The effect of 3 resuscitative fluid therapies on hemostasis as measured by rotational thromboelastometry in dogs

Seshia, Sunita; Gaunt, M. Casey; Kidney, Beverly A.; Jackson, Marion L.

doi:10.1111/vcp.12573

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Changes reported were not associated with clinical signs, but the population included healthy dogs, and identification of bleeding tendency was not the aim of the study. 12,41,42 In the HS-treated group, several ROTEM parameters were different between T0 and T1, with a tendency toward hypocoagulability, and a decrease in MCE PLT was indicative of reduced platelet contribution to clot contraction/elasticity. Although no difference was reported at T1 for the MCE PLT between the 2 groups, further studies with an increase in sample size or with different amounts of solutions administered could help to clarify this result.…”

Section: Discussionmentioning

confidence: 97%

“…Similar results on the standard coagulation profile were observed by Seshia et al after administration of 5 mL/kg of HS over 15 minutes and 20 mL/kg of HES over 30 minutes in healthy dogs, making it more likely that these changes were due to HS administration and not exclusive to our population. 42 After HS bolus administration, sodium and chloride were increased, to consumption of clotting factors and platelets caused by DIC. 31,33 One abstract published to date has described the use of a viscoelastic technique (TEG) in dogs with GDV, reporting that dogs with baseline TEG values outside the reference range had higher mortality than dogs without abnormalities.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of hemostasis in dogs with gastric‐dilation‐volvulus, during resuscitation with hydroxyethyl starch (130/0.4) or hypertonic saline (7.5%)

Borrelli

Giunti

Calipa

et al. 2021

J Vet Emergen Crit Care

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Objective: To compare the impact of an IV bolus of hydroxyethyl starch 130/0.4 (HES) or hypertonic saline 7.5% (HS) on hemostasis in dogs resuscitated for gastric-dilationvolvulus (GDV).Design: Open-label, parallel-group randomized clinical trial. Animals: Twenty-three client-owned dogs.Interventions: Dogs affected by GDV and shock were randomly assigned to receive HES at 10 mL/kg or HS at 4 mL/kg every 15 minutes. Blood samples were collected for blood gas analysis, PCV, total plasma protein, albumin, standard coagulation profile, and thromboelastometry (ROTEM) at baseline (T0) and at the end of bolus (T1). To assess the differences between the 2 groups at T1, Student's t-test or Wilcoxon ranksum test was used. To evaluate the differences between T0 and T1, ANOVA for paired data or Wilcoxon matched-pairs signed-ranks test was used. P < 0.05 was considered significant. Measurement and main results:Hemostasis was evaluated by means of prothrombin time, activated partial thromboplastin time, fibrinogen, and ROTEM. The study included 13 dogs in the HES group and 10 dogs in the HS group. Differences were found between groups at T1: increase in clotting time (P = 0.018) and decrease in fibrinogen level (P = 0.021) in the HS-treated group.Between T0 and T1, there were differences for the HES group: increase in clot formation time (P = 0.046), decrease in maximum clot firmness (P = 0.002) in ex-TEM profile, and decrease in maximum clot firmness (P = 0.0117) in fib-TEM profile. Between T0 and T1, the following differences were noted for the HS group: increase in clotting time (P = 0.048) and clot formation time (P = 0.0019), decrease in maximum clot firmness

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Assessment of hemostasis in dogs with gastric‐dilation‐volvulus, during resuscitation with hydroxyethyl starch (130/0.4) or hypertonic saline (7.5%)

Borrelli

Giunti

Calipa

et al. 2021

J Vet Emergen Crit Care

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“…These findings are in contrast to the studies by Bochsen, McMichael, Smith, Nagler and McMichael. An in vivo study that assessed the effect of clinically relevant doses of resuscitative fluids in dogs, using TEM, found that maximum clot firmness decreased after treatment with all fluid types, possibly the result of a dilutional effect on platelets and fibrinogen (Seshia et al 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Haemostatic changes associated with fluid resuscitation in canine parvoviral enteritis

Whitehead

Goddard

Botha

et al. 2020

Journal of the South African Veterinary Association

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The haemostatic status of dogs with canine parvovirus (CPV) enteritis, within 24 h of admission after initial fluid administration, has been described previously, but the haemostatic status at admission and after standard fluid resuscitation, as well as after initial fluid redistribution, has not been investigated previously. The objective of this study was to characterise the haemostatic status at admission and describe the effect of crystalloid fluid resuscitation on haemostatic variables in dogs with CPV enteritis. Twenty-seven client-owned, hospitalised dogs with confirmed natural CPV infection and 15 healthy age-matched controls were included in a prospective, observational clinical study. The volume of resuscitation fluid, haematocrit (HCT), platelet count, thromboelastography (TEG) variables, antithrombin (AT) activity, fibrinogen- and C-reactive protein (CRP) concentrations were measured in all dogs at admission, after fluid resuscitation and, in 10 dogs, after receiving an additional 3 hours of maintenance-rate crystalloid fluids. For the CPV group at admission, the median TEG reaction time (R) and maximum amplitude (MA) or clot strength, as well as the median HCT, fibrinogen and CRP concentrations, were significantly increased compared to the controls. After fluid resuscitation, median R was significantly shorter, MA significantly increased and HCT and AT activity significantly decreased compared to admission values. The haemostatic variables remained unchanged after 3 h of maintenance-rate crystalloid therapy. The increased clot strength present in dogs with CPV enteritis at admission was exacerbated after fluid resuscitation and persisted for hours after large-volume crystalloid fluid administration.

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Examining the Effect of Hypertonic Saline Administered for Reduction of Intracranial Hypertension on Coagulation

Coleman

Moore

Silliman

et al. 2020

Journal of the American College of Surgeons

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The effect of 3 resuscitative fluid therapies on hemostasis as measured by rotational thromboelastometry in dogs

Cited by 3 publications

References 29 publications

Assessment of hemostasis in dogs with gastric‐dilation‐volvulus, during resuscitation with hydroxyethyl starch (130/0.4) or hypertonic saline (7.5%)

Assessment of hemostasis in dogs with gastric‐dilation‐volvulus, during resuscitation with hydroxyethyl starch (130/0.4) or hypertonic saline (7.5%)

Haemostatic changes associated with fluid resuscitation in canine parvoviral enteritis

Examining the Effect of Hypertonic Saline Administered for Reduction of Intracranial Hypertension on Coagulation

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