Pancreatic B-Cell Defects in Gestational Diabetes: Implications for the Pathogenesis and Prevention of Type 2 Diabetes

Prediction of developing metabolic syndrome after gestational diabetes mellitus

“…This relationship was independent of patient's current age, BMI, waist circumference, and postpartum duration. It has been demonstrated that women with GDM had defects in both insulin sensitivity and insulin secretion (25). In one study, women with GDM were found to be more insulin resistant, and also had lower insulin increment at the index pregnancy compared non-GDM women (26).…”

Gestational Diabetes and the Metabolic Syndrome

“…Indeed, the relation between GDM and T2DM is well described, and the two conditions share a similar pathophysiology, characterized by insulin resistance of peripheral tissues and insufficient secretion of insulin by the pancreatic beta cells to compensate for this resistance (Buchanan, 2001;Buchanan & Xiang, 2005;Retnakaran et al, 2010a). Pregnancy itself has been described as a "stress test" for T2DM and CVD (Reece et al, 2009).…”

Current controversies in the mechanisms and treatment of gestational diabetes

“…The first-phase insulin response to intravenous glucose is also disturbed in GDM. Although the secondphase insulin response is not significantly different from normal in GDM, the insulinogenic index (the insulin response per unit of glycemic stimulus), however, is only 40% compared with the healthy 90% value [1,[14][15][16].…”

“…The increased proinsulin-to-insulin molar ratio was suggested as a characteristic feature of GDM, and a predictor of T2DM later in life. This parameter is believed to reflect β-cell secretory dysfunction [16].…”