Paracrine communication in the anterior pituitary as studied in reaggregate cell cultures

Vankelecom, Hugo; Denef, Carl

doi:10.1002/(sici)1097-0029(19971015)39:2<150::aid-jemt6>3.0.co;2-p

Cited by 38 publications

(15 citation statements)

References 49 publications

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“…Endocrine cells are capable of synthesizing and secreting myriad substances which diffuse locally to elicit effects upon target cells; as such, paracrine and autocrine signaling comprise arguably the most diverse intercellular communication pathway within the pituitary (Denef, 2008;Vankelecom and Denef, 1997). Paracrine and autocrine molecules are not limited to peptides, but can also encompass nucleotides (e.g.…”

Section: Intrapituitary Regulation Of Endocrine Cell Network Functionmentioning

confidence: 99%

Anterior pituitary cell networks

Tissier

Hodson

Lafont

et al. 2012

Frontiers in Neuroendocrinology

125

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Both endocrine and non-endocrine cells of the pituitary gland are organized into structural and functional networks which are formed during embryonic development but which may be modified throughout life. Structural mapping of the various endocrine cell types has highlighted the existence of distinct network motifs and relationships with the vasculature which may relate to temporal differences in their output. Functional characterization of the network activity of growth hormone and prolactin cells has revealed a role for cell organization in gene regulation, the plasticity of pituitary hormone output and remarkably the ability to memorize altered demand. As such, the description of these endocrine cell networks alters the concept of the pituitary from a gland which simply responds to external regulation to that of an oscillator which may memorize information and constantly adapt its coordinated networks' responses to the flow of hypothalamic inputs.

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Section: Intrapituitary Regulation Of Endocrine Cell Network Functionmentioning

confidence: 99%

Anterior pituitary cell networks

Tissier

Hodson

Lafont

et al. 2012

Frontiers in Neuroendocrinology

125

View full text Add to dashboard Cite

show abstract

“…The functions of hormone-producing cells are mainly regulated by endocrine, autocrine, and paracrine signaling. In addition to this humoral regulation, their functions are believed to be modified by juxtacrine signaling, by which cells receive components of the plasma membrane from adjacent cells as signals (Vankelecom & Denef 1997), and matricrine signaling, by which cells receive components of the ECM as a signal (Paez-Pereda et al 2005).…”

Section: Introductionmentioning

confidence: 99%

“…The existence of S100b-GFP rats allows us to distinguish living FS cells and to separate them from the hormone-producing cells. Cell-to-cell interactions between FS cells and between FS cells and hormone-producing cells have been studied and described by several research groups (Rinehart & Farquhar 1953, Vankelecom & Denef 1997, John et al 2004. However, by utilizing S100b-GFP rats, we are now able to develop new approaches to investigate these interactions.…”

Section: Introductionmentioning

confidence: 99%

Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells

Horiguchi¹,

Kikuchi²,

Kusumoto³

et al. 2009

Journal of Endocrinology

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Folliculo-stellate (FS) cells in the anterior pituitary gland appear to possess multifunctional properties. Recently, the development of transgenic rats (S100b-green fluorescent protein (GFP) rats) that express GFP specifically in FS cells in the anterior pituitary gland has allowed us to distinguish and observe living FS cells in other kinds of pituitary cells. We used S100b-GFP rats to investigate the topographic affinity of FS cells for other pituitary cells. We observed living FS cells in enzymatically dispersed anterior pituitary cells of S100b-GFP rats under a fluorescent microscope, and noted that FS cells markedly extended and contracted cytoplasmic processes and formed interconnections with neighboring FS cells. In addition, FS cells adhered to small clusters of GFPnegative cells, which were primarily hormone-producing cells, and these clusters further aggregated during the course of cytoplasmic contraction. In the presence of laminin, fibronectin, and varying types of collagen, FS cells showed marked changes in shape and specific proliferative activity; however, GFP-negative cells did not. On reverse transcription-PCR analysis and immunohistochemistry, FS cells were shown to express integrin subunits, which are the cell surface receptors for extracellular matrix (ECM). In the anterior pituitary gland, FS cells and the various types of hormoneproducing cells generate a unique topography in the presence of basement membrane components and interstitial collagens. The novel characteristics of FS cells observed in the present study suggest that in the anterior pituitary gland, FS cells play important roles in determining and/or maintaining local cellular arrangement in the presence of ECM components.

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“…Although FS cells do not produce any pituitary hormones, their special tendency to surround endocrine cells with their long cytoplasmic processes suggests that they regulate endocrine cells by intracellular communication. It has been documented that paracrine communication plays an important role, not only in the regulation of hormone secretion, but also in the development, growth, differentiation and possibly also vasculaturity of the anterior pituitary (49,50). The origin and differentiation of FS cells, particularly the possibility that FS cells are stem cells which have the potential to differentiate into endocrine cells, has also been suggested (48).…”

Section: Angiogenesis and Neoplasms Of Endocrine Glandsmentioning

confidence: 99%

Angiogenesis of endocrine gland tumours--new molecular targets in diagnostics and therapy

Stępień

Kołomecki²,

Pasieka³

et al. 2002

European Journal of Endocrinology

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Angiogenesis is one of the key stages in the development of neoplastic tumours, in which a small group of mutated cells transforms into a large malignant tumour metastasising to the neighbouring tissues and organs. The studies on the significance of neoangiogenesis in the progression of endocrine gland neoplasms have recently become one of the most rapidly evolving branches of molecular endocrinology. The induction of angiogenesis has been demonstrated to result from the imbalance between positive and negative factors which control this process. Our paper presents the results of current studies on the role of factors such as molecular markers of angiogenesis (e.g. vascular endothelial growth factor and basic fibroblast growth factor), metalloproteinases (which regulate the decomposition of the extracellular matrix) and their inhibitors, and adhesive molecules (e.g. soluble vascular cellular adhesion molecule-1 and soluble intracellular adhesion molecule-1) in the pathogenesis and diagnostics of endocrine gland tumours in humans. Also, we discuss new therapeutic strategies for inhibiting the growth of neoplasms by blocking the formation of blood vessels using angiogenesis antagonists, which inhibit various stages of angiogenesis. More and more data are being accumulated suggesting that these preparations could, in the near future, be used in the pharmacotherapy of some endocrine gland neoplasms.

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Paracrine communication in the anterior pituitary as studied in reaggregate cell cultures

Cited by 38 publications

References 49 publications

Anterior pituitary cell networks

Anterior pituitary cell networks

Living-cell imaging of transgenic rat anterior pituitary cells in primary culture reveals novel characteristics of folliculo-stellate cells

Angiogenesis of endocrine gland tumours--new molecular targets in diagnostics and therapy

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