Papillomavirus Infection: Principle Characteristics, Clinical Manifestations, Vaccine Prophylaxis

Lopukhov, Platon D; Брико, Н. И.; Khaldin, A. A.; Tsapkova, N. N.; Лупашко, О В

doi:10.36233/0372-9311-2016-1-71-78

Journal of microbiology, epidemiology and immunobiology

2016

DOI: 10.36233/0372-9311-2016-1-71-78

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Papillomavirus Infection: Principle Characteristics, Clinical Manifestations, Vaccine Prophylaxis

Platon D Lopukhov

Н. И. Брико

A. A. Khaldin

et al.

Abstract: Papillomaviruses are a large and diverse group of viruses. It includes approximately 200 fully described types that have been detected in humans. Human papilloma viruses (HPV) are etiologic agents during various benign and malignant lesions of mucous membrane and skin epithelium. Very importantly, persistent HPV infection of certain types is a leading cause of carcinoma of uterine cervix, penis, vulva, vagina, anal canal and fauces (including tongue base and tonsils). HPV infection prophylaxis is the best mean… Show more

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Cited by 3 publications

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“…The IHC for HPV performed in this case was also negative. However, the antibody we used (Dako, monoclonal mouse, anti-HPV, clone K1H8) can only effectively detect 11 out of more than 200 types of HPV 3 , so PCR and genotyping from the National Microbiology Lab of Canada was requested, and the result is negative.…”

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Esophageal Squamous Papilloma in a Pediatric Patient With Helicobacter pylori Gastritis

et al. 2017

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confidence: 99%

Esophageal Squamous Papilloma in a Pediatric Patient With Helicobacter pylori Gastritis

et al. 2017

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“…(In Russian) DOI: http://doi.org/10.35627/2219-5238/2020-324-3-44-47 Information about the authors: Brusnigina N.F., https://orcid.org/0000-0003-4582-5623; Makhova M.A., https://orcid.org/ 0000-0002-9443-0030; Chernevskaya O.M., https://orcid.org/0000-0001-7523-7035; Orlova K.A., https://orcid.org/0000-0001-9104-7119; Kolesnikova E.A., https://orcid.org/0000-0002-0859-4339; Barysheva N.N., https://orcid.org/0000-0003-3821-3610; Nikiforova E.S., https://orcid.org/0000-0002-3390-3236; Smetanina S.V., https://orcid.org/0000-0002-7000-5910. [5,8,9].…”

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Detection Rates of Human Papillomavirus Associated with Cervical Cancer in Women of Nizhny Novgorod

Бруснигина¹,

Махова²,

Черневская³

et al. 2020

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The purpose of the study was to assess detection rates of human papillomavirus in cervical cancer cases of Nizhny Novgorod. Materials and methods. We used the real-time polymerase chain reaction (PCR) to test samples of mucosa lining of the cervical canal and/or transformation zone taken from 630 women with cervical dysplasia of different degrees and 107 incident cases of cervical cancer that did not undergo treatment. The detection and differentiation of 14 genotypes of high-risk human papillomaviruses (HPV) was carried out using the AmpliSens® HPV HCR-genotype-FRT PRC kit. Results. The overall infection rate of women with oncogenic human papillomaviruses was 41.8%. Among the genotypes, HPV 16 (39.2%), 18 (15.5%), 33 (16.6%), and 56 (11.9%) predominated. A high prevalence of oncogenic HPV was detected in the women with cervical intraepithelial neoplasia (58.1%) and cervical cancer (90%). The spectrum of genotypes in women with neoplasia of various degrees differed. In women with CIN II and CIN III, vaccine-preventable HPV genotypes (HPV 16 and 18) playing the leading role in the development of cervical cancer were the most frequent. The same genotypes dominated in the women with invasive cervical cancer. One oncogenic HPV genotype was usually found in the infected women (69%). The high-risk HPV infection was often combined with Ureaplasma ssp (49.3%), Mycoplasma hominis (20.1%), Cytomegalovirus (21.1%), and Herpes simplex I/II (18.2%) infections. Combinations of high-risk HPV with Chlamydia trachomatis and Herpes 6 were found in 8.3% and 5% of the cases, respectively. Conclusions. Our findings proved a wide prevalence of high carcinogenic risk HPV 16 and 18 genotypes, thus indicating the expediency of using Cervarix and Gardasil vaccines registered in the Russian Federation and containing antigens to these types of virus for specific prevention of the HPV infection.

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Clinical and epidemiological characteristics of cancers associated with human papillomavirus in the regions of North-West Russia

Lyalina

Kholopov

Yazenok³

et al. 2023

Journal of microbiology, epidemiology and immunobiology

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Introduction. The leading role of the human papillomavirus in the etiopathogenesis of malignant neoplasms of some localizations is generally recognized. Vaccines that are used in the world and in Russia for the prevention of papillomavirus infection create the basis for the elimination of diseases associated with the human papillomavirus in the future. The aim of the study is to determine the regional, gender and age-specific features of cancers associated with the human papillomavirus to substantiate the development of a unified system of epidemiological surveillance and vaccination. Materials and methods. The retrospective epidemiological analysis of the incidence of cancers associated with the human papillomavirus and mortality due to these neoplasms in the regions of the North-Western Federal District of Russia in 20112020 was carried out based on data from Statistic Form 7 "Information on malignant neoplasms" and the Population cancer Registers of St. Petersburg (13,117 cases), Leningrad region (3204 cases) and the Kaliningrad region (2898 cases). Results. In the structure of cancers associated with the human papillomavirus in St. Petersburg, Leningrad and Kaliningrad regions, more than 90% of men had tumors of the oral cavity, oropharynx and larynx, more than 60% of women had cervical cancer. Regional and age-specific features of the incidence of cervical cancer and mortality from this pathology have been established. Statistically significant differences in the incidence of cancer of the head and neck, anus and anal canal in different age groups of the male and female population were revealed. Conclusion. As a result of the study, regional, gender and age-specific features of the incidence of human papillomavirus-associated malignant neoplasms in the North-West of Russia were established. These data should be used to develop a system of epidemiological surveillance of papillomavirus infection and vaccination program.

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Papillomavirus Infection: Principle Characteristics, Clinical Manifestations, Vaccine Prophylaxis

Cited by 3 publications

References 25 publications

Esophageal Squamous Papilloma in a Pediatric Patient With Helicobacter pylori Gastritis

Esophageal Squamous Papilloma in a Pediatric Patient With Helicobacter pylori Gastritis

Detection Rates of Human Papillomavirus Associated with Cervical Cancer in Women of Nizhny Novgorod

Clinical and epidemiological characteristics of cancers associated with human papillomavirus in the regions of North-West Russia

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