Partial characterization, origin and turnover of glycoproteins of the rabbit vitreous body

Haddad, Antônio; Laicine, Eduardo Miguel; Almeida, Jorge Rady de; Costa, Moacyr Lobo da

doi:10.1016/0014-4835(90)90065-3

Cited by 27 publications

(12 citation statements)

References 22 publications

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“…Some of these are derived from serum, such as serum albumin, but others are synthesised within the eye and appear to be largely derived from the ciliary body. 43 Transferrin, a major glycoprotein present in the vitreous, was recently shown to be synthesised by the ciliary body epithelium. 44 …”

Section: Non-collagenous Vitreous Componentsmentioning

confidence: 99%

The role of the posterior ciliary body in the biosynthesis of vitreous humour

Bishop

Takanosu

Goff

et al. 2002

Eye

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Recently, several groups have published new information regarding the origins and structure of the vitreous humour, and the inner limiting lamina (ILL) of the retina. This short article provides an overview of this new information. It is proposed that vitreous proteins are derived from several different cell types with the posterior half of the non-pigmented ciliary epithelium being prominent in the expression of several connective tissue macromolecules. In addition, some basement membrane macromolecules are also expressed by the ciliary body and may subsequently be assembled on the surface of the Mü ller cells to form the ILL. New data suggest that the posterior half of the non-pigmented ciliary epithelium has substantial secretory activity and is likely to play a pivotal role in eye development.

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Section: Non-collagenous Vitreous Componentsmentioning

confidence: 99%

The role of the posterior ciliary body in the biosynthesis of vitreous humour

Bishop

Takanosu

Goff

et al. 2002

Eye

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“…It is the largest structure of the eye and consists of 98% to 99% water and of just 0.1% macromolecules, such as glycosaminoglycans (such as hyaluronan), 1 proteoglycans, 2,3 glycoproteins 4 (such as opticin 5,6 ), collagens, [7][8][9][10][11][12][13][14][15] and noncollagenous structural proteins 4,5,16,17 (e.g., fibrillin 5 ). The most important macromolecules are the collagens, which form a network of heterotypic fibrils (types II, V/XI, and IX) and presumably maintain the gel structure.…”

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confidence: 99%

Collagen Distribution in the Human Vitreoretinal Interface

Ponsioen

Luyn

Worp

et al. 2008

Invest. Ophthalmol. Vis. Sci.

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Staining patterns of collagen types I to V, IX, XI, and XVIII confirmed previous observations. Important new findings include the presence of type VI in the ILM and type VII in several layers of the retina. Both collagens can anchor matrix components, and type VI could be involved in vitreoretinal attachment. Furthermore, the presence of collagen mRNA in human retinectomy samples may be an indication of postnatal collagen production by retinal cells.

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“…20 Ci mmol −" ) at a dose of 20 µCi per eye and killed in groups of two at each of the following time intervals : 4 hr, and 1, 2 and 7 days after injection. The intravitreal injections (Haddad et al, 1990) were performed while the rabbits were under general anesthesia. Sections of the eyes were processed for autoradiography using Amersham photographic emulsion, type LM1.…”

Section: Autoradiographymentioning

confidence: 99%