Atrial Natriuretic Peptides in Brain Nuclei of Rats with Inherited Diabetes insipidus (Brattleboro Rats)

Bahner, Udo; Geiger, Helmut; Palkóvits, M.; Ganten, Detlev; Michel, Joachim; Heidland, A.

doi:10.1159/000125417

Cited by 13 publications

(7 citation statements)

References 48 publications

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“…We have previously characterized the role of the central ANP system in models of experimental hypertension and disturbances in electrolyte and fluid homeostasis. In these experiments very specific changes were found in the ANP system (16)(17)(18)(19). Thereby, an antagonism between Ang II and ANP seemed to be of special interest.…”

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confidence: 74%

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Angiotensin II-Induced Hypertension: Effects on Central and Peripheral Atrial Natriuretic Peptide.

et al. 1995

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Angiotensin (Ang) II and atrial natriuretic peptide (ANP) have opposing effects on blood pressure, sympathetic activity, vasopressin and ACTH secretion, salt appetite, and drinking. We observed their interaction by infusing Ang II (7.2 nmol/h) into the peritoneum (i.p.) or into the lateral ventricle (i.c.v.) of rats with osmotic minipumps for seven days. At sacrifice, rats receiving Ang II-i.c.v. had a systolic blood pressure of 184 +/- 3 (SEM) mmHg, those receiving Ang II-i.p. had 159 +/- 5 mmHg (p < 0.05), while controls had 109 +/- 2 and 110 +/- 2 mmHg, respectively (p < 0.05). Drinking and urine volume increased similarly in rats receiving Ang II by either route, while Uosm decreased. Renin (PRA) values were lower (p < 0.05) in rats receiving Ang II-i.c.v. (0.7 +/- 0.2 ng Ang l/ml/h) or Ang II-i.p. (0.9 +/- 0.2) than in the respective controls (2.3 +/- 0.7 and 2.0 +/- 0.3). Plasma ANP values with Ang II-i.c.v. (18 +/- 1.6 pg/ml) or with Ang II-i.p. (49 +/- 6) were also lower (p < 0.05) than respective controls (89 +/- 12, 76 +/- 4). Vasopressin (AVP) concentrations in the plasma were not influenced by the regimens. In the brain, the ANP contents in areas of the so-called AV3V-region (organum vasculosum laminae terminalis, preoptic periventricular nucleus, medial preoptic nucleus) were similarly and significantly reduced by both Ang II-i.c.v. and Ang II-i.p.. ANP values were also reduced in the median eminence by both types of Ang II-treatment, while ANP concentrations in the supraoptic nucleus were increased. The data show that Ang II infusions producing a chronic rise in blood pressure exert similar effects on drinking behavior, PRA, and ANP concentrations in blood and brain. The AV3V area may be pivotal to both models.

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confidence: 74%

“…In a pilot study we tested different doses of exogenous Ang II. For this experiment we selected a dose of 7.2 nmol/h, because this amount of Ang II yielded the same hypertensive effect as in our former experiments (16)(17)(18)(19). The dose employed was also comparable to the 6 ,uglh used by Bruner and Fink (6).…”

Section: Animal Models and Proceduresmentioning

confidence: 99%

Angiotensin II-Induced Hypertension: Effects on Central and Peripheral Atrial Natriuretic Peptide.

et al. 1995

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“…Two systems are involved in the secretion of ANP: peripheral ANP (heart and plasma) and central ANP (paraventricular, periventricular, arcuate, and pre-optical-medial nuclei and other sites) (6). Despite the blood-brain barrier, these systems communicate through the circumventricular organs, the organum vasculosum lamina terminalis and the organum subfornicalis (7)(8)(9). They are connected by neuronal synapses (9)(10)(11)(12)(13)(14), or by discharge of peptides such as vasopressin (15), endothelin (11) and oxytocin (16) from the hypothalamus.…”

Section: Mha Oliveira Et Almentioning

confidence: 99%

Atrial natriuretic peptide and feeding activity patterns in rats

Oliveira¹,

Antunes‐Rodrigues²,

Gutkowska³

et al. 1997

Braz J Med Biol Res

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This review presents historical data about atrial natriuretic peptide (ANP) from its discovery as an atrial natriuretic factor (ANF) to its role as an atrial natriuretic hormone (ANH). As a hormone, ANP can interact with the hypothalamic-pituitary-adrenal axis (HPA-A) and is related to feeding activity patterns in the rat. Food restriction proved to be an interesting model to investigate this relationship. The role of ANP must be understood within a context of peripheral and central interactions involving different peptides and pathways.

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“…and of these, the central actions of ANP have been studied to the greatest extent, by far. ANP in the preoptic area and hypothalamus may be involved with neuroendocrine (20, 21, 23, 30, 31 1, cardiovascular (32,33) and/or fluid balance (19,22,(34)(35)(36)(37)(38)(39) regulation. Thus, estrogen may be capable of regulating these functions through estrogen-receptive NP-ir neurons in the preoptic region.…”

Section: Discussionmentioning

confidence: 99%

Colocalization of Natriuretic Peptide and Estrogen Receptor Immunoreactivities in Preoptic Nuclei in the Female Rat

Watson

Hutchinson

Langub

et al. 1994

J Neuroendocrinology

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Estrogen IS known to play an important role in regulating reproductive function in female rats through actions exerted at the preoptic area, a part of the brain that is markedly sexually dimorphic and which contains abundant estrogen receptors. A critical question to our understanding of estrogen's action on the brain is to identify the types of neurons that contain estrogen receptors (ER). Previous studies have shown that atrial natriuretic peptide (ANP) is in abundance in the preoptic area, and that ANP and other natriuretic peptides are capable of regulating gonadotropin secretion. In an effort to determine whether ERs are present in natriuretic peptide-immunoreactive (NP-ir) neurons in the preoptic area of the rat, double label immunocytochemistry was performed. Since ER-ir, as demonstrated with antibody H222 is known to be localized predominantly in cell nuciei, while NP-ir is present in the cytoplasm, single cells can be double labeled. Diaminobenzidine tetrahydrochloride was used for localization of NP-ir neurons, while nickel-enhanced diaminobenzidine tetrahydrochloride was used for localization of ER-ir. The results revealed that many nuclei throughout the preoptic area contained neurons that were ER-ir or NP-ir and that a substantial number were double labeled. Cell counts in selected preoptic nuclei and components, including the anteroventral periventricular nucleus, periventricular preoptic nucleus, medial part of the medial preoptic nucleus, and central part of the medial preoptic nucleus revealed that 13.6%, 11.1 %, 13.5%, and 24.4%, respectively, of the NP-ir neurons in these nuclei also contained ER-ir. Collectively, a totai of 14.9% of the NP-ir neurons in these nuclei also contained ER-ir. These results support the hypothesis that estrogen may regulate the activity of NP-ir cells in the preoptic area and thereby may be capable of altering functions associated with NPs in this region of the brain, including not only regulation of gonadotropin secretion, but also control of blood pressure and fluid balance.The preoptic area contains a number of distinct sexually dimorphic nuclei, including the anteroventral periventricular nucleus (AVPv) (1, 2), (also referred to as the anterior component of the medial preoptic nucleus) (3), periventricular preoptic nucleus (PVp) (1, 4), and the medial preoptic nucleus (MPN) (4, 5). These nuclei are characterized by the presence of abundant estrogen receptor (ER)-containing neurons (6-8) and many different neurotransmitters and neuroactive peptides have been localized in neurons within these nuclei (2,4). Natriuretic peptides (NP), including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP) have been described in the preoptic area and hypothalamus (9-16) and these compounds are biologically active in brain ( 17-27). ANP, BNP, and CNP share extensive sequence homology, but are coded for by separate genes (15,28,29). Using an antiserum that recognized the ANP precursor, Saper and colleagues ( 10) identif...

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Atrial Natriuretic Peptides in Brain Nuclei of Rats with Inherited Diabetes insipidus (Brattleboro Rats)

Cited by 13 publications

References 48 publications

Angiotensin II-Induced Hypertension: Effects on Central and Peripheral Atrial Natriuretic Peptide.

Angiotensin II-Induced Hypertension: Effects on Central and Peripheral Atrial Natriuretic Peptide.

Atrial natriuretic peptide and feeding activity patterns in rats

Colocalization of Natriuretic Peptide and Estrogen Receptor Immunoreactivities in Preoptic Nuclei in the Female Rat

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