Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study

Kin, Wong Weng; Nor, Norazmi Mohd; Noordin, Rahmah; Foo, Phiaw Chong; Mohamed, Zeehaida; Haq, Jalaluddin Ashraful; Acosta, Armando; Sarmiento, María E.; Subramaniam, Puvaneswari; Dony, Jiloris F.; Mohamad-Roze, Mohamad-Noor; Osman, Sabariah; Lim, Boon Huat

doi:10.1007/s00436-019-06406-7

Cited by 8 publications

(3 citation statements)

References 45 publications

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“…Under TB patient category, 19 papers [ 4 , 9 – 12 , 21 – 25 , 27 – 29 , 31 – 36 ] reported Ascaris ( A. ) lumbricoides , 18 papers [ 4 , 9 – 12 , 21 – 25 , 27 – 29 , 31 , 33 – 36 ] reported hookworm, 12 papers [ 4 , 10 , 12 , 21 , 22 , 24 , 25 , 27 , 29 , 31 , 35 , 36 ] reported Strongyloides ( S. ) stercoralis , 10 papers [ 4 , 9 , 12 , 21 , 23 , 25 , 29 , 31 , 33 , 35 ] reported Schistosoma ( S. ) mansoni , 16 papers [ 4 , 9 , 11 , 12 , 21 – 29 , 31 , 35 , 36 ] reported Trichuris ( T. ) trichiura , 7 papers [ 11 , 22 , 23 , 25 , 27 , 29 , 32 ] reported Hymenolepis ( H.) nana, and 4 papers each reported Taenia species [ 22 , 25 , 27 , 32 ] and Enterobius ( E. ) vermicularis ...…”

Section: Resultsmentioning

confidence: 99%

Intestinal helminth co-infection and associated factors among pulmonary tuberculosis patients in Africa and Asia: a systematic review and meta-analysis

Zenebe,

Habtamu,

Abebe

et al. 2023

BMC Infect Dis

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Introduction Tuberculosis (TB) and intestinal helminths have huge public health importance, and they are geographically overlapped. Data about the burden of intestinal helminth and TB co-infection in these areas are fragmented. In this systematic review and meta-analysis we compile the current literatures and generate pooled prevalence. We also identity factors associated with intestinal helminth co-infection among TB patients. Methods Original articles published in English language up to March 23, 2022 were systematically searched from electronic database (PubMed/Medline, Scopus, Science Direct, Google Scholars and HINARI). The search was done using medical subject heading terms and keywords. Identified articles were exported into the EndNote library. The identified articles were screened using PRISMA flow diagram. Then the methodological quality of included articles was evaluated and rated using the modified version of Newcastle–Ottawa Scale. Data were extracted using Microsoft Excel. Sensitivity analysis and Egger regression test were used for the assessment of heterogeneity and publication bias. Finally the results are presented with a meta-analysis of pooled estimates, forest plots, and tables. The quantitative data were analyzed using Stata version 14. Results From a total of 5457 searched articles, 22 eligible articles were included in the review. The pooled prevalence of helminth co-infection among TB cases was 29.69% (95%CI: 21.10, 38.29). TB patients were found to more frequently harbor one or more intestinal helminths than TB negative individuals (OR = 1.72 (95%CI: 1.20, 2.48)). Among the reported helminths, Schistosoma mansoni and Strongyloides stercoralis had the highest pooled prevalence among TB cases. However, unlike other individual helminths, only Strongyloides stercoralis (OR = 2.67 (95% CI, 1.20–6.76)) had significant association with TB cases compared to TB negatives. BMI was significantly associated with intestinal helminth co-infection among TB patients (OR = 2.75 (95%CI: 1.19, 6.38)). Conclusions Patients with TB have been shown to harbor co-infection with one or more intestinal helminths with considerable proportions when compared with TB-negative individuals. The higher prevalence of helminth infection in TB cases might indicate that co-infection promotes active TB disease. Thus, routine intestinal helminth screening and assessment of their nutritional status is suggested for TB patients.

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Section: Resultsmentioning

confidence: 99%

Intestinal helminth co-infection and associated factors among pulmonary tuberculosis patients in Africa and Asia: a systematic review and meta-analysis

Zenebe,

Habtamu,

Abebe

et al. 2023

BMC Infect Dis

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“…Moreover, 76.5% of the S. stercoralis seropositive participants were positive for other helminths detected through microscopy. Surveying Orang Asli communities positive for tuberculosis across six states in Malaysia, Wong et al 2019 revealed a seroprevalence of S. stercoralis was 10.9% [ 35 ]. Two more studies on Orang Asli communities reported prevalences of 22.1% and 15.8% [ 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Strongyloides in Southeast Asia: a systematic review and meta-analysis with implications for public health and sustainable control strategies

Chan,

Kusolsuk,

Watthanakulpanich

et al. 2023

Infect Dis Poverty

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Background Strongyloidiasis, caused by the nematodes Strongyloides stercoralis and Strongyloides fuelleborni, is estimated to affect over 600 million individuals worldwide. The disease is endemic in Southeast Asia, where a warm-humid climate and socio-economic conditions maintain the parasite’s life cycle and transmission. However, the current diagnostic methods may not be sufficiently sensitive, suggesting that the true prevalence of strongyloidiasis could be seriously underestimated in this. This study aims to determine the prevalence of strongyloidiasis in Southeast Asia through a systematic review and meta-analysis and to discuss the implications of the estimated prevalence on diagnostic approaches and control strategies. Methods Following PRISMA guidelines, we conducted a systematic literature search in PubMed and Google Scholar databases to identify studies reporting Strongyloides prevalence data in the 11 Southeast Asian countries up to December 2022. A random effects model was employed to estimate the pooled prevalence of S. stercoralis at both regional and country levels. Results Out of 3722 articles identified, 224 met our inclusion criteria. For S. stercoralis specifically, we found 187 articles, of which 52.4% were from Thailand. All Southeast Asian countries, except Brunei, had at least one study on Strongyloides prevalence. The estimated pooled prevalence of S. stercoralis regionally was 12.7% (95% CI 10.70–14.80%), ranging from 0.4 to 24.9% at the country level. Cambodia had the highest pooled prevalence (24.9%, 95% CI 15.65–35.38%), followed by Lao PDR (16.5%, 95% CI 9.50–24.95%). Moreover, we obtained a pooled prevalence of 10% (95% CI 7.06–13.52%) in a group comprising immigrants, workers, and veterans from Southeast Asian countries. S. stercoralis infects various host types, including nonhuman primates, domestic dogs and cats, rodents, and transport carriers such as cockroaches and vegetables. Conclusions A high prevalence of strongyloidiasis in Southeast Asia was revealed, highlighting the importance of the region’s ongoing research, surveillance, and control efforts. Factors contributing to the strongyloidiasis transmission include the role of animal hosts, the impact of global connectivity, and the significance of the co-endemicity of other Strongyloides species. Based on these findings, a multi-pronged One-Health approach is essential for sustainable intervention and control.

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“…The overall number of TB cases in Public health center in Puger has increased by 50% from 2015-2016. Based on Public health center in Puger's data, TB patients were 361 patients during the Wong et al, 2019). TB and chronic helminth co-infection interact actively in modulating the immune system.…”

Section: Introductionmentioning

confidence: 99%

Environmental Sanitation, Personal Hygiene, STH Co-infection in TB Patients

Fitri

Mufida

Hermansyah

et al. 2021

Kemas

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Globally, helminthiasis is one of the infectious diseases that are often associated with the incidence of tuberculosis. Helminth co-infection modulates the immune system of TB patients by reducing Th-1 response that functions as protector against Mycobacterium tuberculosis. This condition disrupts the process of eliminating bacteria so that its development becomes more progressive. The impact is the activation of latent TB and the success of TB treatment. A Soil-transmitted Helminth (STH) is a group of intestinal worms that often infect humans. Previous studies prove that environmental sanitation and personal hygiene are risk factors associated with STH infection. The study to determine the relationship of environmental sanitation and personal hygiene with the incidence of STH co-infection in TB patients at Puskesmas Puger, Jember in September until December 2019. This study uses a cross-sectional design. The sampling technique uses total sampling. A total of 32 TB patients met the criteria as study sample. The data analysis uses Fisher Test. Results showed the prevalence of STH co-infection was relatively low (18.8%); most of the respondents had good environmental sanitation and personal hygiene conditions. Bivariate analysis showed p-value (0,476) for environmental sanitation and p-value (1,000) for personal hygiene. This study concludes that there is no correlation between environmental sanitation, personal hygiene, and STH co-infection in TB patients at Public health center in Puger.

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Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study

Cited by 8 publications

References 45 publications

Intestinal helminth co-infection and associated factors among pulmonary tuberculosis patients in Africa and Asia: a systematic review and meta-analysis

Intestinal helminth co-infection and associated factors among pulmonary tuberculosis patients in Africa and Asia: a systematic review and meta-analysis

Prevalence of Strongyloides in Southeast Asia: a systematic review and meta-analysis with implications for public health and sustainable control strategies

Environmental Sanitation, Personal Hygiene, STH Co-infection in TB Patients

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