Parasitic infection as a potential therapeutic tool against rheumatoid arthritis

Apaer, Shadike; Tuxun, Tuerhongjiang; Ma, Hai‐Zhang; Zhang, Heng; Aierken, Amina; Aini, Abudusalamu; Li, Yupeng; Lin, Renyong; Wen, Hao

doi:10.3892/etm.2016.3660

Cited by 5 publications

(5 citation statements)

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“…Although the potential efficacy of Echinococcus sp. components to treat rheumatoid arthritis was also evoked, it does not seem to have been demonstrated yet (308). The strongest evidence for the immunoregulatory role of established Echinococcus sp.…”

Section: Improving Understanding Of Immunological Mechanisms Of Host-mentioning

confidence: 99%

Echinococcosis: Advances in the 21st Century

Wen¹,

Vuitton²,

et al. 2019

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SUMMARY Echinococcosis is a zoonosis caused by cestodes of the genus Echinococcus (family Taeniidae). This serious and near-cosmopolitan disease continues to be a significant public health issue, with western China being the area of highest endemicity for both the cystic (CE) and alveolar (AE) forms of echinococcosis. Considerable advances have been made in the 21st century on the genetics, genomics, and molecular epidemiology of the causative parasites, on diagnostic tools, and on treatment techniques and control strategies, including the development and deployment of vaccines. In terms of surgery, new procedures have superseded traditional techniques, and total cystectomy in CE, ex vivo resection with autotransplantation in AE, and percutaneous and perendoscopic procedures in both diseases have improved treatment efficacy and the quality of life of patients. In this review, we summarize recent progress on the biology, epidemiology, diagnosis, management, control, and prevention of CE and AE. Currently there is no alternative drug to albendazole to treat echinococcosis, and new compounds are required urgently. Recently acquired genomic and proteomic information can provide a platform for improving diagnosis and for finding new drug and vaccine targets, with direct impact in the future on the control of echinococcosis, which continues to be a global challenge.

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Section: Improving Understanding Of Immunological Mechanisms Of Host-mentioning

confidence: 99%

Echinococcosis: Advances in the 21st Century

Wen¹,

Vuitton²,

et al. 2019

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“…Though it was also suggested that Echinococcus sp. substances would be effective in treating rheumatoid arthritis, this has not yet been proven (Apaer et al 2016). The observations in the experimental colitis study provide the best support for regulating the immune function of developed Echinococcus spp.…”

Section: Fig 3: Major Products Produced As a Response To Hydatid Cyst...mentioning

confidence: 94%

Echinococcosis: Recent Advancements in OMIC Technologies

2023

IJAB

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Cystic echinococcosis (CE) and alveolar echinococcosis (AE), two severe zoonotic tapeworm infections caused by Echinococcus granulosus sensu lato and Echinococcus multilocularis, respectively, are referred to as echinococcosis (McManus et al. 2012). The yearly occurrence of CE varies from 1 to 200 / 100,000 people in endemic regions, whereas the incidence of AE varies between 0.03 to 1.2 / 100,000 people (Schweiger et al. 2007). Ninety percent of AE patients who receive no treatment or insufficient treatment die within 10 to 15 years after their diagnosis (Budke et al. 2013). Although the CE fatality rate (2% to 4%) is less it might rise significantly in cases of insufficient care management. Echinococcosis is one of the 17 neglected illnesses that the World Health Organization (WHO) hopes to manage or eradicate by 2050. While CE is more prevalent and has a cosmopolitan distribution, several countries have claimed it to be eliminated (Craig and Larrieu 2006;Craig et al. 2007). Still, the disease is distributed all over the world with high prevalence in Asian, American, and African countries as given

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“…The development of an immunologically healthy condition because of helminth infection is thought to mitigate the incidence of an autoimmune rheumatic disorder that is present. A deeper understanding of the anti-inflammatory mechanisms triggered by helminth infection or their secretory products is remained elusive [92,93].…”

Section: Protective Role Of Parasites In Autoimmune Diseasesmentioning

confidence: 99%

Impact of parasitic infection on human gut ecology and immune regulations

Ahsan

Abdullah

2021

transl med commun

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The human body harbors trillions of microbes collectively known as microbiota. The human gut microbiota is importantly involved in most of the human metabolic and regulatory pathways. The gut microbiota needs to be balanced for the health of the host. Several factors are involved in the distribution of microbiota in the human body, in most cases these microbiotas are commensals, but some circumstances lead to serious disorders and the development of infections from microbiota. When parasites colonize the gut, the balance between the host and the gut microbiota can be disturbed. Parasitic invasion in the gut is associated with unhygienic conditions including contaminated food and water. Parasitic invasion in the gut induces the immune response to recognize and eliminate pathogens. The current study highlights the immune system’s response to disruption of normal intestinal microbiota and parasitic infections.

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Parasitic infection as a potential therapeutic tool against rheumatoid arthritis

Cited by 5 publications

References 113 publications

Echinococcosis: Advances in the 21st Century

Echinococcosis: Advances in the 21st Century

Echinococcosis: Recent Advancements in OMIC Technologies

Impact of parasitic infection on human gut ecology and immune regulations

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