Bladder Neoplasm

Omar, Kawa; Khan, Nawal; Khan, Muhammad Shamim

doi:10.1002/9781118863343.ch21

Cited by 2 publications

(1 citation statement)

References 145 publications

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“…Inclusion criteria included that all patients met the diagnostic criteria of the Chinese Medical Association for prostate cancer (10), all were treated surgically at our hospital, and all patients and their families were informed and signed the study information notice, which was approved by our hospital ethics committee.…”

Section: Pneumococcal Virulence and Host Immunitymentioning

confidence: 99%

Correlation analysis between CD133, Klk3 and grhl2 expression and tumor characteristics in prostate cancer

Guo

Wang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Prostate cancer is a common clinical disease in men. It is known that prostate cancer ranks 3rd in the incidence of malignant tumors of the male genitourinary system in China, which is able to evaluate the riskiness of life expectancy of male patients. Therefore, we investigated the expression of CD133, recombinant human kallikrein 3 (Klk3), grainy head like 2 (grhl2) in prostate cancer, and correlation with tumor characteristics in the present study. A total of 167 prostate cancer patients who underwent surgical treatment in our hospital from February 2017 to April 2021 were selected. Their cancer and adjacent tissues were resected, and CD133 was detected by double staining using immunohistochemistry, Klk3 and grhl2 were detected by RT-PCR analysis, and CD133, Klk3 were analyzed by Pearson's method in different clinical stages, Gleason grade Correlation of grhl2 with tumor characteristics. The expression of CD133, KLK3, and GRHL2 in cancer tissue was increased compared with adjacent tissue (P < 0.05). The expression of CD133, KLK3, and GRHL2 increased with the aggravation of the clinical stage and Gleason grade (P < 0.05). CD133, KLK3, and GRHL2 showed a positive correlation in prostate cancer. The Pearson method found a positive correlation between CD133, KLK3, GRHL2 and clinical stage, Gleason grade, and lymph node metastasis. In general, high CD133, Klk3, and grhl2 expression was observed in prostate cancer and increased with the disease. They presented a positive correlation in prostate cancer presence, and these three gene products correlated with tumor characteristics.

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Section: Pneumococcal Virulence and Host Immunitymentioning

confidence: 99%

Correlation analysis between CD133, Klk3 and grhl2 expression and tumor characteristics in prostate cancer

Guo

Wang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Metabolomic profiling of human bladder tissue extracts

Ossoliński,

Ruman,

Copié

et al. 2024

Metabolomics

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IntroductionBladder cancer is a common malignancy affecting the urinary tract and effective biomarkers and for which monitoring therapeutic interventions have yet to be identi ed. ObjectivesMajor aim of this work was to perform metabolomic pro ling of human bladder cancer and normal tissue and to evaluate cancer biomarkers Methods This study utilized nuclear magnetic resonance (NMR) and high-resolution nanoparticle-based laser desorption/ionization mass spectrometry (LDI-MS) methods to investigate polar metabolite pro les in tissue samples from 99 bladder cancer patients. ResultsThrough NMR spectroscopy, six tissue metabolites were identi ed and quanti ed as potential indicators of bladder cancer, while LDI-MS allowed detection of 34 compounds which distinguished cancer tissue samples from normal tissue. Thirteen characteristic tissue metabolites were also found to differentiate bladder cancer tumor grades and thirteen metabolites were correlated with tumor stages. Receiver-Operating Characteristics analysis showed high predictive power for all three types of metabolomics data, with area under the curve (AUC) values greater than 0.853. ConclusionTo date, this is the rst study in which human normal tissues adjacent to cancerous tissues are analyzed. These ndings suggest that the metabolite markers identi ed in this study may be useful for the detection and monitoring of bladder cancer stages and grades.

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Bladder Neoplasm

Cited by 2 publications

References 145 publications

Correlation analysis between CD133, Klk3 and grhl2 expression and tumor characteristics in prostate cancer

Correlation analysis between CD133, Klk3 and grhl2 expression and tumor characteristics in prostate cancer

Metabolomic profiling of human bladder tissue extracts

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