Paranasal Sinus Mucosal Regeneration: The Effect of Topical Retinoic Acid

Maccabee, Mendy; Trune, Dennis R.; Hwang, Peter H.

doi:10.1177/194589240301700304

Cited by 20 publications

(22 citation statements)

References 15 publications

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“…As previously noted, all rabbits in this study had the right maxillary sinus opened but untreated to serve as an internal control, regardless of whether the mucosa was stripped or left intact. Described by others 1,10–13 and demonstrated in Figure 2A, the normal respiratory mucosa of the maxillary sinus in the rabbit consisted of layered pseudostratified ciliated epithelium with goblet and basal cells on the basal lamina. Numerous blood vessels and serous glands are found deep to the basal lamina.…”

Section: Resultsmentioning

confidence: 67%

Hemostatic Agent Microporous Polysaccharide Hemospheres (MPH) Does Not Affect Healing or Intact Sinus Mucosa

et al. 2008

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Section: Resultsmentioning

confidence: 67%

Hemostatic Agent Microporous Polysaccharide Hemospheres (MPH) Does Not Affect Healing or Intact Sinus Mucosa

et al. 2008

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“…Although the regenerated mucosa was still grossly abnormal, the degree of ciliary loss and cellular derangement was reduced. The group receiving the low concentration of retinoic acid had more favorable morphology than that receiveing a high concentration, and both groups improved when compared with the control group [15]. Another study examined the effect of retinoic acid on sinusitis.…”

Section: Discussionmentioning

confidence: 93%

Activation of vocal fold healing with topical vitamin A in rabbits

Akdoğan

Selçuk

Özcan

et al. 2009

Acta Oto-Laryngologica

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“…Although most of these studies have focused on wounds in the skin, [11][12][13][14][15][16][17] retinoid efficacy has also been demonstrated in healing of wounds in other tissues-bone, cornea, respiratory tract, upper digestive system, and gut. [18][19][20][21][22][23][24][25] Although retinoids have beneficial activities, skin irritation is commonly seen following topical application of RA. [26][27][28] If skin irritation is too severe, retinoid use will simply be discontinued by most users.…”

Section: Discussionmentioning

confidence: 99%

MDI 301, a nonirritating retinoid, improves abrasion wound healing in damaged/atrophic skin

Warner

Bhagavathula

Nerusu

et al. 2008

Wound Repair Regeneration

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MDI 301 is a picolinic acid-substituted ester of 9-cis retinoic acid. It has been shown in the past that MDI 301 increases epidermal thickness, decreases matrix metalloproteinase (MMP) activity, and increases procollagen synthesis in organ-cultured human skin. Unlike all-trans retinoic acid (RA), MDI 301 does not induce expression of proinflammatory cytokines or induce expression of leukocyte adhesion molecules in human skin. In the present study we examined topical MDI 301 treatment for ability to improve the structure and function of skin in three models of skin damage in rodents and for ability to improve abrasion wound healing in these models. MDI 301 was applied daily to the skin of rats treated with the potent corticosteroid, clobetasol propionate, to the skin of diabetic rats (8 weeks posttreatment with streptozotocin) and to the skin of aged (14-16-month-old) rats. In all three models, subsequently induced abrasion wounds healed more rapidly in the retinoid-treated animals than in vehicle-treated controls. Immediately after complete wound closure, tissue from the wound site (as well as from a control site) was put into organ culture and maintained for 3 days. At the end of the incubation period, culture fluids were assessed for soluble type I collagen and for MMPs-2 and -9. In all three models, the level of type I collagen was increased and MMP levels were decreased by MDI 301. In all three models, skin irritation during the retinoid-treatment phase was virtually nonexistent.Minor abrasions that occur in healthy skin are expected to heal without incident. Interventions are designed primarily to prevent infection and to provide support for the body's own regenerative mechanisms. In contrast, wounds in chronically damaged and atrophic skin often go on to form nonhealing ulcers with devastating consequences. Diabetes alone is a contributing factor in up to 70% of the > 55,000 amputations that occur annually. [1][2][3][4] Skin that has become atrophic as a consequence of the aging process also demonstrates impaired wound healing, 5-7 as does skin that has been damaged as a result of extended corticosteroid use. [8][9][10] The majority of wound-healing research is directed toward understanding the pathophysiology of impaired wound healing and identifying interventions that can mitigate the critical patho-physiological events.Several past studies have demonstrated the efficacy of all-trans retinoic acid (RA) and its parent compound all-trans retinol (ROL, vitamin A) in wound healing. Although most studies have focused on wounds in the skin, [11][12][13][14][15][16][17] retinoid efficacy has also been demonstrated in healing of wounds in other tissues (bone, cornea, respiratory tract, upper digestive system, and gut). 27 Likewise, skin irritation is also a complication with synthetic retinoidal agents currently on the market. 28 Irritation is a major cause of non-compliance among retinoid users. In addition, excessive irritation may counteract the beneficial effects of retinoid use or actually predispo...

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Paranasal Sinus Mucosal Regeneration: The Effect of Topical Retinoic Acid

Abstract: In a rabbit model, topical vitamin A in the form of retinoic acid gel appears to enhance regeneration of ciliated paranasal sinus mucosa. This preliminary study suggests that topical retinoids may have applicability in promoting sinus wound healing.

Cited by 20 publications

References 15 publications

Hemostatic Agent Microporous Polysaccharide Hemospheres (MPH) Does Not Affect Healing or Intact Sinus Mucosa

Hemostatic Agent Microporous Polysaccharide Hemospheres (MPH) Does Not Affect Healing or Intact Sinus Mucosa

Activation of vocal fold healing with topical vitamin A in rabbits

MDI 301, a nonirritating retinoid, improves abrasion wound healing in damaged/atrophic skin

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