Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: A role for PPAR-γ pathway

Khateeb, Jasmin; Gantman, Anna; Kreitenberg, Adam J.; Aviram, Michael; Fuhrman, Bianca

doi:10.1016/j.atherosclerosis.2009.08.051

Cited by 141 publications

(109 citation statements)

References 28 publications

(31 reference statements)

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“…In vivo, different mechanisms have been suggested for antiatherogenic activity of pomegranate extractions, especially juice, such as reduction of oxidant enzyme activities (Schubert et al, 1999), inducing antioxidant enzymes expression (Khateeb, Gantman, Kreitenberg, Aviram, & Fuhrman, 2010), enhancing nitric oxide activity , inhibiting cellular uptake of oxidized LDL and cholesterol biosynthesis (Fuhrman et al, 2005). However, the present in-vitro study showed a direct inhibitory effect of the W fraction and not PSOs of pomegranate on copper-induced LDL oxidation.…”

Section: Discussioncontrasting

confidence: 52%

Effects of pomegranate seed oil and fermented juice polyphenols fraction in different solvents on copper-induced LDL oxidation

Faisi

Fattahi

Raffel

et al. 2018

CyTA - Journal of Food

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Effects of pomegranate seed oils extracted with supercritical fluid or cold press methods (SFE-PSO and CP-PSO), unsaponifiable (N), and fermented juice polyphenols (W) fractions of pomegranate as well as olive oil and alpha-tocopherol, as pure or in different solvents were evaluated on preventing copper-induced LDL oxidation. The results showed addition of pure SFE-PSO, CP-PSO, N fractions, and olive oil had no significant effect on LDL oxidation. Also using various solvents did not help in the term of extending the oxidation lag phase. However, adding 0.5, 1, 1.5, and 3 µL of the W solution in EtOH could delay the lag phase 103.5, 145.9, 200, and 199.1 min, respectively. There was no synergistic effect between W and N on inhibiting the oxidation. It can be concluded that polyphenolic fraction of pomegranate juice can act as antiatherogenic supplementation and natural preservative for meat and fatty foods through direct inhibition of LDL oxidation.Efectos del aceite de semilla de granada y la fracción polifenólica de jugo fermentado, mezclados con distintos solventes, en la oxidación de LDL inducida por cobre RESUMEN A efectos de prevenir la oxidación de LDL inducida por cobre, el presente estudio se propuso evaluar los efectos que los aceites de semilla de granada extraídos con fluido supercrítico o métodos de presión en frío (SFE-PSO y CP-PSO), y las fracciones polifenólicas de jugo de granada fermentado e insaponificable (N), así como el aceite de oliva y el alfa-tocoferol, tienen en estado puro o en distintos solventes. Los resultados mostraron que la adición de fracciones SFE-PSO, CP-PSO, N puras y aceite de oliva no produjo ningún efecto significativo en la oxidación de LDL. Por otra parte, el uso de varios solventes no contribuyó a extender la fase de latencia de la oxidación. Sin embargo, al agregar 0.5, 1, 1.5 y 3 µl de la solución W en EtOH se pudo retrasar la fase de latencia 103.5, 145.9, 200 y 199.1 minutos, respectivamente. No se produjo ningún efecto sinérgico entre W y N en la inhibición de oxidación. Por lo tanto, se concluye que la fracción polifenólica del jugo de granada puede actuar como suplemento antiaterogénico y conservador natural de carnes y alimentos grasos mediante la inhibición directa de la oxidación de LDL. ARTICLE HISTORY

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Section: Discussioncontrasting

confidence: 52%

Effects of pomegranate seed oil and fermented juice polyphenols fraction in different solvents on copper-induced LDL oxidation

Faisi

Fattahi

Raffel

et al. 2018

CyTA - Journal of Food

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“…The plausible explanation for their antiglycation abilities is a downregulation of RAGE-mRNA expression, which is an integral part of RAGE formation [20]. PPAR gamma, a member of the nuclear receptor proteins, has a pivotal role in carbohydrates and lipids metabolisms, via downregulation of RAGE expression or upregulation of paraoxonase-1 expression, a HDL-associated lipolactonase with antioxidative properties [104]. PPAR alpha plays a role to improve inflammation by inhibition of expression of related genes.…”

Section: Regulation Of Gene Expressionmentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

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“…LDL receptor deficient mice supplemented with quercitine (a polyphenol contained in pomegranate) and moderate ethanol inhibited the progression of atherosclerosis by upregulating the hepatic expression with concomitant increased serum PON1 activity (Gouédard et al, 2004;Leckey et al, 2010). Similarly, pomegranate polyphenols seem to have a specific transcriptional role in hepatocyte PON1 expression upregulation (Khateeb et al, 2010). Although it is known that diabetes is associated with increased oxidative stress and the development of atherosclerosis (Mooradian, 2009), no expression studies have been examined in a diabetic model that is fed with high fat.…”

Section: Antidiabetic Properties (Glucose and Lipid Metabolism Activity)mentioning

confidence: 99%

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

Akpinar‐Bayizit¹,

Özcan²,

Yilmaz‐Ersan³

2012

Cancer Prevention - From Mechanisms to Translational Benefits

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Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: A role for PPAR-γ pathway

Cited by 141 publications

References 28 publications

Effects of pomegranate seed oil and fermented juice polyphenols fraction in different solvents on copper-induced LDL oxidation

Effects of pomegranate seed oil and fermented juice polyphenols fraction in different solvents on copper-induced LDL oxidation

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

The Therapeutic Potential of Pomegranate and Its Products for Prevention of Cancer

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