Parkinson's Disease Mortality in Italy, 1951 Through 1987

Chiò, Adriano; Magnani, Corrado; Tolardo, Gianpiero; Schiffer, Davide

doi:10.1001/archneur.1993.00540020027012

Cited by 15 publications

(7 citation statements)

References 27 publications

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“…The increased mortality rate in the 1980’s was a direct result of changes in the coding practices [9,12]. However, despite these problems, these studies gave some indication that PD mortality was declining over time for younger age‐groups, but increasing for older age‐groups [12–14]. This is in contrast to the results presented here on a more modern dataset, which showed falls for all ages, but larger falls in mortality for the older age groups.…”

Section: Discussioncontrasting

confidence: 57%

“…It is also possible that the decrease in PD mortality is simply an artifact and is in fact because of more accurate diagnosis, especially in the elderly population. Idiopathic PD can be confused with other common causes of parkinsonism, such as a multiple infarct state, multiple system degenerations, progressive supranuclear palsy, Alzheimer’s disease or cerebrovascular pathology which in the past would have lead to over – diagnosis of idiopathic PD [12–15]. Over the 15‐year‐period of this study it is possible that the accuracy of diagnosing idiopathic PD has slowly improved, resulting in fewer patients with Parkinson‐like symptoms being diagnosed with idiopathic PD.…”

Section: Discussionmentioning

confidence: 99%

“…We have shown that coding changes strongly affected the likelihood of PD being selected as the underlying cause of death. Past studies of PD mortality in England and Wales (1921–1989) and Italy (1951–1987) have tried to deduce trends solely from the underlying cause of death but it is clear that interpreting these trends is problematic [12–14]. For example, a previous analysis of trends of mortality from PD as the underlying cause of death in England and Wales showed that rates fell between 1960 and 1980, but increased between 1980 and 1989 [12].…”

Section: Discussionmentioning

confidence: 99%

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Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006

Mylne

Griffiths

Rooney

et al. 2009

Euro J of Neurology

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Parkinson's disease mortality rates in England and Wales are decreasing, especially for men and for older age-groups. Because of data limitations we are unable to ascertain whether the decrease of PD recorded on death certificates is because of a reduction in PD incidence, or to improved survival for PD patients resulting from advancements in PD treatments or to improvements in general medical care. The dramatic increase in PD as the underlying cause of death following ICD revision in 2001 demonstrates the dangers of using underlying cause of death to investigate mortality trends without being aware of the potential for artifacts.

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Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006

Mylne

Griffiths

Rooney

et al. 2009

Euro J of Neurology

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“…In most parkinsonian studies men outnumber women by 1.4–3 :11 6 10 13 16 19 26 32 33 35 yet since the 1967 report of Hoehn and Yahr19 there have been repeated reports of increased mortality in women compared with men with Parkinson’s disease 1316 32 50 Some find no difference or find a lower mortality in women 8…”

Section: Discussionmentioning

confidence: 99%

The Sydney multicentre study of Parkinson's disease: progression and mortality at 10 years

Hely

Morris

Traficante

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

328

275

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Objectives-To report on a 10 year follow up of patients with idiopathic Parkinson's disease, particularly with respect to mortality and the eVect of early treatment with bromocriptine. Methods-The patients are from the 149 new patients recruited for a double blind, randomised study of low dose levodopacarbidopa versus low dose bromocriptine. Patients were examined neurologically at least yearly. Neuropsychological examinations were performed at 0, 3, 5, and 10 years. Mortality and cause of death in these patients were compared with the Australian population using standardised mortality ratios (SMRs). Mortality and disease progression were compared by sex and treatment group. Predictors of death within 10 years, nursing home admission, and progression in Columbia score of >20 points were examined by logistic regression analysis. Results-Thirteen patients were excluded as having atypical Parkinsonism and six were lost to follow up. All available patients have been followed up for 10 years. Fifty patients (38%) were dead by 10 years and 63 by the last follow up. The SMR was 1.58 for all patients (p<0.001). There was no significant diVerence in SMRs between the sexes. The mean duration of disease until death was 9.1 years. Parkinson's disease was thought to have contributed substantially to the death of 30 patients. The most common cause of death was pneumonia. Women progressed at a similar rate to men until 8 years, when the severity of their disease as measured by Hoehn and Yahr stage became greater (p<0.05). Older age of onset correlated with increased risk of death but the SMR was increased even in those aged <70 years (SMR 1.80, p=0.03). Early use of bromocriptine did not reduce mortality or slow progression of disease. One quarter of all patients had been admitted to nursing homes by 10 years. Only four patients were still employed. Conclusions-Mortality in Parkinson's disease remains increased despite low dose levodopa-carbidopa therapy and no additional benefit was gained from early use of bromocriptine. Duration of disease was similar to that in the era before levodopa. (J Neurol Neurosurg Psychiatry 1999;67:300-307)

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“…Previous studies have found that mortality from some mental and neurological diseases has risen, while mortality from other causes in this group has remained stable or has even declined. Over the past decades, many high-income countries have witnessed a rise of age-adjusted mortality from dementia [8]–[11] and motor neuron diseases [12]–[14], but reports on trends in mortality from psychoactive substance use [15]–[18], Parkinson’s disease [14, 19, 20], multiple sclerosis [14, 21, 22] and epilepsy [14, 23, 24] have been less consistent. Mortality from infectious diseases of the central nervous system, such as meningitis, has declined [10].…”

Section: Introductionmentioning

confidence: 99%

The rise of mortality from mental and neurological diseases in Europe, 1979–2009: observational study

2014

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BackgroundWe studied recent trends in mortality from seven mental and neurological conditions and their determinants in 41 European countries.MethodsAge-standardized mortality rates were analysed using standard methods of descriptive epidemiology, and were related to cultural, economic and health care indicators using regression analysis.ResultsRising mortality from mental and neurological conditions is seen in most European countries, and is mainly due to rising mortality from dementias. Mortality from psychoactive substance use and Parkinson’s disease has also risen in several countries. Mortality from dementias has risen particularly strongly in Finland, Iceland, Malta, Netherlands, Spain, Sweden and the United Kingdom, and is positively associated with self-expression values, average income, health care expenditure and life expectancy, but only the first has an independent effect.ConclusionsAlthough trends in mortality from dementias have probably been affected by changes in cause-of-death classification, the high level of mortality from these conditions in a number of vanguard countries suggests that it is now among the most frequent causes of death in high-income countries. Recognition of dementias as a cause of death, and/or refraining from life-saving treatment for patients with dementia, appear to be strongly dependent on cultural values.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2458-14-840) contains supplementary material, which is available to authorized users.

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Parkinson's Disease Mortality in Italy, 1951 Through 1987

Cited by 15 publications

References 27 publications

Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006

Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006

The Sydney multicentre study of Parkinson's disease: progression and mortality at 10 years

The rise of mortality from mental and neurological diseases in Europe, 1979–2009: observational study

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