Parkinson’s disease and risk of hip fracture: systematic review and meta-analysis

Hosseinzadeh, Ali; Khalili, Malahat; Sedighi, Behnaz; Iranpour, Sohrab; Haghdoost, Ali Akbar

doi:10.1007/s13760-018-0932-x

Cited by 15 publications

(20 citation statements)

References 62 publications

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“…Recent reviews demonstrated [3][4][5][6][7][8] that female gender, disease duration and severity, old age, and low BMI are related to osteoporosis, whereas rigidity, bradykinesia, and postural instability (but not tremor) predict falls and increase the risk of osteoporotic fractures. Some authors showed that females and males with PD had significantly lower BMD values at femoral neck, whereas only female patients showed reliable differences in the lumbar spine BMD compared to subjects of control group [20].…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, the relationship between PD and risk of osteoporotic fracture yielded inconsistent results [6][7][8]23]. Recent meta-analysis of prospective studies, which was performed to explore the association between PD and fracture risk (six studies with 69387 participants) [6], found out that PD patients had an increased risk of fracture compared to control subjects (hazard ratio (HR) � 2.66, 95% CI: 2.10-3.36).…”

Section: Discussionmentioning

confidence: 99%

“…Subgroup analysis showed the similar risk in males and females. Another recent systematic review and meta-analysis of published studies concerning association between PD and risk of hip fracture (13 studies with 564947 participants), which was by conducted by Hosseinzadeh et al [8], demonstrated that PD is associated with the risk of hip fracture (HR overall � 3.13, 95% CI: 2.53-3.87); however, it is greater in women than in men.…”

Section: Discussionmentioning

confidence: 99%

“…eir frequency increases with age progressively and their combination can aggravate their own courses. Some recent reviews confirmed the progressive bone loss [1][2][3][4][5] and increased risk of the pain, disability and lowenergy fractures [6][7][8][9] in females with PD; however, the exact mechanisms of osteoporosis and its consequences in PD subjects are unclear. Current studies demonstrate the lower indices of bone mineral density (BMD) in patients with PD; however, these data are contradictory and depends on sex, ethnic, and other features [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson’s Disease

Bystrytska

Povoroznyuk

Grygorieva

et al. 2020

Journal of Osteoporosis

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Osteoporosis and Parkinson’s disease (PD) are two important age-related diseases, which have an influence on pain, physical activity, disability, and mortality. The aim of this research was to study the parameters of bone mineral density (BMD), frequency, and 10-year probability of osteoporotic fractures (OFs) in females with Parkinson’s disease (PD). We have examined 113 postmenopausal women aged 50–74 years old which were divided into 2 groups (I, control group (CG), n = 53 and II, subjects with PD, n = 60). Bone mineral density of lumbar spine, femoral neck, distal radius, and total body were measured, and quantity and localization of vertebral deformities were performed by the vertebral fracture assessment (VFA). Ten-year probability of OFs was assessed by Ukrainian version of FRAX®. It was established that BMD of lumbar spine, femoral neck, distal radius, and total body in PD women was reliably lower compared to CG. The frequency of OFs in PD subjects was higher compared to CG (51.7 and 11.3%, respectively) with prevalence of vertebral fractures (VFs) in women with PD (52.6% among all fractures). 47.4% of the females had combined VFs: 74.2% of VFs were in thoracic part of the spine and 73.7% were wedge ones. Ten-year probability of major OFs and hip fracture were higher in PD women compared to CG with and without BMD measurements. Inclusion of PD in the FRAX calculation increased the requirement of antiosteoporotic treatment from 5 to 28% (without additional examination) and increased the need of additional BMD measurement from 50 to 68%. Anterior/posterior vertebral height ratios (Th8-Th11) measured by VFA in PD females without confirmed vertebral deformities were lower compared to indices of CG. In conclusion, women with PD have lower BMD indices, higher rate of osteoporosis, and risk of future low-energy fractures that should be taken into account in the assessment of their osteoporosis risk and clinical management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson’s Disease

Bystrytska

Povoroznyuk

Grygorieva

et al. 2020

Journal of Osteoporosis

View full text Add to dashboard Cite

show abstract

“…Previous meta-analyses have focused on the general risk of fractures (5,6). A recently published systematic review on the risk of hip fractures excluded studies that only reported event rates without a summary statistic and it excluded studies that included patients with parkinsonism, which may have affected the pooled risk estimate reported (8). Parkinsonism is an atypical form of Parkinson's disease that makes up about 10% of cases and may progress more rapidly than Parkinson's disease and is less responsive to the usual treatment, levodopa.…”

Section: Introductionmentioning

confidence: 99%

The risk of hip and non-vertebral fractures in patients with Parkinson's disease and parkinsonism: A systematic review and meta-analysis

Schini

Vilaça

Poku

et al. 2020

Bone

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Parkinson's disease (PD) is a neurodegenerative disorder that is common in older individuals. PD patients have an increased risk of fractures compared to the general population, perhaps due to multiple falls. However, the fracture risk has not been fully assessed. To assess the impact of PD on the risk of hip and non-vertebral fractures, we conducted a systematic review and meta-analysis. Comprehensive searches of three key bibliographic databases were conducted to identify reviews and primary studies relating to the risk of fractures in patients with PD. Search terms included all relevant terms for Parkinson's disease and for fractures. We selected observational studies with data on the risk of fractures in adults with PD compared to controls without the diagnosis. Study quality was assessed using the Newcastle Ottawa Scale. The random-effects model was used to pool the results. Eighteen studies were included in the review. Seventeen independent studies (14 cohort and 3 case-control studies) were included in the hip fracture analysis. Nine studies (all cohorts, no case-control studies) were included in the non-vertebral fracture analysis. Study quality was judged to be moderate to good. Overall, PD patients had an increased risk for both hip fractures (2.40, 95% CI 2.04 to 2.82) and non-vertebral fractures (1.80, 95% CI 1.60 to 2.01) compared to controls. The relative risk for hip fractures was higher in men (2.93, 95% CI 2.05 to 4.18) than in women (1.81, 95% CI 1.61 to 2.04). There were no effects of the study design, geographical region, or criteria for diagnosing Parkinson's disease on these estimates of fracture risk. There is an increase in the risk of hip and non-vertebral fractures in patients with Parkinson's disease and we recommend a re-evaluation of the clinical guidelines on bone health in patients with PD to address this.

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Fracture risk and impact of osteoporosis in patients with Parkinson’s disease: a nationwide database study

et al. 2022

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Parkinson’s disease and risk of hip fracture: systematic review and meta-analysis

Cited by 15 publications

References 62 publications

Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson’s Disease

Bone Mineral Density and Risk of Osteoporotic Fractures in Women with Parkinson’s Disease

The risk of hip and non-vertebral fractures in patients with Parkinson's disease and parkinsonism: A systematic review and meta-analysis

Fracture risk and impact of osteoporosis in patients with Parkinson’s disease: a nationwide database study

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