Paraoxonase-1 and arylesterase levels in patients with ulcerative colitis

Şahin, Muammer Melih; Bobuşoğlu, Onur; Yetim, Aylin; Ateş, Fehmi

doi:10.1016/j.ajg.2019.01.009

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…In agreement with tight association between PON1 and both clinical activity and severity of inflammation, Sahin et al [46] found arylesterase activity of the enzyme in UC patients to be predicted by MDAI score and leukocyte count (if not otherwise stated, discussed results are in Table S2).…”

Section: Progression Markers In Ucsupporting

confidence: 54%

“…Boehm et al [45] reported a drop in PON1 in both CD and UC patients, indicative of their presence with 74% and 65% accuracy, a finding corroborated by Yuksel et al [20], who found PON1 to be an independent predictor of IBD (Table 1). Only recently these observations were supported by Sahin et al [46] measuring arylesterase activity in UC patients (Supplementary Table S2). Collected data is less consistent regarding enzyme activity towards paraoxon [47] (Table 1) [46,48] (Supplementary Table S3), what should not come as a surprise, as none of the authors analyzed PON1 phenotype distribution.…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 63%

“…Only recently these observations were supported by Sahin et al [46] measuring arylesterase activity in UC patients (Supplementary Table S2). Collected data is less consistent regarding enzyme activity towards paraoxon [47] (Table 1) [46,48] (Supplementary Table S3), what should not come as a surprise, as none of the authors analyzed PON1 phenotype distribution. Unfortunately, analyzing PON1 paraoxonase activity without accounting for enzyme phenotypes is of limited value.…”

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 63%

“…In general, albumin has also been reported to be lower in active IBD [24] or specifically in active CD [51,111]. Albumin inversely correlated with CDAI and CRP [46,111]. Somehow confusing results were reported by [25] showing decreased albumin in IBD patients, and in the same time its positive correlation with clinical disease activities.…”

Section: Progression Markers In CDmentioning

confidence: 99%

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Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

et al. 2020

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Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD. A Pubmed, Web of Knowledge, and Scopus search of original articles on OSMs in IBD, published between January 2000 and April 2020, was conducted. Out of 874 articles, 79 eligible studies were identified and used to prepare the interpretative synthesis. Antioxidants followed by lipid peroxidation markers were the most popular and markers of oxidative DNA damage the least popular. There was a disparity in the number of retrieved papers evaluating biomarkers in the adult and pediatric population (n = 6). Of the reviewed OSMs, a promising performance has been reported for serum total antioxidant status as a mucosal healing marker, mucosal 8-OHdG as a progression marker, and for multi-analyte panels of lipid peroxidation products assessed non-invasively in breath as diagnostic and differential markers in the pediatric population. Bilirubin, in turn, was the only validated marker. There is a desperate need for non-invasive biomarkers in IBD which, however, will not be met in the near future by oxidative stress markers as they are promising but mostly at the early research phase of discovery.

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Section: Progression Markers In Ucsupporting

confidence: 54%

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 63%

Section: Diagnostic Markers In Ibd (Markers Not Specific For Either Umentioning

confidence: 63%

Section: Progression Markers In CDmentioning

confidence: 99%

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Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

et al. 2020

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“…ARE acts as a significant component of the enzymatic antioxidant system with PON-1, which has the same functions. Moreover, both PON-1 and ARE interact to form a significant component of the enzymatic plasma antioxidant system (Sahin et al, 2019). Shenhar TS and colleagues found that ARE was significantly lower in acute stroke patients who had any degree of white matter lesion (WML) than WML-free patients (Shenhar-Tsarfaty et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Relationship between arylesterase activity and pulse pressure index in patients with an acute ischemic stroke

Öztürk¹,

Öztürk²,

Öztürk³

2021

JECM

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Stroke is a multifactorial disease. Arylesterase (ARE) activities have been considered as an anti-atherosclerosis factor. Increased pulse pressure (PP) may lead to a high risk of coronary artery disease and neurovascular morbidity and mortality. Nevertheless, there are limitations for PP as an evaluation index. In order to overcome the defects of PP, there is a novel parameter, “pulse pressure/systolic pressure” named “pulse pressure index (PPI)” for evaluation of cardiovascular effect. We researched the relationship between ARE activities and pulse pressure index (PPI) in acute ischemic stroke patients. We evaluated and compared the ARE activity and PPI in 87 ischemic stroke patients and 48 control patients. ARE activity was measured with the ultraviolet (UV) spectrophotometric method by using “Rel Assay Diagnostic” kits. Pulse pressure was measured by subtraction of diastolic blood pressure from systolic blood pressure. PPI was calculated as “pulse pressure / systolic pressure”. Hypertension, age, diabetes mellitus, dyslipidemia importantly higher in ischemic stroke patients than the control group (p<0.05). PPI was significantly higher in ischemic stroke patients than the control group (0.486±0.075 and 0.417±0.051, p<0.05). ARE activity was significantly lower in ischemic stroke patients than in the control group (511.59 ± 68.51 and 584.16 ± 81.74 p=0.019). This study demonstrated that ARE activity is lower and PPI is higher in acute ischemic stroke patients than control subjects. Our results suggested that, ARE activity and PPI are important risk factors in acute ischemic stroke patients.

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Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis

Chen,

Li,

et al. 2023

Front. Med.

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BackgroundSerum lipid levels seem to be abnormal in Inflammatory bowel disease (IBD). However, the specific manifestation of abnormal serum lipid levels in IBD are heterogeneous among studies and have not been sufficiently determined yet.MethodsPubMed, EMBASE, and Cochrane Library databases were searched. Serum lipid levels were compared between IBD patients and Health individuals, Crohn’s (CD) and ulcerative colitis (UC), active and inactive, mild and non-mild patients, respectively. Meta-analyses were performed by using a random-effect model. Weight mean difference (WMD) with 95% confidence intervals (CIs) were calculated.ResultsOverall, 53 studies were included. Compared with healthy controls, IBD patients had significantly lower TC (WMD = −0.506, 95%CI = −0.674 to −0.338, p < 0.001), HDL-c (WMD = −0.122, 95%CI = −0.205 to −0.039, p = 0.004), and LDL-c (WMD = −0.371, 95%CI = −0.547 to −0.194, p < 0.001) levels. CD groups had a significantly lower TC (WMD = −0.349, 95%CI = −0.528 to −0.170, p < 0.0001) level as compared to UC groups. Active IBD and non-mild UC groups had significantly lower TC (WMD = −0.454, 95%CI = −0.722 to −0.187, p = 0.001) (WMD =0.462, 95%CI = 0.176 to 0.748, p = 0.002) and LDL-c (WMD = −0.225, 95%CI = −0.445 to −0.005, p = 0.045) (WMD =0.346, 95%CI = 0.084–0.609, p = 0.010) levels as compared to inactive IBD and mild UC groups, respectively.ConclusionThe overall level of serum lipids in IBD patients is lower than that of healthy individuals and is negatively associated with disease severity.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022383885.

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Paraoxonase-1 and arylesterase levels in patients with ulcerative colitis

Cited by 5 publications

References 18 publications

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

Relationship between arylesterase activity and pulse pressure index in patients with an acute ischemic stroke

Association of serum lipids with inflammatory bowel disease: a systematic review and meta-analysis

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