Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006

Mylne, Adrian; Griffiths, Clare; Rooney, Catherine; Doyle, Pat

doi:10.1111/j.1468-1331.2009.02715.x

Cited by 30 publications

(25 citation statements)

References 17 publications

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“…16,17 However, given the effect of UCD on place of death, using any mention may mask inequalities in place of death, particularly in PD and MS where a large proportion of patients die with UCD other than their neurological condition. In contrast, using any mention may be particularly appropriate for studies investigating the population burden of these diseases or the effects of co-morbidity on place of death.…”

Section: Discussionmentioning

confidence: 99%

“…15 Specifically, internationally implemented changes to coding rules (in particular Rule 3) with the introduction of the International Classification of Diseases, 10th Revision (ICD-10) in 2001 led to a reduction in the number of deaths assigned to bronchopneumonia as UCD and a reciprocal increase in the number of deaths assigned to chronic conditions such as neurological diseases. 16,17 Therefore, the aims of this study were to use national mortality statistics to explore the relationship between UCD and place of death in PD, MS and MND and the impact of coding rule changes on analysis of place of death.…”

Section: Introductionmentioning

confidence: 99%

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Place of death, and its relation with underlying cause of death, in Parkinson’s disease, motor neurone disease, and multiple sclerosis: A population-based study

Sleeman

Verne³

et al. 2013

Palliat Med

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Background:Little is known about place of death in chronic neurological diseases. Mortality statistics are ideal for examining trends in place of death, but analyses are limited by coding rule changes. Aim: To examine the relationship between place of death and underlying cause of death in Parkinson's disease, multiple sclerosis and motor neurone disease and the impact of coding rule changes on analysis of place of death. Design: Population-based study. Proportion ratios for death in hospice, home, care home and hospital were calculated according to underlying cause of death, using multivariable Poisson regression. Participants: Deaths in England (1993 with any mention of Parkinson's disease, multiple sclerosis or motor neurone disease as a cause of death, identified from national mortality data. Results: In this study, 125,242 patients with Parkinson's disease, 23,501 with multiple sclerosis, and 27,030 with motor neurone disease were included. Home deaths ranged from 9.7% (Parkinson's disease) to 27.1% (motor neurone disease), hospice deaths ranged from 0.6% (Parkinson's disease) to 11.2% (motor neurone disease) and hospital deaths ranged from 43.4% (Parkinson's disease) to 55.8% (multiple sclerosis). In Parkinson's disease and multiple sclerosis, cancer as underlying cause of death increased likelihood of hospice death (proportion ratio (PR): 18.8, 95% confidence interval (CI) = 16.1-22.0; 8.88, 95% CI = 7.49-10.5) and home death (PR: 1.91, 95% CI = 1.80-2.04; 1.71, 95% CI = 1.56-1.88). Dementia as underlying cause of death increased likelihood of care home death in Parkinson's disease (PR: 1.25, 95% CI = 1.19-1.32), multiple sclerosis (PR: 1.73, 95% CI = 1.22-2.45) and motor neurone disease (PR: 2.36, 95% CI = 1.31-4.27). Conclusions: Underlying cause of death has a marked effect on place of death. The effects of coding rule changes are an essential consideration for all research using underlying cause of death to study place of death.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Place of death, and its relation with underlying cause of death, in Parkinson’s disease, motor neurone disease, and multiple sclerosis: A population-based study

Sleeman

Verne³

et al. 2013

Palliat Med

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“…Firstly, several studies have argued for an increase in incidence and mortality rates from MS [13] , ALS [14][15][16][17][18] , and PD [19][20][21] in Western countries during the second half of the last century. Whether the trends in the time series might be due to predisposing factors, or, rather, to immediate factors (such as change of registration practice), is an issue open to further analysis.…”

Section: Introductionmentioning

confidence: 99%

Birth Cohort Effects in Neurological Diseases: Amyotrophic Lateral Sclerosis, Parkinson’s Disease and Multiple Sclerosis

et al. 2012

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Background: Generational differences in disease rates are the main subject of age-period-cohort (APC) analysis, which is mostly applied in cancer and suicide research. This study applied APC analysis to selected neurological diseases: amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD) and multiple sclerosis (MS). Methods: The analyses were based on Swiss mortality data. Age-stratified data has been available for MS, PD and ALS since 1901, 1921, and 1942, respectively. APC analysis was performed within the framework of logit models. Main effect models were extended by implementing nested effects, i.e. age effects nested in subperiods, in order to account for the fact that age profiles may change for reasons other than generational influences. Results: In preliminary analyses, APC analysis yielded noteworthy birth cohort effects in all three diseases. After implementing nested effects, the birth cohort effects disappeared in ALS, and smoothed out in PD, where they were greater for the generations born before the 1920s. In MS, the birth cohort effects remained stable, and exhibited a peak in cohorts born in the 1910s and 1920s. Conclusions: APC analysis yielded some evidence for birth cohort effects, i.e. predisposing risk factors that may change in historical terms, in MS and PD, but probably not in ALS.

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“…Instead of evaluating only the physical aspects of the condition, he patient needs to be treated as a whole person [14]. Studying quality of life of those suffering from PD is of utmost importance because it enables monitoring of the functioning with the disease, adjusting to the disease and current state, while it also provides an isight into the overall well-being and life satisfaction [15]. In case of a chronic condition, the state of the patient changes constantly depending on the stage of disease.…”

Section: Quality Of Lifementioning

confidence: 99%

The Effects of Exercise on People with Parkinson’s Disease—Review

Iva¹

2017

APD

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Quality of life encompasses physical, psychological and social aspects of health. Apart from motor symptoms (physical aspects), Parkinson's disease (PD) is also closely related with various non-motor symptoms (psychological and social aspects) that can undermine quality of life greatly, even in early stages of the disease. Most research studies in this field focus on analysis of motor symptoms in PD sufferers. Although benefits of physical activity for the psychosocial quality of life are well-known, they have been mostly neglected in case of the people suffering from PD. Numerous studies clearly show that training programs can ameliorate the quality of life as far as non-motor functions in PD sufferers are concerned. The only psychological aspects of the disease related to the effects of exercise that have been researched so far are depression and cognitive functions. Depression is the most common denominator of poor quality of life, while dementia often accompanies the Parkinson's disease. Studies have shown positive effects of exercise on the social life of those suffering from the disease, especially in case of group exercise. Studying psychological and social aspects of such chronic conditions as PD is of utmost importance for monitoring the patient's adjustment to the disease, functioning with it, as well as the overall well-being and satisfaction with life. Thus far, the results have been pointing towards improvement of the quality of life. Exercise is a readily available method of treatment in case of PD, especially if applied in the early stages of the disease. In addition to reviewing the existing studies on the relation between exercise and quality of life of the patients, this paper will also focus on the way the psychological and social aspects of PD are influenced by exercise.

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Trends in Parkinson’s disease related mortality in England and Wales, 1993–2006

Cited by 30 publications

References 17 publications

Place of death, and its relation with underlying cause of death, in Parkinson’s disease, motor neurone disease, and multiple sclerosis: A population-based study

Place of death, and its relation with underlying cause of death, in Parkinson’s disease, motor neurone disease, and multiple sclerosis: A population-based study

Birth Cohort Effects in Neurological Diseases: Amyotrophic Lateral Sclerosis, Parkinson’s Disease and Multiple Sclerosis

The Effects of Exercise on People with Parkinson’s Disease—Review

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