Pasteurella multocida type A as the primary agent of pneumonia and septicaemia in pigs

Abstract

In order to understand better the pathological aspects and spread of Pasteurella multocida type A as the primary cause of pneumonia in pigs, was made an experiment with intranasal inoculation of different concentrations of inocula [Group (G1): 108 Colony Forming Units (CFU)/ml; G2: 107 CFU/ml; G3: 106 CFU/ml and G4: 105 CFU/ml], using two pigs per group. The pigs were obtained from a high health status herd. Pigs were monitored clinically for 4 days and subsequently necropsied. All pigs had clinical signs and lesions associated with respiratory disease. Dyspnoea and hyperthermia were the main clinical signs observed. Suppurative cranioventral bronchopneumonia, in some cases associated with necrosuppurative pleuropneumonia, fibrinous pericarditis and pleuritic, were the most frequent types of lesion found. The disease evolved with septicaemia, characterized by septic infarctions in the liver and spleen, with the detection of P. multocida type A. In this study, P. multocida type A strain #11246 was the primary agent of fibrinous pleuritis and suppurative cranioventral bronchopneumonia, pericarditis and septicaemia in the pigs. All concentrations of inoculum used (105-108 CFU/ml) were able to produce clinical and pathological changes of pneumonia, pleuritis, pericarditis and septicemia in challenged animals.

Genotypic diversity of Pasteurella multocida isolates from pigs and poultry in Australia

“…This co‐infection status makes it hard to attribute symptoms in pigs associated with P. multocida , because the clinical signs and lesions are normally superimposed on that of the primary agent . Recent challenge studies have shed light on the symptoms of pneumonia in pigs, with dyspnoea and hyperthermia being the main clinical symptoms . As well, P. multocida in pigs is associated with progressive atrophic rhinitis, with obvious symptoms including shortening and twisting of the snout …”

“…3 Recent challenge studies have shed light on the symptoms of pneumonia in pigs, with dyspnoea and hyperthermia being the main clinical symptoms. 4 As well, P. multocida in pigs is associated with progressive atrophic rhinitis, with obvious symptoms including shortening and twisting of the snout. 1 In the Australian context, somatic Heddleston serotyping, lipopolysaccharide (LPS) genotyping and repetitive element PCR fingerprinting (rep-PCR) are being used to guide autogenous vaccine use in the poultry industry.…”

Identificação de transcritos diferencialmente expressos por Pasteurella multocida em condições de privação de ferro

“…O isolado de Pasteurella multocida (Pm 16759), sorotipo A foi obtido de uma lesão de pleuropneumonia fibrinonecrossupurativa focalmente extensa acentuada de um suíno livre de patógeno específico (Specific Pathogen Free -SPF), previamente inoculado com a cepa BRMSA 1113 no estudo realizado por Oliveira Filho et al (2015).…”

Polyserositis Associated with Pasteurella Multocida Type A in a Crossbred Pig

“…Page269 septicemia (Oliveira Filho et al, 2015) and type D is associated with atropic rhinitis (Pijoan and Trigo, 1990). In pigs P multocida type B is mainly involved in causing septicemia and generalized infection (Townsend et al, 1998;Cardoso-Toset et al, 2013).…”

“…In pigs P multocida type B is mainly involved in causing septicemia and generalized infection (Townsend et al, 1998;Cardoso-Toset et al, 2013). Earlier Pasteurella spp was mainly considered as a secondary opportunistic pathogen in Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae and swine influenza virus infections in pigs (Little and Harding, 1980) but recent report suggesting its action as a primary etiological agent in pig in experimental studies results in fibrinous pleuritis and suppurative cranioventral bronchopneumonia, pericarditis and septicaemia in the pigs (Oliveira Filho et al, 2015). In the present study we report the pathology, diagnosis and cultural characteristic of polyserositis associated with P multocida type A in a cross bred pig.…”