Decreasing life satisfaction has to be considered as a developmental phenomenon. Associations with the increasing prevalence of depression and suicidal ideation during adolescence are discussed. Life satisfaction should be considered a relevant aspect of adolescent's well-being and functioning.

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Taken together, the findings point out that there is a lack of intervention research in psycho-oncology with adolescents. So far, there is only limited evidence for the effectiveness of psychosocial interventions to improve coping with cancer-associated problems in adolescent patients. Future research needs to be done in this population. In order to establish more conclusive results, larger samples and interventions particularly designed for adolescent patients ought to be studied.

Adult survivors of cancer with onset during adolescence are experiencing less LS than the general population. Long-term routine follow-up visits are recommended to identify persisting effects of cancer survival on LS and to provide support for those with special needs. Physicians need to pay special attention to potential risk factors such as psychological distress, somatic late effects, persistent psychological distress, and a lack of posttraumatic growth, which are negatively correlated with LS.

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Results More than one-third (37.2%) of parents showed elevated levels of anxious symptoms, compared to 18.9% of a population sample (p≤.001) and significantly more parents reported elevated levels of depressive symptoms compared to a community sample (28% vs. 21%, p=.01). Higher levels of anxious and depressive symptoms were associated with lower life satisfaction (p<.001).Conclusions High levels of anxious and depressive symptoms among parents of children with CF suggested that annual symptom screening is warranted. This will facilitate identification of those at risk and provide referrals and intervention for those who are in need of it.

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Screening for anxiety/depression and addressing mental health issues within the framework of a family perspective is recommended as an element of routine healthcare for adolescents with CF.