Impact of parasitic infection on human gut ecology and immune regulations

Ahsan, Naveed; Abdullah, Sabahat

doi:10.1186/s41231-021-00091-4

Cited by 14 publications

(9 citation statements)

References 88 publications

(84 reference statements)

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“…Previous studies have also indicated that the parasite Trichuris suis significantly affects the microbiota diversity in the colons of pigs. Moreover, the diversity and composition of the human gut microbiota has been found to be threatened by Necator americanus and other helminth parasites ( Naveed and Abdullah, 2021 ). In PA, host homeostasis was negatively affected by losses and shifts in the core microbiota.…”

Section: Discussionmentioning

confidence: 99%

Effects of scale worm parasitism on interactions between the symbiotic gill microbiome and gene regulation in deep sea mussel hosts

et al. 2022

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Diverse adaptations to the challenging deep sea environment are expected to be found across all deep sea organisms. Scale worms Branchipolynoe pettiboneae are believed to adapt to the deep sea environment by parasitizing deep sea mussels; this biotic interaction is one of most known in the deep sea chemosynthetic ecosystem. However, the mechanisms underlying the effects of scale worm parasitism on hosts are unclear. Previous studies have revealed that the microbiota plays an important role in host adaptability. Here, we compared gill-microbiota, gene expression and host-microorganism interactions in a group of deep sea mussels (Gigantidas haimaensis) parasitized by scale worm (PA group) and a no parasitic control group (NPA group). The symbiotic microorganism diversity of the PA group significantly decreased than NPA group, while the relative abundance of chemoautotrophic symbiotic bacteria that provide the host with organic carbon compounds significantly increased in PA. Interestingly, RNA-seq revealed that G. haimaensis hosts responded to B. pettiboneaei parasitism through significant upregulation of protein and lipid anabolism related genes, and that this parasitism may enhance host mussel nutrient anabolism but inhibit the host’s ability to absorb nutrients, thus potentially helping the parasite obtain nutrients from the host. In an integrated analysis of the interactions between changes in the microbiota and host gene dysregulation, we found an agreement between the microbiota and transcriptomic responses to B. pettiboneaei parasitism. Together, our findings provide new insights into the effects of parasite scale worms on changes in symbiotic bacteria and gene expression in deep sea mussel hosts. We explored the potential role of host-microorganism interactions between scale worms and deep sea mussels, and revealed the mechanisms through which scale worm parasitism affects hosts in deep sea chemosynthetic ecosystem.

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Section: Discussionmentioning

confidence: 99%

Effects of scale worm parasitism on interactions between the symbiotic gill microbiome and gene regulation in deep sea mussel hosts

et al. 2022

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“…In contrast, Dostal et al (2014) did not observe a significant effect on the gut microbiota in 6- to 11-year-old children living in South Africa following 38 weeks of iron supplementation (50 mg iron for 4 days/week) ( 23 ). These results highlight that study context is critical as many factors, including hygiene, diet, and parasite burden, can affect gut microbial composition ( 24 , 25 ). Furthermore, it is important to note that infant and childhood microbiomes are considered to be less stable and diverse than adult microbiomes ( 26 ).…”

Section: Discussionmentioning

confidence: 91%

The Effect of Oral Iron Supplementation on Gut Microbial Composition: a Secondary Analysis of a Double-Blind, Randomized Controlled Trial among Cambodian Women of Reproductive Age

Finlayson-Trick,

Nearing,

Fischer

et al. 2023

Microbiol Spectr

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To the best of our knowledge, this is the first published study to characterize the effects of oral iron supplementation on the gut microbiomes of Cambodian WRA. Our study found that iron supplementation with ferrous bisglycinate increases the relative abundance of Enterobacteriaceae , which is a family of bacteria that includes many Gram-negative enteric pathogens like Salmonella , Shigella , and Escherichia coli .

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“…Although some helminths can enhance the gut-barrier function, restrict bacterial translocation and induce a tolerogenic phenotype of resident muscularis macrophages, which are trained guardians of enteric neurons [ 126 , 127 ], virulent parasitic protozoa can have reverse effects, damaging the gut-barrier function and enteric neurons [ 128 ].…”

Section: Pathogens and Ens Development And Diseasementioning

confidence: 99%

The Potential Role of Microorganisms on Enteric Nervous System Development and Disease

2023

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The enteric nervous system (ENS), the inherent nervous system of the gastrointestinal (GI) tract is a vast nervous system that controls key GI functions, including motility. It functions at a critical interface between the gut luminal contents, including the diverse population of microorganisms deemed the microbiota, as well as the autonomic and central nervous systems. Critical development of this axis of interaction, a key determinant of human health and disease, appears to occur most significantly during early life and childhood, from the pre-natal through to the post-natal period. These factors that enable the ENS to function as a master regulator also make it vulnerable to damage and, in turn, a number of GI-motility disorders. Increasing attention is now being paid to the potential of disruption of the microbiota and pathogenic microorganisms in the potential aetiopathogeneis of GI-motility disorders in children. This article explores the evidence regarding the relationship between the development and integrity of the ENS and the potential for such factors, notably dysbiosis and pathogenic bacteria, viruses and parasites, to impact upon them in early life.

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Impact of parasitic infection on human gut ecology and immune regulations

Cited by 14 publications

References 88 publications

Effects of scale worm parasitism on interactions between the symbiotic gill microbiome and gene regulation in deep sea mussel hosts

Effects of scale worm parasitism on interactions between the symbiotic gill microbiome and gene regulation in deep sea mussel hosts

The Effect of Oral Iron Supplementation on Gut Microbial Composition: a Secondary Analysis of a Double-Blind, Randomized Controlled Trial among Cambodian Women of Reproductive Age

The Potential Role of Microorganisms on Enteric Nervous System Development and Disease

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