Papillary Carcinoma of the Thyroid with Distant Metastases to the Cerebrum: a Case Report

Ota, Tsuguhito; Bando, Yoshiaki; Hirai, Masamichi; Tanaka, Nobuyoshi; Takabatake, Yasushi; Kasahara, Yoshio; Fujisawa, Masakiyo

doi:10.1093/jjco/hye023

Cited by 28 publications

(25 citation statements)

References 14 publications

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“…Cerebellar metastases are even less common. Only 12 cases of metastatic changes in the cerebrum from DTC were reported in the literature, some of them occurring as solitary distant metastasis [2,3,[13][14][15][16][17]. The metastatic lesion in our patient was not solitary.…”

Section: Opis Przypadkumentioning

confidence: 61%

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Przerzut do móżdżku raka brodawkowatego tarczycy wykryty w scyntygrafii receptorów somatostatynowych

Czepczyński

Wyszomirska

Gryczyńska

et al. 2018

Endokrynologia Polska

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Introduction: Distant metastases of papillary thyroid carcinoma (PTC) may lack the ability to concentrate radioiodine. In such cases, positive somatostatin receptor scintigraphy might be useful in demonstrating the expression of somatostatin receptors that are potential therapeutic targets. To date, only a few cerebellar metastases from PTC have been reported in the literature. Patient findings:We present an 82-year-old female, in whom an asymptomatic cerebellar metastasis from PTC was diagnosed by means of Tc-99m-EDDA/HYNIC-TOC scintigraphy four years after the initial diagnosis. She was previously treated with total thyroidectomy and regional lymph node dissection, followed by three cycles of radioiodine therapy. Despite persistently elevated thyroglobulin, no specific radioiodine accumulation was found in the whole body post-treatment scan. Tc-99m-EDDA/HYNIC-TOC scintiscan revealed foci of increased tracer uptake in the lungs, cervical lymph nodes, and a single focus in the head. Thus, therapy with octreotide LAR was initiated. The patient died four months later due to disseminated PTC. Summary: In this paper, a patient with asymptomatic previously unknown non-iodine avid cerebellar metastasis of PTC diagnosed by means of scintigraphy using somatostatin analogue Tc-99m-EDDA/HYNIC-TOC is reported. Conclusions: Somatostatin receptor scintigraphy might be useful in the visualisation of non-iodine avid PTC metastases and demonstrating the expression of somatostatin receptors that are potential therapeutic targets. (Endokrynol Pol 2018; 69 (1): 24-27)

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Section: Opis Przypadkumentioning

confidence: 61%

“…In some patients, the metastases were detected in cases of occult thyroid carcinoma [12,13]. Cerebellar metastases are even less common.…”

Section: Opis Przypadkumentioning

confidence: 99%

Przerzut do móżdżku raka brodawkowatego tarczycy wykryty w scyntygrafii receptorów somatostatynowych

Czepczyński

Wyszomirska

Gryczyńska

et al. 2018

Endokrynologia Polska

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“…Papillary thyroid carcinoma has commonly a relatively less aggressive clinical course and thus behaves unlike other thyroid cancers [5]. The prognosis is usually excellent and the reported survival rates for non-metastatic lesions are 97.8% at 5 years and 94.9% at 10 years [6].…”

Section: Discussionmentioning

confidence: 99%

Calvarial metastasis from papillary thyroid carcinoma: A case report

Bozkurt¹,

Ozdemir²,

Percinel³

et al. 2013

Pau Med J

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A large variety of metastatic tumors can be found in the skull; breast, prostate, lung carcinoma, multiple myeloma, neuroblastoma and sarcoma are among those that have been reported in the literature. In the current case, a very rare case of metastasis to skull from papillary thyroid carcinoma is reported. A 45-year-old man was admitted to our service with head trauma. Computed tomography and magnetic resonance imaging revealed lytic mass lesions in the right frontal and occipital bone extending through the dura mater and subcutaneous tissue. Right frontal, suboccipital craniectomy, tumor excision were performed and microscopic examination revealed papillary thyroid carcinoma metastasis. There is no consensus on treatment protocols for patients with central nervous system metastases from papillary thyroid carcinoma, most likely because of the rarity of cases. In the present case, we suggest that the best option for treatment of papillary thyroid carcinoma metastasis to skull would be surgery followed by radiotherapy. Pam Med J 2013;6(2):104-106Key words: Brain tumors, Craniotomy, Metastasis, Papillary Thyroid Carcinoma ÖzetKranial bölgeye bir çok farklı tümör metastaz yapabilmektedir; bunlar içerisinde meme, prostat, akciğer kanseri, multipl myeloma, nöroblastoma ve sarkoma sayılabilir. Bu yazıda çok nadir görülen papiller tiroid karsinomunun kraninuma metastazı sunulacaktır. 45 yaşında erkek hasta kafa travması şikayeti ile kliniğimize başvurdu. Çekilen kranial tomografi ve magnetik rezonans incelemelerinde sağ frontal ve oksipital kemikte dura mater ve subkutanöz dokulara uzanım gösteren litik kitle lezyonları tespit edildi. Çok nadir görülmesi nedeni ile papiller tiroid karsinomunun santral sinir sistemi metastazının tedavisi ile ilgili literatürde net bir tedavi şeması bulunmamaktadır. Bu yazı ile papiller tiroid karsinomunun kranial metastazında en uygun tedavi yönteminin cerrahi rezeksiyon ve ardından radyoterapi uygulaması şeklinde olduğu belirtilmiştir.

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“…Patients with recurrent disease outside the neck structures usually show lung micrometastases or bone infiltrations [5]. Brain metastases (BMs) from TC, however, are quite rare, involving only 0.5-2.3% of all DTC cases [6][7][8][9][10][11][12]. Prognosis is usually poor due to its high morbidity and mortality rates.…”

Section: Introductionmentioning

confidence: 99%

Thyroid Cancer Brain Metastases and Thyroglobulin

et al. 2016

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Background: Thyroid cancer (TC) is the most common endocrine cancer. The majority of patients reach long survival rates, but 10-15% of patients show recurrent disease, and 5% have distant metastases. Brain metastases (BMs) from TC are rare and carry high morbidity and mortality.Methods: From January 2010 to December 2015, nearly 400 patients with TC were treated at a tertiary referral center. This study reports the findings of all seven patients with BM, which were compared to historical controls.Results: Male patients and older age are associated with a higher frequency of distant metastases from TC. Among patients with BM, surgical excision when indicated, followed by whole brain radiotherapy, was the treatment associated with longest survival rates. Conclusion:Thyroglobulin was the most useful serum marker to diagnose recurrence or distant disease. High levels of thyroglobulin (mean: 15,029; IQR: 300 -13,687) were mainly associated with BMs.

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Papillary Carcinoma of the Thyroid with Distant Metastases to the Cerebrum: a Case Report

Cited by 28 publications

References 14 publications

Przerzut do móżdżku raka brodawkowatego tarczycy wykryty w scyntygrafii receptorów somatostatynowych

Przerzut do móżdżku raka brodawkowatego tarczycy wykryty w scyntygrafii receptorów somatostatynowych

Calvarial metastasis from papillary thyroid carcinoma: A case report

Thyroid Cancer Brain Metastases and Thyroglobulin

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