This paper presents a statistical method of single-channel speech enhancement that uses a variational autoencoder (VAE) as a prior distribution on clean speech. A standard approach to speech enhancement is to train a deep neural network (DNN) to take noisy speech as input and output clean speech. Although this supervised approach requires a very large amount of pair data for training, it is not robust against unknown environments. Another approach is to use nonnegative matrix factorization (NMF) based on basis spectra trained on clean speech in advance and those adapted to noise on the fly. This semi-supervised approach, however, causes considerable signal distortion in enhanced speech due to the unrealistic assumption that speech spectrograms are linear combinations of the basis spectra. Replacing the poor linear generative model of clean speech in NMF with a VAE-a powerful nonlinear deep generative modeltrained on clean speech, we formulate a unified probabilistic generative model of noisy speech. Given noisy speech as observed data, we can sample clean speech from its posterior distribution. The proposed method outperformed the conventional DNN-based method in unseen noisy environments.

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This paper describes a computationally-efficient blind source separation (BSS) method based on the independence, lowrankness, and directivity of the sources. A typical approach to BSS is unsupervised learning of a probabilistic model that consists of a source model representing the time-frequency structure of source images and a spatial model representing their interchannel covariance structure. Building upon the low-rank source model based on nonnegative matrix factorization (NMF), which has been considered to be effective for inter-frequency source alignment, multichannel NMF (MNMF) assumes source images to follow multivariate complex Gaussian distributions with unconstrained full-rank spatial covariance matrices (SCMs). An effective way of reducing the computational cost and initialization sensitivity of MNMF is to restrict the degree of freedom of SCMs. While a variant of MNMF called independent low-rank matrix analysis (ILRMA) severely restricts SCMs to rank-1 matrices under an idealized condition that only directional and lessechoic sources exist, we restrict SCMs to jointly-diagonalizable yet full-rank matrices in a frequency-wise manner, resulting in FastMNMF1. To help inter-frequency source alignment, we then propose FastMNMF2 that shares the directional feature of each source over all frequency bins. To explicitly consider the directivity or diffuseness of each source, we also propose rankconstrained FastMNMF that enables us to individually specify the ranks of SCMs. Our experiments showed the superiority of FastMNMF over MNMF and ILRMA in speech separation and the effectiveness of the rank constraint in speech enhancement.

In search and rescue activities, unmanned aerial vehicles (UAV) should exploit sound information to compensate for poor visual information. This paper describes the design and implementation of a UAV-embedded microphone array system for sound source localization in outdoor environments. Four critical development problems included water-resistance of the microphone array, efficiency in assembling, reliability of wireless communication, and sufficiency of visualization tools for operators. To solve these problems, we developed a spherical microphone array system (SMAS) consisting of a microphone array, a stable wireless network communication system, and intuitive visualization tools. The performance of SMAS was evaluated with simulated data and a demonstration in the field. Results confirmed that the SMAS provides highly accurate localization, water resistance, prompt assembly, stable wireless communication, and intuitive information for observers and operators.

Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of chronic liver injury. NAFLD includes a wide range of clinical conditions from simple steatosis to nonalcoholic steatohepatitis (NASH), advanced fibrosis, and liver cirrhosis. The histological findings of NASH indicate hepatic steatosis and inflammation with characteristic hepatocyte injury (e.g., ballooning degeneration), as is observed in the patients with alcoholic liver disease. NASH is considered to be a potentially health-threatening disease that can progress to cirrhosis. A liver biopsy remains the most reliable diagnostic method to appropriately diagnose NASH, evaluate the severity of liver fibrosis, and determine the prognosis and optimal treatment. However, this invasive technique is associated with several limitations in routine use, and a number of biomarkers have been developed in order to predict the degree of liver fibrosis. In the present article, we review the current status of noninvasive biomarkers available to estimate liver fibrosis in the patients with NASH. We also discuss our recent findings on the use of the glycated albumin-to-glycated hemoglobin ratio, which is a new index that correlates to various chronic liver diseases, including NASH.