In order to analyze the influence on the printing graphics from the deformation of the printing cylinders and blankets, in this paper, offset printing unit was as the research object, the three-dimensional assembly model of printing cylinders was established by using SolidWorks , the model was imported into finite element software ANSYS, by using ANSYS nonlinear contact calculated functionality, the face-to-face contact of impression surface between plate cylinder and blanket cylinder, blanket cylinder and impression cylinder were established, the stress and strain distribution of blanket were obtained, and the elongation value of circumferential and radial direction of blanket were got, the dot enlargement value was received by simulation analysis.