Paper based point-of-care testing disc for multiplex whole cell bacteria analysis

Li, Chen Zhong; Vandenberg, Katherine; Prabhulkar, Shradha; Zhu, Xuena; Schneper, Lisa; Methee, Kalai; Rosser, Charles J.; Almeide, Eugenio

doi:10.1016/j.bios.2011.04.035

Cited by 192 publications

(93 citation statements)

References 31 publications

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“…1.2c), adopting folding techniques [119] and microplate paper platforms [120]. NP-based detection has been demonstrated with metabolites [109,111,113,117,121,147], bacterial agents [112] in disease diagnosis such as HIV [119], malaria [115], tuberculosis [120] and in environmental monitoring [114,118]. To multiplex the assay, monodisperse latex can be coupled with fluorescent and coloured dyes, and para/magnetic components.…”

Section: Colloidal Nanoparticles (Nps)mentioning

confidence: 99%

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Point-of-Care Diagnostics

Yetisen

2014

Holographic Sensors

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Rapid tests that are low-cost and portable are the first line of defence in healthcare systems. Dipstick and lateral-flow are the two universal assay formats as they are lightweight and compact, and provide qualitative results without external instrumentation. However, existing formats have limitations in the quantification of analyte concentrations. Hence, the demand for sample preparation, improved sensitivity and user-interface has challenged the commercial products. Recently, capabilities, sensors and readout devices were expanded to multiplexable assays platforms, which might transcend the capabilities of existing design format of diagnostic tests. This chapter outlines the evolution of diagnostic devices and current trends in the development of qualitative and quantitative sensing devices for applications in healthcare, veterinary medicine, environmental monitoring and food safety. The chapter also discusses design parameters for diagnostics, their functionalisation to increase the capabilities and the performance, emerging sensing platforms and readout technologies. The factors which limit the emerging rapid diagnostics to become commercial products are also discussed.The life expectancy has grown worldwide, which also increased the healthcare spending [1, 2]. For example, 720 million people will be aged 65 or older by 2020. Currently four in five people over the age of 75 take at least one prescribed medicine, and this trend is set to increase [3]. For some of the medications, large pharma find it the hard to recover R&D costs while the pressure from the regulatory agencies also increased for the use of new drugs as the first line of defence based on efficacy and cost. Hence, the global healthcare trends and ever increasing pressure from regulatory agencies put a strong case for the development of diagnostics for healthcare monitoring as well as the evaluation of drug efficacies in clinical trials. All these considerations parallels governments' and insurance companies' interests in obtaining the best performance possible and treatment benefits they support. These trends are behind the driving force for the development of diagnostics that can reduce the healthcare costs by developing effective drugs and identifying diseases and conditions at an early stage.The major stumbling block in monitoring and controlling diseases/contaminations remains delivering simple, low-cost and robust diagnostic tests [4,5]. In the developing world, the basic healthcare infrastructure and trained healthcare personnel are

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Section: Colloidal Nanoparticles (Nps)mentioning

confidence: 99%

“…These devices were demonstrated by using porous materials such as nitrocellulose and cellulose depending on the sensing application. Other 2D paper networks involved integrating the inlets of a number of lateral flow assays [112] (Fig. 1.2c), adopting folding techniques [119] and microplate paper platforms [120].…”

Section: Colloidal Nanoparticles (Nps)mentioning

confidence: 99%

Point-of-Care Diagnostics

Yetisen

2014

Holographic Sensors

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“…[1][2][3][4][5][6][7][8][9] Among them, paper-based POC devices are a special category due to the advantages of being simple, rapid, on-site, and cost-effective; they have been widely used in home health care and medical testing, [10][11][12] even environmental monitoring. [13][14][15] The lateral flow immunochromatographic assay, also called lateral flow test, is one of the simplest and most popular formats of paper-based POC devices and can be used to detect specific substances, including small molecules, [15][16][17][18] large proteins, [19][20][21] and even whole pathogens, 10 in a sample by using an immunological reaction. However, most of these tests are based on qualitative colorimetry, which is not sufficient in many cases.…”

Section: Introductionmentioning

confidence: 99%

Biosensing of DNA oxidative damage: a model of using glucose meter for non-glucose biomarker detection

Zhu¹,

Sarwar²,

Yue³

et al. 2017

IJN

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Non-glucose biomarker-DNA oxidative damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) has been successfully detected using a smartphone-enabled glucose meter. Through a series of immune reactions and enzymatic reactions on a solid lateral flow platform, 8-OHdG concentration has been converted to a relative amount of glucose, and therefore can be detected by conventional glucose meter directly. The device was able to detect 8-OHdG concentrations in phosphate buffer saline as low as 1.73 ng mL −1 with a dynamic range of 1–200 ng mL −1 . Considering the inherent advantages of the personal glucose meter, the demonstration of this device, therefore, should provide new opportunities for the monitoring of a wide range of biomarkers and various target analytes in connection with different molecular recognition events.

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“…Owing to its capability of rapid, label-free, cost-effective detection of molecular interaction with kinetics information [1][2][3], surface plasmon resonance (SPR)-based optical sensors have been demonstrated in the past decade to be a powerful tool not only for the measurement of molecular binding kinetics and binding affinity, but also for quantitative analysis of genetic and proteomic biomarkers. The detection of analytes by SPR relies on the successful immobilization of biomolecular recognition probes, such as antibody, aptamer and molecular imprinted polymer at the metal-media interface [4][5][6].…”

mentioning

confidence: 99%

Sensing system for mimicking cancer cell–drug interaction

Zhao

2015

Science Bulletin

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Paper based point-of-care testing disc for multiplex whole cell bacteria analysis

Cited by 192 publications

References 31 publications

Point-of-Care Diagnostics

Point-of-Care Diagnostics

Biosensing of DNA oxidative damage: a model of using glucose meter for non-glucose biomarker detection

Sensing system for mimicking cancer cell–drug interaction

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