Patch test reactivity to iodopropynyl butylcarbamate in consecutive patients during a period of 7 years

Batista, Mariana; Morgado, Francisca; Gonçalo, Margarida

doi:10.1111/cod.13213

Cited by 8 publications

(10 citation statements)

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“…However, other studies found a lower sensitization prevalence (eg, 0.53%). 57 IPBC liberates iodine, which has also been supported by observing simultaneous contact allergy to IPBC and iodine. 58 Owing to possible endocrine interference, use concentrations are restricted to between 0.02% in rinse-off products and 0.0075% in deodorants/antiperspirants for many years (SCCNFP/0826/04, EU Cosmetics Regulation, Annex V/56).…”

Section: Additional Consecutively Tested Allergensmentioning

confidence: 68%

“…Iodopropynyl butylcarbamate (IPBC) 0.2% pet., tested in more than 20 000 consecutive patients, caused over 1% positive, mostly weak positive, reactions and about three times as many doubtful or irritant reactions. However, other studies found a lower sensitization prevalence (eg, 0.53%) 57 . IPBC liberates iodine, which has also been supported by observing simultaneous contact allergy to IPBC and iodine 58 .…”

Section: Discussionmentioning

confidence: 85%

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Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

et al. 2020

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Background Clinical surveillance of the prevalence of contact allergy in consecutively patch tested patients is a proven instrument to continually assess the importance of contact allergens (haptens) assembled in a baseline series. Objectives To present current results from the European Surveillance System on Contact Allergies, including 13 countries represented by 1 to 11 departments. Methods Anonymized or pseudonymized patch test and clinical data from various data capture systems used locally or nationally as transferred to the Erlangen data centre were pooled and descriptively analysed after quality control. Results In the 4 years (2015‐2018), data from 51 914 patients patch tested with the European baseline series (EBS) of contact allergens were analysed. Contact allergy to nickel was most frequent (17.6% positive), followed by contact allergy to fragrance mix I (6.9%), methylisothiazolinone (MI; 6.2%), and Myroxylon pereirae resin (balsam of Peru; 5.8%). Conclusions While the prevalence of MI contact allergy decreased substantially following regulatory intervention, the persistently high levels of allergy to metals, fragrances, other preservatives, and rubber chemicals point to problems needing further research and, potentially, preventive efforts. Results with national additions to the baseline series provide important information on substances possibly to be considered for inclusion in the EBS.

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Section: Additional Consecutively Tested Allergensmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 85%

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

et al. 2020

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“…IPBC, patch tested 0.2% pet., is used as a preservative (mainly fungicide) in industrial applications, for example, wood protective agents, pulp in paper production, water‐based paints, or water‐based MWFs, 9,23,24 as well as in household products, cosmetics, and body care products. In earlier studies from 2000 to 2003, we found sensitization to IPBC in less than 1% of the metalworkers with OD who were tested with the metalworking series 7,25,26 .…”

Section: Discussionmentioning

confidence: 99%

Contact sensitization in metalworkers: Data from the information network of departments of dermatology (IVDK), 2010–2018

et al. 2020

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Background: Metalworkers are exposed to a variety of contact allergens by handling tools, metals, metalworking fluids (MWFs), oils and greases, rubber materials, and so on. Most large-scale reports on contact allergy due to MWFs are more than 10-years-old, and there are only few studies on contact allergy in mechanics and other metal workers not exposed to MWFs. Objectives: To describe a current spectrum of contact sensitization in metalworkers with occupational dermatitis (OD). Patients and Methods: Retrospective analysis of patch test data collected by the Information Network of Departments of Dermatology (IVDK; 2010-2018), stratifying for 804 cutting metalworkers, 2197 mechanics, and 355 other metalworkers. Results: Cutting metalworkers were most frequently sensitized to monoethanolamine (12.6%), colophonium/abietic acid (11.4%) and formaldehyde releasers (up to 8.5%) from the MWF series, and formaldehyde (4.6%) and iodopropynyl

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“…In the case of iodopropynyl butylcarbamate (IPBC), it is iodine liberation and systemic availability that led the EU to limit the use concentration to 0.02% in rinse-off, 0.01% in leave-on cosmetics and 0.0075% in deodorants, see (EC) No 1223/2009. The recent observation of frequent concomitant allergic reactions to IPBC and iodine [340] supports this cautionary approach, pointing to a relevant co-exposure to both IPBC, which is a contact allergen in its own right [341], and (liberated) iodine.…”

Section: Allergen-specific Aspectsmentioning

confidence: 97%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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Patch test reactivity to iodopropynyl butylcarbamate in consecutive patients during a period of 7 years

Cited by 8 publications

References 8 publications

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

Patch test results with the European baseline series and additions thereof in the ESSCA network, 2015‐2018

Contact sensitization in metalworkers: Data from the information network of departments of dermatology (IVDK), 2010–2018

Contact Allergy—Emerging Allergens and Public Health Impact

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