Through-silicon via (TSV)-induced mechanical stress and electrical noise coupling effects on sub 5-nm node nanosheet field-effect transistors (NSFETs) were investigated comprehensively compared to fin-shaped FETs (FinFETs) using TCAD for heterogeneous 3D-ICs. TSV-induced channel length directional stress (SZZ) predominantly causes variations of on-state current (ΔIon). NSFETs exhibit the greater ΔIon than FinFETs because electron velocities and densities in channels vary with respect to SZZ in the same directions for NSFETs but do the opposite for FinFETs. Nevertheless, TSV-induced mechanical stress is negligible when TSV is farther than keep-out zone. Meanwhile, TSV signals can be coupled to operating devices through substrate and induce capacitive and back-bias noise coupling currents (Icap, Ib-b). NSFETs exhibit the greater |Icap|/Ion than FinFETs because its wider source/drain (S/D) epitaxies form larger depletion capacitances between drain and punch-through stopper (PTS). On the other hand, the |Ib-b|/Ion is smaller for NSFETs because its parasitic bottom transistor alleviates back-bias-induced potential barrier lowering. Furthermore, wide diameter of Cu of TSV increases |Ib-b|/Ion only, but short rise time of TSV signals increases both |Icap|/Ion and |Ib-b|/Ion. Unfortunately, conventional devices cannot satisfy criterion for analog applications (|Icap, Ib-b|/Ion< 0.5%); therefore, a new strategy inserting bottom oxide (BOX) beneath the S/D with undoped PTS is suggested. The |Icap|/Ion for NSFETs decreases by undoped PTS, but not for FinFETs due to a remnant depletion capacitance between fin and PTS. The |Ib-b|/Ion for NSFETs decreases remarkably due to completely blocked Ib-b path, but FinFETs still have Ib-b path under the fin. Therefore, NSFETs with BOX and undoped PTS are the most suitable for sub 5-nm node heterogeneous 3D-IC, especially in analog applications.