A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors

Wouters, Karel; Ectors, Nadine; Steenbergen, Werner Van; Aerts, Raymond; Driessen, Ann; Hoe, Lieven Van; Geboes, Karel

doi:10.1007/s004280050154

Cited by 42 publications

(36 citation statements)

References 10 publications

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“…Immunohistochemical staining for estrogen and progesterone receptor was not routinely performed in our study if OS was clearly evident from microscopical examination. The description of a male patient with cystadenoma of the pancreas containing stromata that expressed estrogen and progesterone receptors is remarkable [14]. To our knowledge, the presence of mucinous cystadenoma with OS in the spleen has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Cystadenomas with Ovarian Stroma in Liver and Pancreas: An Evolving Concept

Erdogan¹,

Lamers²,

Offerhaus

et al. 2006

Dig Surg

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Background: Mucinous cystic neoplasms with ovarian stroma (OS) are rare cystic neoplasms in the liver and pancreas. The aim was to investigate whether OS in mucinous cystadenomas can originate from gonadal epithelium during early embryonic development. Patients and Methods: Pathology specimens of patients with mucinous cystadenomas were reviewed for OS. In human embryos, morphology of the peritoneal epithelium and the position of the gonads in relation to the embryonic liver, pancreas and spleen were examined. Results: From 1994 to 2004, 22 female patients presented with mucinous neoplasms of the liver or pancreas, including 19 cystadenomas and 3 cystadenocarcinomas. Mean age of the patients with cystadenoma in the liver was 44.8 years and with cystademona in the pancreas 41.2 years. OS was present in all mucinous cystadenomas, including the cystadenocarcinomas. In human embryos, preceding their ‘descent’, the gonads are situated directly under the diaphragm, dorsal to the liver, the tail of the pancreas and the spleen, but separated from these organs by the peritoneal cavity. In contrast to the peritoneal epithelium elsewhere, the cells covering the gonads show an activated morphology. Conclusion: OS in mucinous cystadenomas of the liver and pancreas suggest a common origin in epithelial cells that cover the embryonic gonads in early fetal life.

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Section: Discussionmentioning

confidence: 99%

Cystadenomas with Ovarian Stroma in Liver and Pancreas: An Evolving Concept

Erdogan¹,

Lamers²,

Offerhaus

et al. 2006

Dig Surg

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“…In a study of 56 MCN defi ned strictly by presence of ovarian stroma, 9 patients (16%) were 1 60 years of age [28] . Also, there are male patients with mucinous cystadenoma with ovarian-type stroma [28,31] .…”

Section: C Should Ovarian-type Stroma Be a Histological Requirementmentioning

confidence: 99%

International Consensus Guidelines for Management of Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms of the Pancreas

et al. 2006

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“…The higher frequencies that have been reported in some previous studies are probably due to the fact that IPMNs and MCNs were not clearly distinguished from each other or were still interpreted as a single entity. The clear differentiation of MCNs from IPMNs also revealed that MCNs are extremely rare in men [31,37]. The mean age at diagnosis is usually below 50 years (table 3), though patients with invasive carcinoma are often older than 50 years.…”

Section: Mucinous Cystic Neoplasmmentioning

confidence: 99%