Hemostatic Agent Microporous Polysaccharide Hemospheres (MPH) Does Not Affect Healing or Intact Sinus Mucosa

Antisdel, Jastin L.; Janney, Christine G.; Long, J. P.; Sindwani, Raj

doi:10.1097/mlg.0b013e31816c7bc9

Cited by 52 publications

(53 citation statements)

References 14 publications

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“…MPH was found to be associated less with mucosal cilia loss, inflammation and fibrosis in a study comparing MPH and floseal following surgical intervention to the maxillary sinus in rabbits by Antisdel et al (1). In our study, no difference in neuronal degeneration between ORC and MPH was detected.…”

Section: Mph (Microporous Polysaccharide Hemospheres)mentioning

confidence: 40%

Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety

Emmez

Tönge²,

Tokgöz³

et al. 2010

Turkish Neurosurgery

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AIM: Topical hemostatic agents are widely used in brain surgery but they have some disadvantages such as foreign body reaction, being a focus for infection and causing artifacts in radiological examinations. The purpose of this study is to compare the effectiveness and safety of microporous polysaccharide hemospheres (MPH) with a well known agent, oxidized regenerated cellulose (ORC), histopathologically and radiologically. MATeRIAL and MeTHodS: Standard brain lesions (4x1mm) were created in 24 hemispheres in 12 New-Zealand rabbits. Animals were divided into three groups; control, ORC and MPH. Twenty-four hours later, all rabbits magnetic resonance brain imaging. After imaging, the animals were sacrificed and the brains were removed for histopathological analysis. ReSULTS: Histopathological analysis showed no significant difference between the groups. Radiological examination showed no significant difference between the MPH and ORC groups in terms of edema but the edema in control group was significantly prominent than MPH and ORC groups (p<0.001). CoNCLUSIoN: A new agent (MPH) provides safe and effective hemostasis in the brain in this study. The most important advantage of microporous polysaccharide hemospheres is their rapid clearance from the surgical field and therefore having the potential of causing less imaging artifacts.

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Section: Mph (Microporous Polysaccharide Hemospheres)mentioning

confidence: 40%

Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety

Emmez

Tönge²,

Tokgöz³

et al. 2010

Turkish Neurosurgery

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“…The rapid absorption kinetics and composition of MPH also explain why this material does not interfere with the mucosal regeneration and wound healing. 4 The 'no treatment' control used in this study permits comparison to what the patient would otherwise have experienced as 'normal recovery' from surgery. A noteworthy fi nding was that the use of MPH did not signifi cantly alter the pain, obstruction, or discharge that patients experienced following ESS.…”

Section: Resultsmentioning

confidence: 99%

“…Importantly, MPH does not impact healing or intact sinus mucosa in animals. 4 Acting as a 'molecular sieve' by osmotically extracting fl uids from blood, MPH particles concentrate platelets and other elements promoting the formation of a fi brin clot. Unlike most agents which are derived from animal products, MPH is made from purifi ed potato starch and is hypoallergenic with no inherent risk of disease transmission.…”

mentioning

confidence: 99%

“…Recently, concerns over the use of long-lasting bioabsorbables have been raised in response to studies demonstrating that these agents may interfere with normal mucosal healing and contribute to granulation and adhesion formation. [4][5][6][7] Microporous Polysaccharide Hemospheres (MPH®, commercially available as Arista® and Hemaderm®; Medafor, Inc., Minneapolis, MN) is a novel and rapidly cleared absorbable hemostatic powder. Importantly, MPH does not impact healing or intact sinus mucosa in animals.…”

mentioning

confidence: 99%

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Effect of Hemostatic Agent MPH® on Bleeding after Endoscopic Sinus Surgery: A Prospective Randomized Controlled Study

Antisdel¹,

West-Denning²,

Sindwani³

2009

The Laryngoscope

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Absorbable hemostatic agents are commonly used after endoscopic sinus surgery (ESS). MPH® (Microporous Polysaccharide Hemospheres) is a novel hemostatic powder that is rapidly absorbed. The goal of this study was to examine the eff ects of MPH on bleeding after ESS.STUDY DESIGN: Prospective blinded randomized controlled study. METHODS:Patients undergoing bilateral ESS for CRS by the same surgeon were randomized to treatment with MPH of only one-side of the nose at the conclusion of surgery. The other side was untreated and served as a control. All patients received standard postoperative management. Patients completed symptom diaries using visual analogue scales (VAS, scored out of 100) at baseline and through postoperative day (POD) 30. Outcomes including bleeding, pain, obstruction, and nasal discharge were recorded separately for left and right sides. RESULTS:Forty patients (19 men, 21 women) with an average age of 48.6 yrs were included. There were no complications and all patients were discharged home the same day. The mean bleeding score on POD 1 for MPH-treated sides was 22.5 versus 39.0 for untreated controls (mean reduction 16.5, p<0.0001, 95% CI -23.2 to -9.7). The scores for bleeding at baseline and at all other post-treatment days were not signifi cantly diff erent (p>0.05). There were no other signifi cant diff erences between MPH-treated and control sides in any of the other variables measured throughout the study period.CONCLUSION: Application of MPH signifi cantly reduces bleeding in the immediate postoperative period following ESS.

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“…23,25 Gelatin thrombin matrix: It stops bleeding on an average of 2 minutes. 26 Some studies reported its adverse effect, 27,28,29 but one study evaluated its efficiency without complications. 30 Others: Microporous polysaccharide hemispheres, 31,32 oxidised methylcellulose, 33 fibrin glue, 34 microfibrillar collagen 35 and gelatin sponges 36 can be used to control intraoperative bleeding.…”

Section: Surgical Considerationsmentioning

confidence: 99%

Anaesthetic Concerns in Functional Endoscopic Sinus Surgery

R¹,

Naik²

2017

jemds

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BACKGROUNDFunctional endoscopic sinus surgery provides a challenge and an opportunity for the anaesthesiologists to provide surgeons with a surgical field, which can make this delicate surgery more safe, fast and precise. The article discusses causes of bleeding in functional sinus surgery. MATERIALS AND METHODSIt focuses on various techniques and drugs, which can be used by anaesthesiologists to control bleeding. It also discusses the pros and cons of controlled hypotension during this surgery. Various techniques of local instillation of various drugs are discussed. RESULTSVarious drugs and techniques are compared and advantages and disadvantages of each are discussed. CONCLUSIONPremedication with various drugs, techniques of positioning and controlled hypotension are useful for control of bleeding in functional endoscopic sinus surgery.

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Hemostatic Agent Microporous Polysaccharide Hemospheres (MPH) Does Not Affect Healing or Intact Sinus Mucosa

Abstract: Absorbable hemostatic materials have starkly different effects on mucosal healing. Unlike other agents, MPH is rapidly cleared and has no negative effects on healing or intact sinus mucosa.

Cited by 52 publications

References 14 publications

Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety

Radiological and histopathological comparison of microporous polysaccharide hemospheres and oxidized regenerated cellulose in the rabbit brain: a study of efficacy and safety

Effect of Hemostatic Agent MPH® on Bleeding after Endoscopic Sinus Surgery: A Prospective Randomized Controlled Study

Anaesthetic Concerns in Functional Endoscopic Sinus Surgery

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