Partnership on Rotational ViscoElastic Test Standardization (PROVETS): Evidence‐based guidelines on rotational viscoelastic assays in veterinary medicine

Goggs, Robert; Brainard, Benjamin M.; Laforcade, Armelle M. de; Flatland, Bente; Hanel, Rita M.; McMichael, Maureen; Wiinberg, Bo

doi:10.1111/vec.12144

Cited by 92 publications

(145 citation statements)

References 144 publications

(231 reference statements)

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“…A model‐based scoring system was developed in veterinary medicine, but the application of this scoring system was not possible in this study, because it used reference intervals for tests performed at 1 specific laboratory. Finally, no discard tube was used to collect the blood samples, unlike the recommended standard . It is possible that this method of blood collection led to preanalytical bias.…”

Section: Discussionmentioning

confidence: 99%

Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study

Barthélémy

Magnin

Pouzot‐Nevoret

et al. 2016

Veterinary Internal Medicne

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BackgroundLeptospirosis in dogs is occasionally associated with a hemorrhagic syndrome, the pathophysiology of which is not fully understood.Hypothesis/ObjectivesTo characterize hematologic, hemostatic, and thromboelastometric abnormalities in dogs with leptospirosis and to study their association with hemorrhagic diatheses and outcomes.AnimalsThirty‐five client‐owned dogs.MethodsA prospective observational single cohort study was conducted. Results from the CBC, coagulation tests (prothrombin, activated partial thromboplastin and thrombin times, fibrinogen, fibrin(ogen) degradation products, and D‐dimer concentrations), rotational thromboelastometry (TEM), signalment, hemorrhagic diatheses, occurrence of disseminated intravascular coagulation (DIC) at admission, and survival to discharge were recorded.ResultsThe most common hematologic and hemostatic abnormalities were anemia (30/35), thrombocytopenia (21/35), and hyperfibrinogenemia (15/35). Eight dogs were diagnosed with DIC. A normal TEM profile was found in 14 dogs, a hypercoagulable profile in 14 dogs, and a hypocoagulable profile in 7 dogs. The 8 dogs with hemorrhagic diatheses at admission had significantly decreased platelet counts (P = .037) and increased D‐dimer concentrations (P = .015) compared with other dogs. Dogs with a hypocoagulable profile exhibited more hemorrhagic diatheses compared with the dogs that had normal and hypercoagulable profiles (P = .049). The mortality rate was lower in dogs with a hypercoagulable profile than in those with a hypocoagulable profile (21% vs 57%; P = .043). Disseminated intravascular coagulation was not a significant prognostic factor.Conclusions and Clinical ImportanceThromboelastometric parameters were altered in dogs with both hypercoagulable and hypocoagulable profiles. A hypocoagulable profile was significantly correlated with hemorrhagic diathesis and higher mortality rate.

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Section: Discussionmentioning

confidence: 99%

Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study

Barthélémy

Magnin

Pouzot‐Nevoret

et al. 2016

Veterinary Internal Medicne

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“…The present study employed a nonhemorrhagic model, and hypercoagulability was not a finding, suggesting the results are still relevant. Finally, half of the TEM samples were run 60 minutes after collection, instead of the recommended 30 minutes . Studies have shown that samples appear to become more hypercoagulable with time .…”

Section: Discussionmentioning

confidence: 99%

The effect of 3 resuscitative fluid therapies on hemostasis as measured by rotational thromboelastometry in dogs

Seshia

Gaunt

Kidney

et al. 2018

Veterinary Clinical Pathol

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“…Practices using point‐of‐care viscoelastic devices will need to use established veterinary clinical pathology guidelines to determine reference intervals (Goggs et al . ).…”

Section: Laboratory Assessment Of Fibrinolysismentioning

confidence: 97%

A review of hyperfibrinolysis in cats and dogs

Birkbeck

Humm

Cortellini

2019

J of Small Animal Practice

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The fibrinolytic system is activated concurrently with coagulation; it regulates haemostasis and prevents thrombosis by restricting clot formation to the area of vascular injury and dismantling the clot as healing occurs. Dysregulation of the fibrinolytic system, which results in hyperfibrinolysis, may manifest as clinically important haemorrhage. Hyperfibrinolysis occurs in cats and dogs secondary to a variety of congenital and acquired disorders. Acquired disorders associated with hyperfibrinolysis, such as trauma, cavitary effusions, liver disease and Angiostrongylus vasorum infection, are commonly encountered in primary care practice. In addition, delayed haemorrhage reported in greyhounds following trauma and routine surgical procedures has been attributed to a hyperfibrinolytic disorder, although this has yet to be characterised. The diagnosis of hyperfibrinolysis is challenging and, until recently, has relied on techniques that are not readily available outside referral hospitals. With the recent development of point‐of‐care viscoelastic techniques, assessment of fibrinolysis is now possible in referral practice. This will provide the opportunity to target haemorrhage due to hyperfibrinolysis with antifibrinolytic drugs and thereby reduce associated morbidity and mortality. The fibrinolytic system and the conditions associated with increased fibrinolytic activity in cats and dogs are the focus of this review article. In addition, laboratory and point‐of‐care techniques for assessing hyperfibrinolysis and antifibrinolytic treatment for patients with haemorrhage are reviewed.

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Partnership on Rotational ViscoElastic Test Standardization (PROVETS): Evidence‐based guidelines on rotational viscoelastic assays in veterinary medicine

Cited by 92 publications

References 144 publications

Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study

Hemorrhagic, Hemostatic, and Thromboelastometric Disorders in 35 Dogs with a Clinical Diagnosis of Leptospirosis: A Prospective Study

The effect of 3 resuscitative fluid therapies on hemostasis as measured by rotational thromboelastometry in dogs

A review of hyperfibrinolysis in cats and dogs

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