Parvovirus B19‐associated haemophagocytosis in Evans syndrome: aplastic crisis accompanied by severe thrombocytopenia

Uike, Naokuni; Miyamura, Tomoya; Obama, Kosuke; Takahira, Hiroyuki; Sato, Hiroyuki; Kozuru, Mitsuo

doi:10.1111/j.1365-2141.1993.tb03113.x

Cited by 34 publications

(20 citation statements)

References 12 publications

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“…Several case reports have indicated that B19 may cause variable degrees of thrombocytopenia [69,70] and idiopathic thrombocytopenic purpura [71]. B19 has infrequently been associated with other haematological manifestations, including transient erythroblastopenia of childhood [72], DiamondBlackfan anaemia [73] and haemophagocytic lymphohistiocytosis [74].…”

Section: Haematological Disordersmentioning

confidence: 97%

Neurological manifestations of human parvovirus B19 infection

Barah

Vallely

Cleator

et al. 2003

Reviews in Medical Virology

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Since its discovery, human parvovirus B19 has been linked with a broad spectrum of clinical syndromes. An aetiological role for the virus has been confirmed in erythema infectiosum, transient aplastic crisis, persistent infection manifesting as pure red cell aplasia in immunocompromised persons, non-immune hydrops fetalis and arthritis. Less commonly recognised, but receiving increasing attention recently, are the neurological manifestations, a variety of which have been described in patients with either clinically diagnosed or laboratory confirmed B19 infection. The purpose of this review is to summarise present knowledge of B19, its known and potential pathogenic mechanisms and its association with human diseases, particularly those with neurological manifestations. The outcome of the review supports an aetiological role of the virus in neurological disease. However, the pathogenesis remains unknown and elucidating this is a priority.

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Section: Haematological Disordersmentioning

confidence: 97%

Neurological manifestations of human parvovirus B19 infection

Barah

Vallely

Cleator

et al. 2003

Reviews in Medical Virology

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“…Deve-se prestar particular atenção nas infecções intrauterinas por parvovírus B19, pois estas podem levar à hidropsia e morte fetal, sendo responsáveis por cerca de 16 % dos casos de hidropsia fetal não imune 6 . Em pacientes portadores de hemoglobinopatias, como doença falciforme e talassemias, ou defeitos da membrana eritrocitária, como na esferocitose hereditária, a parvovirose aguda pode desencadear crises aplásticas 2,[7][8][9][10][11] . A associação entre infecções por parvovírus B19 e HIV-1, produzindo aplasia pura de glóbulos vermelhos, também já foi descrita 12 .…”

Section: Introductionunclassified

Transient pancytopenia induced by parvovirus B19 in a child with hereditary spherocytosis

Valera¹,

Cipolotti²,

Bernardes³

et al. 2000

J Pediatr (Rio J)

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ResumoObjetivo: Relatar a ocorrência de pancitopenia transitória, decorrente de infecção pelo parvovírus B19, em um paciente portador de anemia hemolítica hereditária e comentar a importância do diagnóstico desta infecção.Métodos: Relato de caso clínico acompanhado pelos autores, diagnosticado sorologicamente e pelo método da reação em cadeia da polimerase (PCR), e revisão da literatura.Resultados: Menino de 12 anos, portador de esferocitose hereditária, apresentando quadro infeccioso inespecífico seguido de pancitopenia grave, transitória, com diagnóstico de infecção por parvovírus B19.Conclusões: O diagnóstico da infecção por parvovírus B19 é de particular importância em hematologia, principalmente quando estão presentes algumas condições mórbidas, entre elas as anemias hemolíticas hereditárias, sendo o método de PCR útil por permitir rapidez e boa sensibilidade no diagnóstico específico desta patolog i a .J. pediatr. (Rio J.). 2000; 76(4): 323-326: pancitopenia, crise aplástica, anemias hemolíticas, esferocitose hereditária, parvovírus B19. AbstractObjective: To describe the occurrence of transient pancytopenia induced by parvovirus B19 infection in a patient with hereditary hemolytic anemia and to discuss the importance of the diagnosis of this pathology.Methods: Case report of a child whose diagnosis was made by polymerase chain reaction (PCR) and serology, and review of the literature.Clinical report: A twelve year-old male patient with hereditary spherocytosis, presenting non-specific symptoms of an infectious syndrome followed by severe and transient pancytopenia, whose diagnosis was a parvovirus B19 infection.Conclusion: The diagnosis of parvovirus infection has a particular importance in hematology, especially on some morbid conditions, among them the hereditary hemolytic anemias. PCR is useful because of its rapidness and sensitivity on the specific diagnosis of this disease. J. pediatr. (Rio J.). 2000; 76(4): 323-326: pancytopenia, aplastic crisis, hemolytic anemias, hereditary spherocytosis, parvovirus B19

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“…B19 infection has been detected in cases of hemophagocytosis syndrome among children and adults (145,191,280,286,308,340,352; Toyoshige and Takahashi et al, Letter, Int. J. Hematol.…”

Section: Infection In the Immunodeficient Hostmentioning

confidence: 99%

Human Parvovirus B19

2002

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Parvovirus B19 (B19) was discovered in 1974 and is the only member of the family Parvoviridae known to be pathogenic in humans. Despite the inability to propagate the virus in cell cultures, much has been learned about the pathophysiology of this virus, including the identification of the cellular receptor (P antigen), and the control of the virus by the immune system. B19 is widespread, and manifestations of infection vary with the immunologic and hematologic status of the host. In healthy immunocompetent individuals B19 is the cause of erythema infectiosum and, particularly in adults, acute symmetric polyarthropathy. Due to the tropism of B19 to erythroid progenitor cells, infection in individuals with an underlying hemolytic disorder causes transient aplastic crisis. In the immunocompromised host persistent B19 infection is manifested as pure red cell aplasia and chronic anemia. Likewise, the immature immune response of the fetus may render it susceptible to infection, leading to fetal death in utero, hydrops fetalis, or development of congenital anemia. B19 has also been suggested as the causative agent in a variety of clinical syndromes, but given the common nature, causality is often difficult to infer. Diagnosis is primarily based on detection of specific antibodies by enzyme-linked immunosorbent assay or detection of viral DNA by dot blot hybridization or PCR. Treatment of persistent infection with immunoglobulin reduces the viral load and results in a marked resolution of anemia. Vaccine phase I trials show promising results

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Parvovirus B19‐associated haemophagocytosis in Evans syndrome: aplastic crisis accompanied by severe thrombocytopenia

Cited by 34 publications

References 12 publications

Neurological manifestations of human parvovirus B19 infection

Neurological manifestations of human parvovirus B19 infection

Transient pancytopenia induced by parvovirus B19 in a child with hereditary spherocytosis

Human Parvovirus B19

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