Participation of baroreceptor reflexes in blood pressure and sympathetic nerve responses to a synthetic human atrial natriuretic peptide in anesthetized dogs

Atrial Natriuretic Peptide Has Dose‐Dependent, Autonomically Mediated Effects on Atrial Refractoriness and Repolarization in Anesthetized Dogs

“…ANP also acts directly at the cellular level to alter cardiac electrophysiology inhibiting L‐type Ca 2+ channels and reducing cytosolic Ca 2+ concentration in atrial and ventricular cells 1,2,6–9 . At the organ and whole animal level, ANP has dose‐dependent, modulating effects on the autonomic nervous system 2,10–20 . These and other observations suggest that ANP may alter electrophysiological properties of the in vivo heart and possibly have a role in arrhythmogenesis.…”

Effects of atrial natriuretic factor on baroreceptor reflexes.

“…Other studies have reported increased sympathetic nerve activity during intravenous infusion of ANF in animals with intact baroreceptors. 5 However, the latter results do not necessarily contradict the suggestion made by Thoren et al 2 and Imaizumi et al 3 The reflex changes in sympathetic nerve activity in vivo are a function of the competing influences of altered reflex control by ANF and hemodynamic changes.…”

Atrial Natriuretic Peptides in Brain Nuclei of Rats with Inherited Diabetes insipidus (Brattleboro Rats)

“…In addition to very high numbers of ANF receptors, it contains also very high concentrations of A II receptors and this organ has been shown to be the main brain target site for circulating A II [28,43]. The presence of ANF receptors in the SFO sug gests that this structure could mediate some of the postulated central actions of the circulating peptide, such as inhibition of thirst [I, 26,32], inhibition of vasopressin release [14], inhibi tion of salt appetite [7[, diuresis [15] and a fall in blood pres sure [17]. Since these actions oppose those of A II, a local antagonism between these two peptides was postulated to exist in the SFO [41].…”