Papain-Induced Asthma: A Man With Dyspnea From Dawn Till Dust

Goeminne, Pieter; Adams, Elizabeth E.; Deschepper, Koen; Valcke, Y.; Nemery, Benoît

doi:10.2143/acb.3214

Cited by 6 publications

(4 citation statements)

References 7 publications

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“…Asthma could be induced by inhalation of various allergens (such as mold spores, pollen, mold, and dust mites) [1], air pollutants (such as smoke) [4], and protease allergen such as papain. The latter has been reported to cause occupational asthma in humans [5,6] and asthmalike symptoms in mice [7,8]. Asthma is one of the complex multifactorial diseases, thus several animal models were used to study their progression and pathogenesis following Int.…”

Section: Introductionmentioning

confidence: 99%

Possible Crosstalk of the Immune Cells within the Lung and Mediastinal Fat-Associated Lymphoid Clusters in the Acute Inflammatory Lung Asthma-Like Mouse Model

Elewa

Elwakil

Ichii

et al. 2021

IJMS

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Recently, we clarified the function of mediastinal fat-associated lymphoid clusters (MFALCs) in the progression of several respiratory diseases. However, their role has not yet been identified in the lung asthmatic condition. Hence, we compared the immune cells in lung and MFALCs of C57BL/6N mice on days 3 and 7 following intranasal instillation of either papain (papain group “PG”) or phosphate buffer saline (PBS) (vehicle group “VG”). The PG showed significantly prominent MFALCs, numerous goblet cells (GCs), and higher index ratios of different immune cells (macrophages, natural helper cells (NHC), B- and T-lymphocytes) within the MFALCs and lung than in the VG on both days 3 and 7. Interestingly, a tendency of decreased size of MFALCs and a significant reduction in the number of GCs and immune cells were observed within the MFALCs and lung in the PG on day 7 than on day 3. Furthermore, the quantitative parameters of these immune cells in MFALCs were significantly and positively correlated with the size of MFALCs and immune cells in the lung. This suggested that the possible crosstalk between immune cells within MFALCs and the lung could play a critical role in the progression and recovery of the acute inflammatory lung asthma.

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Section: Introductionmentioning

confidence: 99%

Possible Crosstalk of the Immune Cells within the Lung and Mediastinal Fat-Associated Lymphoid Clusters in the Acute Inflammatory Lung Asthma-Like Mouse Model

Elewa

Elwakil

Ichii

et al. 2021

IJMS

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“… 3 It has well documented that papain can induce reactions through different routes: respiratory, 2 4 5 skin/conjunctival, 6 7 8 or oral. 9 Papain allergy can occur in occupational and non-occupational settings, and most of the affected subjects work in a factory, 4 5 a biochemical laboratory, 2 or a beauty salon. 6 8 Food processors may affect IgE-mediated allergic occupational diseases through halation of airborne particles, skin contact, or ingestion.…”

Section: Introductionmentioning

confidence: 99%

Papain Induced Occupational Asthma with Kiwi and Fig Allergy

Jiang

Yin

Wen

2016

Allergy Asthma Immunol Res

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Papain is a proteolytic enzyme which is widely used in food industry, pharmaceuticals, and cosmetics. Occupational and non-occupational papain allergies have previously been documented; however, there are limited publications about papain allergy with its relative fruit allergy. Here, we present a case of occupational, IgE-mediated papain allergy with kiwi fruit and fig fruit allergy. A 53-year-old man suffered from rhinitis for several years, with the onset of his symptoms coinciding with the time he started to work at a sausage processing plant where papain is often used as a meat tenderizer. He began to experience symptoms of chest tightness, shortness of breath and wheezing shortly after starting work 5 years ago. Furthermore, he experienced several episodes of oral itching, and tongue and oropharyngeal angioedema after injestion of kiwi fruit and fig fruit. The patient had a lifelong history of allergic conjunctivitis, allergic rhinitis, and childhood asthma. Specific IgE was positive to kiwi fruit, papain and chymopapain (2.95 kUA/L, >100 kUA/L, and 95.0 kUA/L, respectively). Similar bands at 10-15 kDa in blotting with papain and kiwi fruit extracts were found. This patient showed a potential association between papain allergy and sensitization to kiwi fruit. We also reviewed 13 patients with papain allergy published in the literature, with 85% (11/13) of the patients sensitized through the respiratory tract, and 40% (4/11) having atopy. Further studies should focus on the determination of cross-reactive allergens between papain and its fruit relatives, and the prevalence of food allergy in patients with papain allergy should be investigated in a relatively large cohort.

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“…Cellular analysis of the patient's sputum, nasal lavage and tear fluid before and after the specific inhalation and nasal challenge test with papain Tabela 1. Ocena cytologiczna plwociny, popłuczyn nosowych i łez pobranych od pacjenta przed swoistą prowokacją wziewną i donosową z papainą oraz po prowokacji Papain-induced rhinoconjunctivitis and asthma Nr 1 111 to other reports [1][2][3]5], the immunoglobulin E-mediated (IgE) sensitization to papain was confirmed with a positive SPT result with a papain solution. In our case, the SICT and SNCT with papain induced allergic responses from the respiratory system and conjunctiva.…”

Section: Discussionunclassified

Papain-induced occupational rhinoconjunctivitis and asthma – A case report

Tymoszuk

Wiszniewska

Walusiak‐Skorupa

2016

Med Pr

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This report presents a case of occupational asthma, rhinitis and conjunctivitis to papain in a 50-year-old herbs and spices packer, with documented increased eosinophilia in induced sputum and in the nasal lavage fluids after a specific inhalation challenge test (SICT) and specific nasal challenge test (SNCT) with this enzyme. Immunoglobulin E-mediated (IgE) sensitization to papain was confirmed by positive results of a skin prick test with specific solution. Specific inhalation and nasal challenge tests demonstrated a direct and significant link between the exposure to this protease and the allergic response from the respiratory system. Additionally, the SNCT induced a severe reaction of the conjunctivae and a significant increase in the count of eosinophils in tears, despite the lack of direct contact of the allergen with the conjunctiva. Med Pr 2016;67(1):109-112Key words: asthma, occupational allergy, enzyme, rhinitis, papain, conjunctivitis Streszczenie W artykule opisano przypadek zawodowej astmy oskrzelowej, alergicznego nieżytu nosa i zapalenia spojówek wywołanych papainą u 50-letniej pakowaczki ziół i przypraw. W badaniu cytologicznym udokumentowano wzrost odsetka eozynofilów w indukowanej plwocinie i popłuczynach nosowych po swoistej próbie prowokacyjnej wziewnej i donosowej z tym enzymem. Zależną od immunoglobuliny E (IgE) nadwrażliwość pacjentki na papainę potwierdzono dodatnimi wynikami punktowych testów skór-nych z roztworem tej proteazy. Wyżej wymienione próby prowokacyjne wykazały istotny związek między ekspozycją na papainę a reakcją alergiczną ze strony układu oddechowego. Ponadto swoista próba prowokacyjna donosowa wywołała wzmożoną reakcję ze strony spojówek i istotny wzrost odsetka eozynofilów we łzach mimo braku bezpośredniego kontaktu alergenu ze spojów-kami. Med. Pr. 2016;67(1):109-112 Słowa kluczowe: astma, alergia zawodowa, enzym, alergiczny nieżyt nosa, papaina, alergiczne zapalenie spojówek Corresponding author / Autorka do korespondencji: Diana Tymoszuk,

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Papain-Induced Asthma: A Man With Dyspnea From Dawn Till Dust

Cited by 6 publications

References 7 publications

Possible Crosstalk of the Immune Cells within the Lung and Mediastinal Fat-Associated Lymphoid Clusters in the Acute Inflammatory Lung Asthma-Like Mouse Model

Possible Crosstalk of the Immune Cells within the Lung and Mediastinal Fat-Associated Lymphoid Clusters in the Acute Inflammatory Lung Asthma-Like Mouse Model

Papain Induced Occupational Asthma with Kiwi and Fig Allergy

Papain-induced occupational rhinoconjunctivitis and asthma – A case report

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