less frequent among individuals with a university degree (respectively: OR = 0.52; 95 % CI 0.32–0.84; OR = 0.52; 95 % CI 0.29–0.93). Paternal obesity and medication use in the preconception period were not associated with any of the independent variables.ConclusionsThe prevalence of preconception risk factors among male population should not be neglected when planning preconception interventions, confirming that preconception health must be focused on the couple, rather than on women only.Electronic supplementary materialThe online version of this article (doi:10.1186/s12978-016-0156-6) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Paternal drug use may influence male fertility . However, no information on male fertility was available.…”

Section: Discussionmentioning

confidence: 99%

“…in addition to paternal use of any of these drugs and any drugs at all. Also analyses for paternal use of selective serotonin re‐uptake inhibitors (SSRIs) were performed .…”

Section: Methodsmentioning

confidence: 99%

“…The frequency of adverse pregnancy outcomes were analyzed for the two most frequent/common drugs in the list by Schirm et al in addition to paternal use of any of these drugs and any drugs at all. Also analyses for paternal use of selective serotonin re-uptake inhibitors (SSRIs) were performed [14].…”

Section: Exposuresmentioning

confidence: 99%

“…Odds ratios (ORs) with 95% confidence intervals (CI) from multivariate logistic regression, of dispensed drugs to fathers during the last 3 months prior to conception, for birth defect in some major organ systems, adjusted for maternal and paternal age (n = 279 796) Effects of paternal drug exposure on birth outcomes Paternal drug use may influence male fertility [14,20]. However, no information on male fertility was available.…”

Section: Tablementioning

confidence: 99%

See 2 more Smart Citations

Effects of preconceptional paternal drug exposure on birth outcomes: cohort study of 340 000 pregnancies using Norwegian population‐based databases

Engeland

Bjørge

Daltveit

et al. 2013

Brit J Clinical Pharma

View full text Add to dashboard Cite

AIMSWe aimed to explore associations between drugs dispensed to the father prior to conception and pregnancy outcomes, such as pre-term birth, perinatal mortality, foetal growth retardation and birth defects. METHODSIn this cohort study, two population-based registries, the Medical Birth Registry of Norway and the Norwegian Prescription Database, were linked. The study cohort consisted of 340 000 pregnancies in 2004-10. The association between specific drugs dispensed to the fathers during the last 3 months prior to conception and pregnancy outcomes was explored by estimating odds ratios (ORs) using multivariate logistic regression. RESULTSAbout one quarter (26%) of the fathers were dispensed at least one drug during the last 3 months prior to conception and 1.3% were dispensed at least one drug requiring special attention. Overall, the odds of different adverse pregnancy outcomes were not increased when the father had been dispensed drugs, i.e. the OR and 95% confidence intervals (CIs) for any birth defect when the fathers had been dispensed any drug were 0.99 (0.94, 1.0). When the fathers had been dispensed diazepam we found increased risk of perinatal mortality and growth retardation, with OR and 95% CIs of 2.2 (1.2, 3.9) and 1.4 (1.2, 1.6), respectively. CONCLUSIONSLarge studies are necessary to reveal increased risk of rare outcomes as specific birth defects. Our study did not indicate that paternal drug exposure is an important risk factor for adverse pregnancy outcomes.

show abstract

Investigation of the risk factors of anorectal malformations

Wang

Bi³

et al. 2021

Birth Defects Research

View full text Add to dashboard Cite

Purpose To investigate the factors that influence the occurrence of anorectal malformations (ARMs). Methods From December 2018 to December 2019, 136 children treated for ARMs at the Children's Hospital of Chongqing Medical University were included in the case group. The control group consisted of children with intussusception or perianal abscesses. A uniform questionnaire was filled by the parents of the enrolled children. Results The birth weight of the cases was significantly lower than that of the controls (p < .01), and children with ARMs were more likely to be complicated with single umbilical artery (SUA) (p < .001). Maternal upper respiratory tract infection (adjusted odds ratio [ORadj], 2.44; 95% confidence interval [CI], 1.29–4.63) and urogenital infection (ORadj, 2.67; 95% CI 1.11–6.38) during the first trimester of pregnancy, anemia during pregnancy (ORadj, 5.69; 95% CI, 1.01–32.07), and exposure to hazardous substances 6 months before pregnancy and during the first trimester of pregnancy (ORadj, 13.82; 95% CI, 3.86–49.35) are associated with increased risk of ARMs. Folic acid supplements (ORadj, 0.31; 95% CI, 0.14–0.65) and multivitamin (ORadj, 0.34; 95% CI, 0.15–0.79) had a protective effect on ARMs. Paternal drug use (ORadj, 9.17; 95% CI, 2.19–38.49) 6 months before their wives' conception increased the risk of ARMs. Conclusion Maternal infection, anemia during pregnancy, and maternal hazardous substances exposure are possible risk factors for ARMs. Folic acid supplements and multivitamin can reduce the occurrence of ARMs. Meanwhile, paternal drug use may also be a risk factor for ARMs.

show abstract

Paternal drug use: before and during pregnancy

Cited by 10 publications

References 29 publications

Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users

Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users

Effects of preconceptional paternal drug exposure on birth outcomes: cohort study of 340 000 pregnancies using Norwegian population‐based databases

Investigation of the risk factors of anorectal malformations

Contact Info

Product

Resources

About