The role of the posterior ciliary body in the biosynthesis of vitreous humour

Bishop, Paul N.; Takanosu, Masamine; Goff, Magali Le; Mayne, Richard

doi:10.1038/sj.eye.6700199

Cited by 81 publications

(46 citation statements)

References 49 publications

(52 reference statements)

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“…The overall structure of cochlin resembles two other proteins, vitrin and akhirin, that also contain the FCH domain followed by two vWFA domains and that have been localized to the vertebrate eye (Mayne et al, 1999;Ahsan et al, 2005). Vitrin was originally identified in vitreous of bovine eyes and it is expressed in lens (Mayne et al, 1999;Bishop et al, 2002). Akhirin is expressed in the ciliary marginal zone, lens epithelium as well as in the retinal pigment epithelial layer (Ahsan et al, 2005).…”

Section: Previous Cochlin Structure-function Studiesmentioning

confidence: 99%

Cochlin and glaucoma: A mini-review

2005

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Primary open angle glaucoma (POAG) is a leading cause of late onset, progressive, irreversible blindness and, although its etiology is poorly understood, elevated intraocular pressure (IOP) often appears to be a contributory factor. Proteomic and Western analyses of trabecular meshwork (TM) from patients with POAG and age-matched controls originally implicated cochlin as possibly contributing to glaucoma pathogenesis. Cochlin deposits were subsequently detected in glaucomatous but not in control TM and older glaucomatous TM was found to contain higher levels of cochlin and significantly lower amounts of collagen type II. More recently, similar results were reported in DBA/2J mice, which at older ages develop elevated IOP, retinal ganglion cell degeneration, and optic nerve damage. Notably, cochlin was absent in TM from C57BL/6J, CD1, and BALBc/ByJ mice, which do not exhibit elevated IOP or glaucoma. Cochlin was found in the TM of very young DBA/2J mice, prior to elevated IOP, suggesting that over time the protein may contribute to the events leading to increased IOP and optic nerve damage. Here we review these findings and describe how future studies in DBA/2J mice can help resolve whether cochlin plays a causal role in mechanisms of POAG and elevated IOP.

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Section: Previous Cochlin Structure-function Studiesmentioning

confidence: 99%

Cochlin and glaucoma: A mini-review

2005

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“…7), suggesting that the small size of bel eyes at later ages is not due to proliferation defects but is due to the failure of the posterior compartment to form. The posterior compartment is filled with vitreous humor, which is produced by cells of the CMZ (reviewed by Bishop et al, 2002). CMZ cells appear to differentiate appropriately based on ␣-collagen expression in bel mutants (data not shown); however, this region of the eye is clearly disrupted, as evidenced by the gap between the PE and the lens, and by the presence of ectopic lens proteins (Fig.…”

Section: Lhx2 and Eye Developmentmentioning

confidence: 99%

belladonna/(lhx2)is required for neural patterning and midline axon guidance in the zebrafish forebrain

et al. 2006

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Some of the earliest axon pathways to form in the vertebrate forebrain are established as commissural and retinal axons cross the midline of the diencephalon and telencephalon. To better understand axon guidance in the forebrain, we characterized the zebrafish belladonna (bel)mutation, which disrupts commissural and retinal axon guidance in the forebrain. Using a positional cloning strategy, we determined that the bel locus encodes zebrafish Lhx2, a lim-homeodomain transcription factor expressed in the brain, eye and fin buds. We show that bel(lhx2) function is required for patterning in the ventral forebrain and eye, and that loss of bel function leads to alterations in regulatory gene expression, perturbations in axon guidance factors, and the absence of an optic chiasm and forebrain commissures. Our analysis reveals new roles for lhx2 in midline axon guidance, forebrain patterning and eye morphogenesis.

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“…The ciliary body is a structure in the eye, which is located immediately behind the iris and in front of the choroids. It secretes the aqueous humor, and is the source of the zonules that support the lens (Bishop et al, 2002). The ciliary body also contains the ciliary muscle, which changes the shape of the lens when the eye focuses on an object.…”

Section: Heterotypic Adhesion In the Ciliary Epitheliummentioning

confidence: 99%

The role of nectins in different types of cell–cell adhesion

Rikitake

Mandai

Takai

2012

Journal of Cell Science

132

115

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SummaryMammalian tissues and organs are composed of different types of cells that adhere to each other homotypically (i.e. interactions between cells of the same cell type) or heterotypically (i.e. interactions between different cell types), forming a variety of cellular patterns, including mosaic patterns. At least three types of cell-cell adhesion have been observed: symmetric homotypic, asymmetric homotypic and heterotypic cell adhesions. Cadherins and nectins, which are known cell-cell adhesion molecules, mediate these cell adhesions. Cadherins comprise a family of more than 100 members, but they are primarily involved in homophilic trans-interactions (i.e. interactions between the same cadherin members) between opposing cells. By contrast, the nectin family comprises only four members, and these proteins form both homophilic and heterophilic trans-interactions (i.e. interactions between the same and different nectin members on opposing cells). In addition, heterophilic trans-interactions between nectins are much stronger than homophilic trans-interactions. Because of these unique properties, nectins have crucial roles in asymmetric homotypic cell-cell adhesion at neuronal synapses and in various types of heterotypic cell-cell adhesions. We summarize recent progress in our understanding of the biology of nectins and discuss their roles in heterotypic cell-cell adhesions, whose formation cannot be solely explained by the action of cadherins.

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The role of the posterior ciliary body in the biosynthesis of vitreous humour

Cited by 81 publications

References 49 publications

Cochlin and glaucoma: A mini-review

Cochlin and glaucoma: A mini-review

belladonna/(lhx2)is required for neural patterning and midline axon guidance in the zebrafish forebrain

The role of nectins in different types of cell–cell adhesion

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