Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users

Agricola, Eleonora; Gesualdo, Francesco; Carloni, Emanuela; D’Ambrosio, A; Russo, Luisa; Campagna, Ilaria; Pandolfi, Elisabetta; Tozzi, Alberto Eugenio

doi:10.1186/s12978-016-0156-6

Cited by 18 publications

(19 citation statements)

References 53 publications

(42 reference statements)

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“…via biological effects in sperm) and indirect (e.g. via influence on the mother) paternal effects in DOHaD ( Agricola et al, 2016 ; Braun et al, 2017 ; Day et al, 2016 ; Romanus et al, 2016 ; Soubry, 2017 ). This goes hand-in-hand with developing and implementing strategies to collect better-quality, more complete data on partners.…”

Section: Strategies To Maintain a Critical Perspectivementioning

confidence: 99%

It's the mother!: How assumptions about the causal primacy of maternal effects influence research on the developmental origins of health and disease

Sharp

Lawlor

Richardson

2018

Social Science & Medicine

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Research on the developmental origins of health and disease (DOHaD) has traditionally focused on how maternal exposures around the time of pregnancy might influence offspring health and risk of disease. We acknowledge that for some exposures this is likely to be correct, but argue that the focus on maternal pregnancy effects also reflects implicit and deeply-held assumptions that 1) causal early life exposures are primarily transmitted via maternal traits or exposures, 2) maternal exposures around the time of pregnancy and early infancy are particularly important, and 3) other factors, such as paternal factors and postnatal exposures in later life, have relatively little impact in comparison. These implicit assumptions about the “causal primacy” of maternal pregnancy effects set the agenda for DOHaD research and, through a looping effect, are reinforced rather than tested. We propose practical strategies to redress this imbalance through maintaining a critical perspective about these assumptions.

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Section: Strategies To Maintain a Critical Perspectivementioning

confidence: 99%

It's the mother!: How assumptions about the causal primacy of maternal effects influence research on the developmental origins of health and disease

Sharp

Lawlor

Richardson

2018

Social Science & Medicine

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“…There was a notable absence of the concept of the "preconception population" in the literature, however the term "preconception" was broadly used in the context of women's health before or around pregnancy or conception. For example, some documents focused on preconception care and related needs [41,42], while others were focused on preconception health as a concept [11,22]. Studies tended to define preconception as a time period rather than a population, for example referring to women before conception [33] or before a pregnancy [24,28], or using "time to pregnancy" as a measure of the preconception period [33].…”

Section: Recruitment Methodsmentioning

confidence: 99%

“…Regarding inclusion criteria of participants, most studies specified recruitment of women only (n = 13), with one solely recruiting men [22]. Age criteria varied, albeit most (n = 12) studies recruited participants aged 18 to 45 years.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…Clinic/hospital settings included premarital clinics (n = 2)[23,30], preconception clinics (n = 2)[21,31], obstetric/gynaecological clinics (n = 2)[20,29], general hospital setting (n = 1)[32], health centres (n = 2)[24,32], ART clinic (n = 1)[20], and a women's clinic (n = 1)[35]. Recruitment from the general population occurred primarily via the Internet/websites (n = 5)[22,25,26,34,36], social media (n = 5)[20,22,25,34,35], posters/flyers in the community (n = 3)[20,25,26], television, print or radio media (n = 2)[25,26], or word of mouth (n = 2)[20,36].Stage 2: concept analysis Steps 1 and 2: select a concept and determine the aims or purposes of analysis…”

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confidence: 99%

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Defining preconception: exploring the concept of a preconception population

Hill

Hall

Skouteris

et al. 2020

BMC Pregnancy Childbirth

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Background: Health prior to conception can significantly impact offspring health, however, a clear definition of the attributes of the preconception population is currently lacking. We aimed to use existing literature to explore the concept and attributes of a preconception population by: [1] identifying characteristics and research recruitment methods; and [2] generating an attribute-based working definition of a preconception population. Methods: A rapid review of current literature using CINAHL and the subject heading 'pre-pregnancy care' was conducted (Stage 1). Data extracted included definitions of preconception, participant inclusion/exclusion criteria, participant characteristics, and recruitment methods. Stage 2 involved a wider search of relevant publications beyond peer-reviewed literature followed by a concept analysis of the phrase "preconception population" applying Walker and Avant's framework (Stage 2). Results: Twenty-three papers (19 studies) were included in Stage 1. "Preconception" was explicitly defined in one study. Twelve studies specified participants must be planning a pregnancy. Stage 2 included 33 publications. Four key perspectives for the concept of the preconception population were derived: [1] intentional; [2] potential; [3] public health; and [4] life course. Conclusions: Adopting these perspectives may allow researchers to accurately define, identify and recruit preconception populations and to develop interventions that are appropriately broad or tailored depending on population needs. We hope the definitions will facilitate research with this population and will subsequently improve the wellbeing of preconception men and women, which is essential to ensuring the health of future generations.

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“…While the data on pregnancy are limited, we know little about paternal drug exposure. Paternal obesity, age and smoking are associated with a low increase of risk; but it is remarkable that after decades of chemotherapy research, no single drug has been identified that causes malformations in offspring after paternal exposure, although they may cause infertility.…”

mentioning

confidence: 99%