Pasteurella Multocida Epiglottitis: A Review and Report of a New Case with Associated Chronic Lymphocytic Leukemia

Harris, Penelope J; Osswald, Michael B.

doi:10.1177/014556131008901202

Cited by 13 publications

(16 citation statements)

References 11 publications

(21 reference statements)

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“…Indeed, our data are consistent with several case reports that have described bacteremia occurring predominantly in patients with preexisting liver disease or in immunosuppressed patients. 1 , 2 , 8 , 9 , 14 , 17 , 19 – 21 …”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcomes of Pasteurella multocida Infection

et al. 2015

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Pasteurella multocida, a zoonotic infectious organism, has most often been described in patients after an animal bite. Here, we characterize the clinical features and outcomes of P multocida infection in a large cohort of patients according to the presence or absence of an animal bite.We retrospectively searched MUSC's laboratory information system for all patients with positive P multocida cultures from 2000 to 2014. Extensive data were abstracted, including clinical and outcome data. The Charlson comorbidity index (CCI) was used to assess comorbidities among patients.We identified 44 patients with P multocida infections, including 25 with an animal bite. The average age was 64 years and the majority of patients were women (N = 30). There was no difference in age and sex distribution among those with and without a bite (P = 0.38 and 0.75, respectively). A CCI ≥1 was significantly associated with the absence of a bite (P = 0.006). Patients presenting without a bite were more frequently bacteremic (37% vs 4%, respectively, P = 0.001), and were hospitalized more often (84% vs 44%, respectively, P = 0.012). Of the 8 patients who required intensive care unit (ICU)-based care, 7 were non-bite-related. There were 4 deaths, all occurring in patients not bitten.P multocida infections not associated with an animal bite were often associated with bacteremia, severe comorbidity(ies), immune-incompetent states, the need for ICU management, and were associated with substantial mortality.

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Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcomes of Pasteurella multocida Infection

et al. 2015

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“…Upper respiratory tract infections caused by P. multocida include pharyngitis, sinusitis, otitis media, epiglottitis, and rarely Ludwig's angina [12]. Lower respiratory tract infections caused by the bacteria include tracheobronchitis, pneumonia, empyema, and abscess.…”

Section: Discussionmentioning

confidence: 99%

Multiorgan Failure and Refractory Lactic Acidosis due toPasteurella multocidaSepticemia in a Patient with No Animal Exposure

Pena

Santana

Lara

et al. 2018

Case Reports in Infectious Diseases

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Introduction Pasteurella multocida is a gram-negative coccobacillus pathogenic to animals. It can cause infection in humans by a bite, scratch, or lick from a cat or dog. P. multocida can cause a variety of infections in humans, including cellulitis, osteomyelitis, endocarditis, peritonitis, and septic shock. Case Presentation A 56-year-old male presented to our hospital with a 2-day history of fever, abdominal pain, nausea, and vomiting. He denied exposure to cats, dogs or other pets. He had severe respiratory distress requiring ventilator support, profound septic shock requiring multiple vasopressors, severe lactic acidosis, and renal failure requiring emergent hemodialysis. Blood cultures confirmed the presence of P. multocida. The patient subsequently died of cardiopulmonary arrest due to multiorgan failure with refractory shock. Conclusion P. multocida septicemia can lead to septic shock. Early identification of this organism may decrease mortality. Although our patient had no known cat or dog exposure, physicians should enquire about a history of animal exposure when a patient presents with an infection with no obvious cause.

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“…Epiglottitis is characterized by inflammation of the epiglottis and surrounding structures and classically presents with severe sore throat, dysphagia, and leukocytosis. 1 Although uncommon, it is a life-threatening disease that can cause acute airway obstruction. The most common etiology of epiglottitis is an infection by Streptococcus pneumonia , Staphylococcus aureus, or Haemophilus influenzae (type B, A, F, and nontypable), while other bacteria, viruses, and fungi constitute more rare forms.…”

Section: Introductionmentioning

confidence: 99%

“… 10 In humans, there are only eight reported cases of P. multocida epiglottitis in the literature since 1977. 1 , 2 , 4 – 9 All eight reports involve middle-aged adults, seven of whom were men. Three cases involved immunosuppressed patients.…”

Section: Introductionmentioning

confidence: 99%