Parental Major Depression and the Risk of Depression and Other Mental Disorders in Offspring

Lieb, Roselind; Isensee, Barbara; Höfler, Michael; Pfister, Hildegard; Wittchen, Hans‐Ulrich

doi:10.1001/archpsyc.59.4.365

Cited by 451 publications

(394 citation statements)

References 58 publications

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“…42 The association between parental anxiety and disease management is an important area that needs further study. Another important issue is the familial pattern of symptoms of anxiety, as in general psychopathological symptoms are likely to aggregate in families 43,44 and thus, it is possible that anxious symptoms in caregivers beget anxious symptoms in the child or vice versa. We addressed this issue in a separate paper on symptoms of psychological distress in parent-child dyads which is currently under review.…”

Section: Discussionmentioning

confidence: 99%

Anxiety, depression, and life satisfaction in parents caring for children with cystic fibrosis

Besier

Born

Henrich³

et al. 2011

Pediatric Pulmonology

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Results More than one-third (37.2%) of parents showed elevated levels of anxious symptoms, compared to 18.9% of a population sample (p≤.001) and significantly more parents reported elevated levels of depressive symptoms compared to a community sample (28% vs. 21%, p=.01). Higher levels of anxious and depressive symptoms were associated with lower life satisfaction (p<.001).Conclusions High levels of anxious and depressive symptoms among parents of children with CF suggested that annual symptom screening is warranted. This will facilitate identification of those at risk and provide referrals and intervention for those who are in need of it.

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Section: Discussionmentioning

confidence: 99%

Anxiety, depression, and life satisfaction in parents caring for children with cystic fibrosis

Besier

Born

Henrich³

et al. 2011

Pediatric Pulmonology

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“…Complementary to the findings of studies where offspring are the affected proband, investigations of depressed parents and grandparents have also found increased risk of anxiety (Lieb et al 2002a ;Weissman et al 2005), depression and substance disorders in offspring (e.g. Lieb et al 2002a).…”

Section: Familialitymentioning

confidence: 91%

“…Lieb et al 2002a). The inter-cluster familiality of some of the emotional disorders and some of the externalizing disorders may be explained by common genetically determined vulnerability or by social learning within families.…”

Section: Familialitymentioning

confidence: 99%

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

et al. 2009

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"Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11." Psychological Medicine.39,12. 2043-2059. http://digitalcommons.wustl.edu/open_access_pubs/3923Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11Paper 5 of 7 of the thematic section : ' A proposal for a meta-structure for DSM-V and ICD-11 ' Background. The extant major psychiatric classifications DSM-IV, and ICD-10, are atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis would be greatly enhanced by an understanding of risk factors and clinical manifestations. In an effort to group mental disorders on the basis of aetiology, five clusters have been proposed. This paper considers the validity of the fourth cluster, emotional disorders, within that proposal.Method. We reviewed the literature in relation to 11 validating criteria proposed by a Study Group of the DSM-V Task Force, as applied to the cluster of emotional disorders.Results. An emotional cluster of disorders identified using the 11 validators is feasible. Negative affectivity is the defining feature of the emotional cluster. Although there are differences between disorders in the remaining validating criteria, there are similarities that support the feasibility of an emotional cluster. Strong intra-cluster co-morbidity may reflect the action of common risk factors and also shared higher-order symptom dimensions in these emotional disorders.Conclusion. Emotional disorders meet many of the salient criteria proposed by the Study Group of the DSM-V Task Force to suggest a classification cluster.

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“…Our study adds to the existing evidence in that we were able to account for a range of lifetime factors which could explain associations between early behaviour and ecstasy use, but which had never been accounted for in the literature before. We adjusted for maternal depression and anxiety, which have been found to be associated with children's problem behaviour and substance abuse disorders ( [Alati et al, 2005] and [Lieb et al, 2002a]), and maternal alcohol and tobacco use, and found that these only mildly reduced the strength of the association between delinquent and aggressive behaviour and ecstasy use. Further, this is the first study able to take into account the effect of early use of alcohol and tobacco and the first study to suggest that early experimentation with these licit drugs may explain at least some of the relationship between externalising behaviour in adolescence and later ecstasy use.…”

Section: Strengths Of the Studymentioning

confidence: 99%

“…The authors also found an 81% increase in risk of ecstasy use among those reporting delinquent behaviour in childhood, raising the possibility that another pathway, common to the development of use of other drugs, may also be at play in the development of ecstasy use disorders (King et al, 2004). This may involve an indirect pathway from parental anxiety and depression (Lieb et al, 2002a), to exposure to parental use of tobacco and alcohol (Alati et al, 2005), to children's behavioural problems and early use of licit substances (King et al, 2004). These life course factors are known to predict substance use in youth (Alati et al, 2005), but their influence on regular ecstasy use in particular awaits investigation.…”

Section: Introductionmentioning

confidence: 96%

Pathways to ecstasy use in young adults: Anxiety, depression or behavioural deviance?

Alati¹,

Kinner²,

Hayatbakhsh³

et al. 2008

Drug and Alcohol Dependence

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AimsTo investigate pathways to ecstasy use disorders from pre-birth to early adulthood with particular attention to the relationship between early depressive and anxiety symptoms and later ecstasy use disorders. DesignProspective, longitudinal, population-based study started in Brisbane, South East Queensland (Australia) in 1981. Participants were 2143 young adults, followed up from pre-birth to young adulthood. MeasurementsEcstasy use disorders were assessed with the composite international diagnostic interview (CIDI-Auto). Maternal socio-economic position and mental health status were assessed at baseline (antenatal visit); maternal substance use was measured at the 5-year follow-up, adolescents' behaviour at the 5-and 14-year follow-up and tobacco and alcohol use were assessed at the 14-year follow-up. FindingsEight syndrome scales of childhood behaviour were examined. After adjustment for important confounders, delinquent and aggressive behaviour in early adolescence remained significantly associated with ecstasy use disorders in early adulthood. The associations became statistically non-significant when adolescent tobacco and alcohol use were included in the model [OR = 1.50 (95%CI = 0.75, 3.01) for delinquency and OR = 1.69 (95%CI = 0.92, 3.12) for aggression]. Formal mediation tests were statistically significant (p = 0.001 for delinquent behaviour and p = 0.05 for aggressive behaviour). ConclusionsOur findings suggest a pathway from early deviant behaviour to ecstasy use disorders, possibly mediated through licit drug experimentation in early adolescence.

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Parental Major Depression and the Risk of Depression and Other Mental Disorders in Offspring

Abstract: Major depression in parents increases the overall risk in offspring for onset of depressive and other mental disorders and influences patterns of the natural course of depression in the early stages of manifestation.

Cited by 451 publications

References 58 publications

Anxiety, depression, and life satisfaction in parents caring for children with cystic fibrosis

Anxiety, depression, and life satisfaction in parents caring for children with cystic fibrosis

Emotional disorders: Cluster 4 of the proposed meta-structure for DSM-V and ICD-11

Pathways to ecstasy use in young adults: Anxiety, depression or behavioural deviance?

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