Paraganglioma of the urinary bladder: A clinicopathologic spectrum of a series of 14 cases emphasizing diagnostic dilemmas

Menon, Santosh; Goyal, Pankaj; Suryawanshi, Pallavi; Tongaonkar, Hemant; Joshi, Amit; Bakshi, Ganesh; Desai, Sangeeta

doi:10.4103/0377-4929.130873

Cited by 29 publications

(29 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The bladder sympathetic paraganglioma, amounting to 6% of all extra-adrenal pheochromocytomas, accounts for 0.06-0.1% of all bladder tumors (2,6). Given that it arises from sympathetic nervous system-derived chromaffin cells within the bladder wall layers, its reliable idenfication may pointed out on the basis of typical histological features and, particularly, by resorting to suitable immunohistochemical assessment in addition to specific blood plasma/urine labor tests and imaging approaches (Table 1) (2,5,7,10,13,16).…”

Section: Paragangliomas Of the Urinary Tractmentioning

confidence: 99%

“…Possible adjuvant external beam radiation the-rapy can improve median survival in patients suffering from malignant paraganglioma (1,4,6,9).…”

Section: Paragangliomas Of the Urinary Tractmentioning

confidence: 99%

“…Parasympathetic non-functional paragangliomas occur, instead, as branchiomeric and intravagal tumors, on the head and neck regions -so as tympano-jugular paraganglioma, carotid body chemosensor tumor/chemodectoma, vagal paraganglioma -without hormone production, thus their occurrence resulting found on the basis of possible tumor mass-effects symptomatology (coughing, hearing loss in one ear, swallowing difficulties) or quite incidentally during imaging examinations (1,3,6).…”

mentioning

confidence: 99%

“…About 30% of the sympathetic paragangliomas/pheochromocytomas are hereditary tumors because of mutations, under epigenetic imprinting effects, of the succinate dehydrogenase (SDH) gene whose the codified mitochondrial enzyme acts, within a proper oxygen level sensor process, to convert succinate to fumarate as a step of cell citric acid cycle (Krebs cycle) and electron transport chain, the lack of such enzyme-mediated conversion leading to send-out pseudosignals of low-oxygen environment with hypoxia like condition-induced (HIF-1α role indeed implied) abnormal cell growth/tumor promotion (3,(6)(7)(8).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Urology pertinent neuroendocrine tumors: focusing on renal pelvis, bladder, prostate located sympathetic functional paragangliomas

Alberti¹

2016

Gchir

View full text Add to dashboard Cite

About urology pertinent neuroendocrine tumors, the literature has been enriched, in the last decade, with intriguing contributions concerning the urinary tract sympathetic paragangliomas, particularly renal pelvis, bladder, prostate or periprostatic locations. ParagangliomasParagangliomas,as neuroendocrine tumors arising from embryonic neural crest cells of either sympathetic or parasympathetic paraganglia -groups of cells near nervous system-derived respective ganglia -may be of two types, functional (sympathetic chromaffin paragangliomas/pheochromocytomas), as catecholamine-secreting tumors, hence appearing with typical symptoms such as paroxysmal hypertension,heart palpitations, headache attacks, sweating or, instead, parasympathetic non-functional neoplasias as lacking in chromaffin cells (1-5).Sympathetic functional paragangliomas -outside adrenal gland chromaffin cell-derived neoplasias -are commonly found in the abdomen, within shaped paraganglia, along the aorta lenght, also including the area between renal arteries and aortic-iliac bifurcation, besides the so-called or- Chir Vol. 37 -n. 2 -pp. 55-60 March-April 2016 Urology pertinent neuroendocrine tumors: focusing on renal pelvis, bladder, prostate located sympathetic functional paragangliomas C. ALBERTI editorial article SUMMARY: Urology pertinent neuroendocrine tumors: focusing on renal pelvis, bladder, prostate located sympathetic functional paragangliomas.

show abstract

Section: Paragangliomas Of the Urinary Tractmentioning

confidence: 99%

“…Possible adjuvant external beam radiation the-rapy can improve median survival in patients suffering from malignant paraganglioma (1,4,6,9).…”

Section: Paragangliomas Of the Urinary Tractmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Urology pertinent neuroendocrine tumors: focusing on renal pelvis, bladder, prostate located sympathetic functional paragangliomas

Alberti¹

2016

Gchir

View full text Add to dashboard Cite

show abstract

“…13,22 In one particular study, a single case of distant metastasis developed 10 years after diagnosis. 17 Therefore, longer follow-up periods are recommended to determine the exact frequency of malignant PBPGs. Third, mutational analysis was not available for 1 SDHB-intact tumor that developed metastasis.…”

mentioning

confidence: 99%

Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder: A Multi-Institutional Korean Study

Park¹,

Kang²,

Kwon³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.-Because of the limited number of available primary bladder paraganglioma (PBPG) cases, the rates of succinate dehydrogenase (SDH) mutations and the clinicopathologic characteristics of SDH-deficient tumors have not been fully studied.Objective.-To define the clinicopathologic and molecular characteristics of PBPGs.Design.-A total of 52 PBPGs were collected retrospectively. SDHA and SDHB immunohistochemical stains were performed. In cases of SDHB expression loss, mutation analyses of SDHB, SDHC, and SDHD were performed.Results.-The clinicopathologic features were analyzed for 52 cases (M:F ¼ 27:25), with a mean age of 56 years (range, 22-79 years). Tumor sizes were 0.5 to 8 cm (mean, 2.4 cm). Tumor necrosis was present in 5 of 52 cases (10%), involvement of muscularis propria in 41 (79%), and lymphovascular tumor invasion in 6 (12%). During a mean follow-up period of 41 months (range, 1-161 months), 3 of 52 patients (6%) developed metastases, but no one died from the disease. Immunohistochemistry for SDHA and SDHB showed that all cases were SDHA intact. Among them, 43 cases had intact SDHB, whereas 9 cases were SDHB deficient. Compared with the SDHB-intact cases, the SDHB-deficient cases were characterized by large tumor sizes (4.5 versus 1.9 cm; P , .001), a higher number of mitoses per 10 high-powered fields (2.6 versus 0.1; P ¼ .002), and frequent lymphovascular tumor invasion (33% versus 7%; P ¼ .02) and metastases (22% versus 2%; P ¼ .02). Mutational analyses for SDHB, SDHC, and SDHD were performed in 9 SDHB-deficient cases. Among them, 6 cases were successfully sequenced and revealed SDHB mutations only.Conclusions.-Large tumor size, a higher number of mitoses, and the presence of lymphovascular tumor invasion and SDHB mutations suggest malignant paraganglioma.

show abstract

Bladder Neoplasm

Omar¹,

Khan²,

Khan³

2019

Blandy's Urology

View full text Add to dashboard Cite

Paraganglioma of the urinary bladder: A clinicopathologic spectrum of a series of 14 cases emphasizing diagnostic dilemmas

Abstract: Paraganglioma of the urinary bladder is a rare tumor and may be misdiagnosed as urothelial cancer especially on TURBT, but a high index of suspicion, careful search for the characteristic histological features and supportive immunohistochemical studies should lead to a correct diagnosis.

Cited by 29 publications

References 1 publication

Urology pertinent neuroendocrine tumors: focusing on renal pelvis, bladder, prostate located sympathetic functional paragangliomas

Urology pertinent neuroendocrine tumors: focusing on renal pelvis, bladder, prostate located sympathetic functional paragangliomas

Clinicopathologic Characteristics and Mutational Status of Succinate Dehydrogenase Genes in Paraganglioma of the Urinary Bladder: A Multi-Institutional Korean Study

Bladder Neoplasm

Contact Info

Product

Resources

About