Activation of vocal fold healing with topical vitamin A in rabbits

Akdoğan, Özgür; Selçuk, Adın; Özcan, İbrahim; Özcan, Kürşat Murat; Giray, Seren Gülşen; Dere, Hüseyin; Özoğul, Candan

doi:10.1080/00016480802087219

Cited by 18 publications

(15 citation statements)

References 18 publications

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“…In an attempt to evaluate the potential therapeutic value of this agent during vocal fold wound healing, Akdogan et al [29] applied 0.025% topical retinoic acid gel to rabbit vocal folds at the time of injury. Histological analyses, performed 10 days post-injury for both experimental and control animals, revealed less collagen accumulation in the treatment group compared to saline-treated controls.…”

Section: Treatmentmentioning

confidence: 99%

Characterization of vocal fold scar formation, prophylaxis, and treatment using animal models

Bless

Welham

2010

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review This article reviews recent literature on animal models used to study the pathogenesis, detection, prevention and treatment of vocal fold scarring. Animal work is critical to studying vocal fold scarring because it is the only way to conduct systematic research on the biomechanical properties of the layered structure of the vocal fold lamina propria, and therefore develop reliable prevention and treatment strategies for this complex clinical problem. Recent findings During the period of review, critical anatomic, physiologic and wound healing characteristics, which may serve as the bases for selection of a certain species to help answer a specific question, have been described in mouse, rat, rabbit, ferret and canine models. A number of different strategies for prophylaxis and chronic scar treatment in animals show promise for clinical application. The pathways of scar formation and methods for quantifying treatment-induced change have become better defined. Summary Recent animal vocal fold scarring studies have enriched and confirmed earlier work indicating that restoring pliability to the scarred vocal fold mucosa is challenging but achievable. Differences between animal models and differences in outcome measurements across studies necessitate considering each study individually to obtain guidance for future research. With increased standardization of measurement techniques it may be possible to make more inter-study comparisons.

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Section: Treatmentmentioning

confidence: 99%

Characterization of vocal fold scar formation, prophylaxis, and treatment using animal models

Bless

Welham

2010

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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“…Hepatocyte growth factor was found to be important in wound healing and to stimulate hyaluronic acid production and prevent scar formation [6]. Vitamin A has been reported to prevent scar formation in the vocal fold after surgery [16]. Implanted stem cells have been shown to possess immunomodulatory and anti-inflammatory properties [17].…”

Section: Discussionmentioning

confidence: 98%

Vocal fold wound healing after injection of human adipose-derived stem cells in a rabbit model

Hong

Lee²,

Jin³

et al. 2011

Acta Oto-Laryngologica

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In comparison with the right vocal folds, there was significantly less granulation tissue in the hADSCs-injected left vocal folds (p < 0.05). Histological examination revealed excessive collagen deposition and perichondral fibrosis in the right vocal folds, whereas the left vocal folds exhibited better wound healing and less collagen deposition (p < 0.05). Among the 12 specimens injected with hADSCs, 4 specimens demonstrated viable hADSCs under immunofluorescent cytochemistry.

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“…The presence of vocal fold scars due to injury or inflammation can alter the ultrastructure of the lamina propria, disrupt the normal mucosal wave, and may result in glottic incompetence and dysphonia, affecting the quality of life. 23 24 Several substances have been used to prevent this problem and improve glottal closure, from synthetic to biological materials: Teflon, Gelfoam (Pfizer Inc., New York, NY, USA), intralesional steroids, bovine collagen, homologous collagen, muscular fascia, and fat. 23 24 25 Our study is the first to evaluate the fascia fragment integration into the lamina propria with the addition of FGFs.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Fibroblast Growth Factors in Grafted Fascia into the Vocal Fold of Rabbits

Carvalho

Júnior

Pauna

et al. 2018

Int Arch Otorhinolaryngol

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Introduction The human larynx is a very important organ for communication. Many conditions lead to scarring of the vocal folds, decreasing voice quality. Objective We aimed to determine whether fibroblast growth factors (FGFs) may influence tissue integration of grafted fascia into the vocal folds of an animal model. Methods This is an experimental animal study with 12 adult rabbits that were submitted to a grafting fragment obtained from superficial cervical fascia into the vocal fold lamina propria, bilaterally. The right vocal fold was injected with FGFs. The animals were sacrificed after 1 month or 12 months, depending on the group they were assigned to, and a histological analysis of their vocal folds was performed. We analyzed the histological changes (such as the presence of fibrosis and neovascularization) induced by the acute or chronic inflammatory reactions. Results The FGFs induced acute inflammatory changes in all animals after 1 month of the initial experiment. The presence of FGFs triggered more fibrosis than the expected due to the surgical procedure itself when compared with the control side of all animals after 12 months of the initial experiment. Conclusions Fibroblast growth factors alone do not represent a good therapeutic option in phonosurgery, since we observed higher levels of fibrosis in the vocal fold lamina propria. Further studies combining more substances may be necessary to elucidate the best option to be used in this kind of surgery.

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Activation of vocal fold healing with topical vitamin A in rabbits

Cited by 18 publications

References 18 publications

Characterization of vocal fold scar formation, prophylaxis, and treatment using animal models

Characterization of vocal fold scar formation, prophylaxis, and treatment using animal models

Vocal fold wound healing after injection of human adipose-derived stem cells in a rabbit model

The Effect of Fibroblast Growth Factors in Grafted Fascia into the Vocal Fold of Rabbits

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