Pasteurella multocida Epiglottitis

Moyko, Andrey; Ali, Nissa J.; Dubosh, Nicole M.; Wong, Matthew L.

doi:10.5811/cpcem.2016.11.32294

Cited by 8 publications

(10 citation statements)

References 18 publications

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“…Only nine other cases of epiglottitis in the literature have been attributed to P. multocida (Table 1). [2][3][4]6,[8][9][10][11][12] To our knowledge, this represents the 10th case. Infection in all but one of the 10 cases was related to animal exposure-primarily cats, but dogs have been implicated as well.…”

Section: Discussionmentioning

confidence: 73%

Acute epiglottitis due to Pasteurella multocida after contact with a feral cat

Sisco

Cahuayme-Zuniga

2019

Baylor University Medical Center Proceedings

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Pasteurella multocida is a bipolar staining gram-negative coccobacillus that resides in the nasopharynx of many animals, most notably felines. It is a common cause of soft tissue infections following animal bites but has rarely been reported to cause epiglottitis. Here we describe a case of epiglottitis and bacteremia due to P. multocida following exposure to a feral cat. The patient required emergent cricothyrotomy due to airway compromise. He was successfully treated with 14 days of beta-lactam therapy and achieved a full recovery.

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Section: Discussionmentioning

confidence: 73%

Acute epiglottitis due to Pasteurella multocida after contact with a feral cat

Sisco

Cahuayme-Zuniga

2019

Baylor University Medical Center Proceedings

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“…This result surpassed that of Khamesipour et al [ 24 ] from Iran, who recovered P. multocida from 11.4% of pneumonic cases and 4.4% of healthy cases. The isolation of P. multocida from cases of human epiglottitis was confirmed by Glickman and Klein [ 25 ] from the USA, who demonstrated its presence in adults without exposure to animals, and Moyko and Ali [ 26 ], who confirmed epiglottitis in a human who was exposed to animals. As the human samples were collected from animal owners and farm workers, this could suggest that exposure to animals can enhance infection transmission to humans.…”

Section: Discussionmentioning

confidence: 92%

“…The high resistance in the P. multocida isolates to cefotaxime contradicts the results of Elshemey et al [ 39 ] from Egypt, who confirmed that cefotaxime was the most effective antimicrobial against P. multocida , accompanying the foot and mouth disease virus SAT 2 FMD on bovine farms in Alexandria province, Egypt. Scarce data were found concerning the antimicrobial susceptibility profiles of P. multocida isolated from human epiglottitis, although Glickman and Klein [ 25 ] confirmed that an isolate from an infected 44-year-old human patient from the USA was susceptible to ceftriaxone, and Moyko and Ali [ 26 ] showed that an isolate from a 49-year-old female from the USA was susceptible to ampicillin–sulbactam.…”

Section: Discussionmentioning

confidence: 99%

Virulence Determinants and Antimicrobial Profiles of Pasteurella multocida Isolated from Cattle and Humans in Egypt

et al. 2021

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Pasteurella multocida is a Gram-negative bacterium that causes drastic infections in cattle and humans. In this study, 55 isolates were recovered from 115 nasal swabs from apparently healthy and diseased cattle and humans in Minufiya and Qalyubia, Egypt. These isolates were confirmed by kmt1 existence, and molecular classification of the capsular types showed that types B, D, and E represented 23/55 (41.8%), 21/55 (38.1%), and 11/55 (20.0%), respectively. The isolates were screened for five virulence genes with hgbA, hgbB, and ptfA detected in 28/55 (50.9%), 30/55 (54.5%), and 25/55 (45.5%), respectively. We detected 17 capsular and virulence gene combinations with a discriminatory power (DI) of 0.9286; the most prevalent profiles were dcbF type D and dcbF type D, hgbA, hgbB, and ptfA, which represented 8/55 (14.5%) each. These strains exhibited high ranges of multiple antimicrobial resistance indices; the lowest resistances were against chloramphenicol, ciprofloxacin, amoxicillin/clavulanic acid, and levofloxacin. The macrolide–lincosamide–streptogramin B methylase gene erm(Q), with erm(42) encoding MLSB monomethyltransferase, mph(E) encoding a macrolide efflux pump, and msr(E) encoding macrolide-inactivating phosphotransferase were present. The class 1 and 2 integrons and extended-spectrum β-lactamase genes intl1, intl2, blaCTX-M, blaCTX-M-1, and blaTEM were detected. It is obvious to state that co-occurrence of resistance genes resulted in multiple drug-resistant phenotypes. The identified isolates were virulent, genetically diverse, and resistant to antimicrobials, highlighting the potential risk to livestock and humans.

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“…Fewer than 20 cases of P. multocida epiglottitis have been reported in the literature; all of which occurred in middle-aged adults. 7,9 Epiglottitis due to P. multocida has previously been described in nonbite transmissions. 9 Pasteurella multocida can also manifest as bacteremia.…”

Section: Discussionmentioning

confidence: 99%

“…Epiglottitis is described as inflammation of the epiglottis and surrounding tissue. It is most commonly caused by group A β-hemolytic Streptococcus pneumoniae , Staphylococcus aureus , or Haemophilus influenzae (type B, A, F, and nontypable) 7,9 . It has been hypothesized that the mortality rate in adult epiglottitis is higher than that of children because adult epiglottitis is often not diagnosed in a timely manner 9 .…”

Section: Discussionmentioning

confidence: 99%