Papain-induced occupational rhinoconjunctivitis and asthma – A case report

Tymoszuk, Diana; Wiszniewska, Marta; Walusiak‐Skorupa, Jolanta

doi:10.13075/mp.5893.00317

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…Data about the gastrointestinal resistance of the pollen and mite PLCPs are not available. In reality, in addition to food proteins, every protein known as inhaled allergen can also be ingested ( Figure 2 ) and vice versa—some food allergenic proteins ( Figure 1 ) can be inhaled [ 35 , 59 , 60 ]. For instance, it is possible for pollen allergens to be ingested in foods such as honey or in periods of pollination [ 61 , 62 , 63 , 64 , 65 ].…”

Section: Resistance To Gastrointestinal Digestionmentioning

confidence: 99%

“…Outside those geographical areas sensitisation to papaya does not usually occur from eating papaya fruit. In fact, rhinitis and asthma are reported to affect only workers of industries where papaya is handled [ 35 , 126 , 127 , 128 ]. A single case was reported many years ago [ 129 ] of a patient experiencing severe systemic allergic reaction after the ingestion of meat tenderiser.…”

Section: Sources Of Plcps Known For Allergenicity And/or Ige Bindingmentioning

confidence: 99%

“…Cari p papain [9] Papain/EC 3.4. 22.2 Food 24 [33] Food, inhalation, skin contact [35,36] Unstable [37] need encapsulation Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1 ′ .…”

Section: Carica Papaya (Papaya)mentioning

confidence: 99%

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Plant and Arthropod IgE-Binding Papain-like Cysteine Proteases: Multiple Contributions to Allergenicity

Giangrieco,

Ciardiello,

Tamburrini

et al. 2024

Foods

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Papain-like cysteine proteases are widespread and can be detected in all domains of life. They share structural and enzymatic properties with the group’s namesake member, papain. They show a broad range of protein substrates and are involved in several biological processes. These proteases are widely exploited for food, pharmaceutical, chemical and cosmetic biotechnological applications. However, some of them are known to cause allergic reactions. In this context, the objective of this review is to report an overview of some general properties of papain-like cysteine proteases and to highlight their contributions to allergy reactions observed in humans. For instance, the literature shows that their proteolytic activity can cause an increase in tissue permeability, which favours the crossing of allergens through the skin, intestinal and respiratory barriers. The observation that allergy to PLCPs is mostly detected for inhaled proteins is in line with the reports describing mite homologs, such as Der p 1 and Der f 1, as major allergens showing a frequent correlation between sensitisation and clinical allergic reactions. In contrast, the plant food homologs are often digested in the gastrointestinal tract. Therefore, they only rarely can cause allergic reactions in humans. Accordingly, they are reported mainly as a cause of occupational diseases.

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Section: Resistance To Gastrointestinal Digestionmentioning

confidence: 99%

Section: Sources Of Plcps Known For Allergenicity And/or Ige Bindingmentioning

confidence: 99%

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Plant and Arthropod IgE-Binding Papain-like Cysteine Proteases: Multiple Contributions to Allergenicity

Giangrieco,

Ciardiello,

Tamburrini

et al. 2024

Foods

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“…Comparison between control populations showed that Foxa2 is ~6-fold more highly expressed in lung epithelial cells than in lung T-cells (Figure S3A). To induce AAD, we used papain as allergen, which induces allergic airway inflammation by initiating a Th2 immune response and is linked to occupational and non-occupational asthma and allergy in humans (29,35,(39)(40)(41)(42)(43)(44)(45). We administered intranasal papain in PBS to Foxa2cKO (Foxa2f/fCD4Cre+) and control (Foxa2f/ fCD4Cre neg ) mice on day 0 and day 7 and sacrificed mice on day 10, treating with PBS alone at the same time points as negative control (Figure S1A).…”

Section: Conditional Deletion Of Foxa2 From T-cells Increases Inflamm...mentioning

confidence: 99%

The Pioneer Transcription Factor Foxa2 Modulates T Helper Differentiation to Reduce Mouse Allergic Airway Disease

et al. 2022

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Foxa2, a member of the Forkhead box (Fox) family of transcription factors, plays an important role in the regulation of lung function and lung tissue homeostasis. FOXA2 expression is reduced in the lung and airways epithelium of asthmatic patients and in mice absence of Foxa2 from the lung epithelium contributes to airway inflammation and goblet cell hyperplasia. Here we demonstrate a novel role for Foxa2 in the regulation of T helper differentiation and investigate its impact on lung inflammation. Conditional deletion of Foxa2 from T-cells led to increased Th2 cytokine secretion and differentiation, but decreased Th1 differentiation and IFN-γ expression in vitro. Induction of mouse allergic airway inflammation resulted in more severe disease in the conditional Foxa2 knockout than in control mice, with increased cellular infiltration to the lung, characterized by the recruitment of eosinophils and basophils, increased mucus production and increased production of Th2 cytokines and serum IgE. Thus, these experiments suggest that Foxa2 expression in T-cells is required to protect against the Th2 inflammatory response in allergic airway inflammation and that Foxa2 is important in T-cells to maintain the balance of effector cell differentiation and function in the lung.

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“…PLCPs can cause occupational allergic reactions due to exposure to airborne particles, as reported, for instance, for papain [11,31] or bromelain [32]. The same allergens can cause nonoccupational reactions due to the ingestion of foods containing the allergenic protein [33].…”

Section: Introductionmentioning

confidence: 96%

Comparative Analysis of the Immune Response and the Clinical Allergic Reaction to Papain-like Cysteine Proteases from Fig, Kiwifruit, Papaya, Pineapple and Mites in an Italian Population

Giangrieco

Ciardiello

Tamburrini

et al. 2023

Foods

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Several plant papain-like cysteine proteases are exploited by the food, cosmetic, pharmaceutical and textile industries. However, some of these enzymes can cause allergic reactions. In this context, we investigated the frequency of sensitization and allergic reactions to some fruit and/or latex cysteine proteases, which are used as additives by the food industry to improve and modify the quality of their products. The FABER test was used to analyse the patients‘ sensitization towards five plants and, for comparison, two homologous mite cysteine proteases. In an Italian population of 341 allergic patients, 133 (39%) had IgE specific for at least one of the seven cysteine proteases under investigation. Most of the patients were IgE positive for Der p 1 and/or Der f 1 (96.38%) reported a clinical history suggestive of respiratory allergy to mites, whereas none of the subjects sensitized to the homologs from papaya, pineapple and fig reported allergy symptoms following ingestion of these foods. Only one patient referred symptoms from ingesting kiwifruit. Therefore, the obtained results showed that sensitization to the fruit enzymes was only rarely concomitant with allergic reactions. These observations, together with the literature reports, suggest that the allergy to plant papain-like cysteine proteases might mainly be an occupational disease.

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Papain-induced occupational rhinoconjunctivitis and asthma – A case report

Cited by 8 publications

References 10 publications

Plant and Arthropod IgE-Binding Papain-like Cysteine Proteases: Multiple Contributions to Allergenicity

Plant and Arthropod IgE-Binding Papain-like Cysteine Proteases: Multiple Contributions to Allergenicity

The Pioneer Transcription Factor Foxa2 Modulates T Helper Differentiation to Reduce Mouse Allergic Airway Disease

Comparative Analysis of the Immune Response and the Clinical Allergic Reaction to Papain-like Cysteine Proteases from Fig, Kiwifruit, Papaya, Pineapple and Mites in an Italian Population

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