Pancreatic Cystadenoma

Hodgkinson, Darryl; ReMine, William H.; Weiland, Louis H.

doi:10.1001/archsurg.1978.01370160170030

Cited by 152 publications

(4 citation statements)

References 12 publications

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“…They are usually asymptomatic or give rise to nonspecific symptoms [3,7,9,12]. Few cases of pancreatic cystadenomas with hypercellular, mesenchymal underlying stroma have been reported in the literature [3,7,12,[16][17][18][19], and they are more commonly encountered in the liver and the bile ducts [20]. These lesions occur almost exclusively in women [1,5,11,12,15,17].…”

Section: Introductionmentioning

confidence: 99%

A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors

et al. 1998

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A 43-year-old man presented with abdominal discomfort caused by relapsing pancreatitis. Radiological examination revealed a multilocular cystic mass in the tail of the pancreas, which was resected. Gross examination showed a multilocular cystic lesion measuring 2.5 cm in diameter and containing clear fluid. Microscopically, a mucinous cystadenoma with mesenchymal stroma was diagnosed. The lesion showed two different components: a cyst lined by a columnar, mucin-secreting epithelium and a moderate cellular stroma composed of spindle cells. The stromal element appeared similar to primitive mesenchyme. Immunohistochemical staining confirmed this origin through vimentin expression and showed moderate to strong nuclear staining with oestrogen and progesterone receptor antibodies. Cystadenomas are rare tumours of the pancreas, but mesenchymal stroma is uncommon in such tumours; it is more frequently described in the liver and the bile ducts, and primarily in women.

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Section: Introductionmentioning

confidence: 99%

A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors

et al. 1998

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“…Serous cystic neoplasms (SCNs) are relatively uncommon, accounting for 1–2% of all pancreatic neoplasms, and were first reported by Compagno 1 and Hodgkinson 2 in 1978. Approximately 75% of SCNs occur in females ranging between 26 and 89 years of age (mean age, 62.1 years).…”

Section: Discussionmentioning

confidence: 99%

Incidentally detected microcystic serous cystadenoma of the pancreas with splenic invasion: a case report and literature review

et al. 2020

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Serous cystic neoplasms are relatively uncommon and rarely possess malignant potential. We report a rare case of pancreatic serous cystadenoma with splenic invasion in a female in her 60s. Dynamic contrast-enhanced CT revealed a 3 cm mass in the tail of the pancreas. The lesion showed marked enhancement in the arterial phase on dynamic CT, which extended into the spleen. No cystic components were detected in the pancreatic mass on either magnetic resonance cholangiopancreatography or T2 weighted imaging. No metastasis or lymph node swelling was detected. Based on the hypervascularity of the tumour, the pre-operative diagnosis was pancreatic neuroendocrine tumour with splenic invasion. The patient underwent laparoscopic distal pancreatectomy with splenectomy. The pathological diagnosis was microcystic serous cystadenoma with locally aggressive features (infiltration into spleen, lymph nodes, and splenic vein). A few cases of pancreatic serous cystadenomas with splenic invasion have been reported; all were symptomatic, with diameters greater than approximately 9 cm. This is the first known case of incidentally detected serous cystadenoma with splenic invasion, reported with detailed imaging findings of dynamic CT and MRI.

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“… 17 In 1978, SCs of pancreas were separated from pancreatic mucinous cystic neoplasms. 18 , 19 Based on the IHC and ultrastructural findings, SCs are believed to be derived from intercalated duct cell or centroacinar cell lineage. 20 , 21…”

Section: Discussionmentioning

confidence: 99%

Serous cystadenoma of pancreas: A clinicopathologic experience of 23 cases from a major tertiary care center

et al. 2018

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Background:Serous cystadenomas of pancreas are rare benign epithelial neoplasms, which predominantly occur in the pancreatic body and tail of elderly females. Majority of these tumors have microcystic appearance. Macrocystic and solid variants have also been described. A number of more aggressive cystic pancreatic lesions are included in the differential diagnosis. Distinction from such lesions is important for optimal management.Objective:Our aim was to study the clinical and histological features of serous cystadenomas which would be helpful in making their correct diagnosis and understanding their behavior.Methods:We reviewed 23 cases of serous cystadenomas diagnosed in our institution between January 2001 and June 2018.Results:Mean age at presentation was 53.43 years. Female to male ratio was 4.75:1. Over half (56.5%) of the cases were diagnosed incidentally. Abdominal pain was the most common symptom. Body and tail (either alone or in combination) were the most common locations. Tumor size ranged from 2 to 16 cm. Central scar was seen in 43.4% cases. Two cases were unilocular (macrocystic). Microscopically, all cases showed simple cuboidal to flattened epithelium with round, uniform nuclei, and glycogen-rich clear cytoplasm. Focal micropapillae formation was seen in eight cases (34.7%). Surgical resection was performed in 82.6% cases. Recurrence occurred in only one single case.Conclusion:Pancreatic serous cystadenomas are benign neoplasms with excellent prognosis. The tumors showed typical morphological features in all cases. Surgical resection was performed in the majority of cases in our study owing to lack of optimal and complete radiological workup pre-operatively and the concern for not missing and adequately treating pancreatic mucinous cystic neoplasms.

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Pancreatic Cystadenoma

Cited by 152 publications

References 12 publications

A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors

A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors

Incidentally detected microcystic serous cystadenoma of the pancreas with splenic invasion: a case report and literature review

Serous cystadenoma of pancreas: A clinicopathologic experience of 23 cases from a major tertiary care center

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