Przerzut do móżdżku raka brodawkowatego tarczycy wykryty w scyntygrafii receptorów somatostatynowych

Czepczyński, Rafał; Wyszomirska, Anna; Gryczyńska, Maria; Szczepanek‐Parulska, Ewelina; Ruchała, Marek

doi:10.5603/ep.a2018.0009

Cited by 5 publications

(3 citation statements)

References 18 publications

(25 reference statements)

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“…The majority of the RDMs were identified post-operatively, while they were scarcely ever identified pre-operatively. It has been shown that among 1200 thyroid carcinoma patients treated in Czepczynski R's institution, fewer than 1% had distant metastases detected at the time of the initial diagnosis (25). Of note, a literature review by Davidson M showed that almost all PTC's pancreatic metastases were post-operatively identified (26).…”

Section: Discussionmentioning

confidence: 99%

Multiple Simultaneous Rare Distant Metastases as the Initial Presentation of Papillary Thyroid Carcinoma: A Case Report

Yang

Gong

et al. 2019

Front. Endocrinol.

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Papillary thyroid carcinoma (PTC) commonly metastasizes to regional lymph nodes. However, they infrequently cause rare distant metastases (RDMs), with the exclusion of lungs and bone metastases. RDMs are seldom identified prior to a primary thyroid cancer diagnosis. Therefore, cases initially presenting with synchronously multiple RDMs from PTC are extremely infrequent. This is a rare case of a 48-year-old man with initial diaphragm, pancreatic, and liver tumors from PTC. Following resection of the tumors, an ultrasound-guided fine-needle aspiration (US-FNA) cytology of a mass in the thyroid's left lobe revealed PTC. After postoperative recovery for more than 4 months, physical examination identified an irregular large nodule in the thyroid's isthmus and left lobe, a swollen lymph node in the left neck, and a mass in the right parotid gland. Ultrasound reexamination revealed numerous hypoechoic masses as follows: one in the thyroid's isthmus and entire left lobe (7.3 × 5.9 × 5.1 cm) and multiple in the thyroid's right lobe (0.2–0.3 cm). Ultrasound examination also showed several swollen lymph nodes in the left neck, a mass in the left gluteus maximus, and several masses in both the bilateral parotid and salivary region. The US-FNA's pathological examination confirmed metastatic PTCs in the left gluteus maximus and bilaterally located in the parotid and salivary gland. 18-fluorodeoxyglucose positron-emission tomography and computed tomography scan revealed abnormal uptakes in numerous locations (e.g., the thyroid's isthmus and left lobe, bilateral parotid gland, subcutaneous tissues, etc.). The patient underwent palliative therapy, including total thyroidectomy, bilateral central neck dissection, left lateral neck dissection, and excision of the bilateral parotid and salivary gland. A whole-body scan post-therapeutic radioactive iodine ablation showed exclusive thyroid bed uptake. Subsequently, the patient underwent continuous thyroid stimulating hormone repression therapy and was treated with lenvatinib chemotherapy for ~8 months. The primary thyroid tumor, pancreatic metastasis, and cervical lymph node metastasis were both positive for BRAFV600E and TERT promoter (C288T) mutations. After 13 months of follow-up, the patient is currently in stable clinical conditions. In conclusion, the present case is an extremely rare occurrence of simultaneous multiple RDMs from PTC as the initial presentation.

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Section: Discussionmentioning

confidence: 99%

Multiple Simultaneous Rare Distant Metastases as the Initial Presentation of Papillary Thyroid Carcinoma: A Case Report

Yang

Gong

et al. 2019

Front. Endocrinol.

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“…Moreover, the use of pasireotide in combination with everolimus, an mTOR inhibitor, is proposed with improved therapeutic values in selective thyroid tumours [ 456 ]. It is also worth mentioning here that SSTR scintigraphy has been used to detect cerebellar metastasis of PTC [ 457 ]. Although controversies exist, the role of SST and its analogues in thyroid tumour diagnosis and prognosis cannot be denied in a receptor and tumour-specific manner.…”

Section: Somatostatin Receptors and Thyroid Cancermentioning

confidence: 99%

Somatostatin and Somatostatin Receptors in Tumour Biology

Kumar

2023

IJMS

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Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release from secretory or immune cells, the first most appreciated role that SST exhibits is the antiproliferative effect in target tissue that served as a potential therapeutic intervention in various tumours of different origins. The SST-mediated in vivo and/or in vitro antiproliferative effect in the tumour is considered direct via activation of five different somatostatin receptor subtypes (SSTR1-5), which are well expressed in most tumours and often more than one receptor in a single cell. Second, the indirect effect is associated with the regulation of growth factors. SSTR subtypes are crucial in tumour diagnosis and prognosis. In this review, with the recent development of new SST analogues and receptor-specific agonists with emerging functional consequences of signaling pathways are promising therapeutic avenues in tumours of different origins that are discussed.

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“…Conversely, in the case of non-iodine avid metastases, false-negative results are observed. In these rare situations, different techniques such as 18F-FDG PET/CT or somatostatin receptor scintigraphy may be helpful [15].…”

Section: Opis Przypadkumentioning

confidence: 99%

False-positive radioiodine whole-body scan due to a renal cyst

Maciejewski

Czepczyński

Ruchała

2018

Endokrynologia Polska

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Patients affected by differentiated thyroid cancer are treated surgically and by ablative radioiodine therapy. A post-therapy whole-body scan allows detection of thyroid remnants or local and distant metastases, although false-positive findings may be observed. We report a case of a 75-year-old woman with follicular thyroid cancer, who underwent ablative radioiodine treatment. On post-therapy wholebody scan, abnormal uptake in the left upper abdomen was found, although stimulated thyroglobulin level was not suggestive for distant metastases of differentiated thyroid carcinoma. Additional SPECT/CT acquisition revealed focal 131 I uptake located at the posterolateral wall of the left kidney corresponding to a round lesion 47 mm in maximal diameter. In order to verify this finding abdominal ultrasound and abdominal contrast-enhanced CT were performed, confirming multiple renal cysts in the left kidney; the largest one was the site of abnormal radioiodine accumulation. Despite the high incidence of renal cysts, especially in the elderly, radioiodine uptake in renal cysts is extremely rare. Different hypotheses on the mechanism of radioiodine uptake in the cyst were proposed, among them active secretion by sodium-iodide symporter or other transporting proteins. We conclude that abnormal radioiodine uptake in renal cysts can be an exceptional finding mimicking a metastasis.

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Przerzut do móżdżku raka brodawkowatego tarczycy wykryty w scyntygrafii receptorów somatostatynowych

Cited by 5 publications

References 18 publications

Multiple Simultaneous Rare Distant Metastases as the Initial Presentation of Papillary Thyroid Carcinoma: A Case Report

Multiple Simultaneous Rare Distant Metastases as the Initial Presentation of Papillary Thyroid Carcinoma: A Case Report

Somatostatin and Somatostatin Receptors in Tumour Biology

False-positive radioiodine whole-body scan due to a renal cyst

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